Çocuklarda Helicobacter pylori Enfeksiyonu ile Çölyak Hastalığı Arasındaki İlişki

Abstract

Amaç Çölyak hastalığı, prevalansı giderek artan kronik bir otoimmün bozukluktur. Helicobacter pylori, mide ve duodenumda inflamasyona yol açan bir enfeksiyon olup, gelişmekte olan ülkelerde prevalansı giderek azalmaktadır. Helicobacter pylori’nin çölyak hastalığının artan prevalansındaki rolünü inceleyen çalışmaların çoğu erişkin popülasyonlara odaklanmıştır. Bu çalışmada, söz konusu ilişkiyi çocuklarda inceleyerek literatüre katkıda bulunmayı amaçladık. Gereç ve Yöntem Çalışma, tek merkezli ve retrospektif bir tasarımla yürütülmüştür. Ocak 2010 ile Aralık 2024 tarihleri arasında çeşitli endikasyonlarla üst gastrointestinal endoskopi ve biyopsi uygulanan, 1–18 yaş aralığındaki hastalar değerlendirilmiştir. Olgular, yaş gruplarına ve çalışma yıllarına göre kategorize edilerek analiz edilmiştir. Bulgular Çalışma süresince toplam 2.659 tanısal endoskopi gerçekleştirilmiştir. Dahil edilme kriterlerini karşılayan toplam 1.910 pediatrik hasta çalışmaya dahil edilmiştir (ortalama yaş: 11,99 ± 4,62 yıl; %62,3’ü kız). Nihai tanılara göre 151 hasta (%7,9) çölyak hastalığı grubuna, 1.759 hasta (%92,1) kontrol grubuna dahil edilmiştir. Helicobacter pylori prevalansı çölyak grubunda daha düşük saptanmış; ancak bu fark istatistiksel olarak anlamlı bulunmamıştır. Çölyak hastalarında Helicobacter pylori enfeksiyon oranları, Marsh evresi arttıkça hafif bir artış göstermiş; ancak bu bulgu da istatistiksel olarak anlamlı değildir (p > 0,05). Sonuç Çalışmamız, çölyak hastalığı olan çocuklarda Helicobacter pylori enfeksiyonunun daha düşük sıklıkta görüldüğünü, ancak bu farkın istatistiksel olarak anlamlı olmadığını göstermiştir.

Keywords

• Çölyak hastalığı
• Çocuklar
• Helicobakter pylori
• Endoskopi
• Marsh sınıflaması

The Relationship Between Helicobacter pylori Infection And Celiac Disease In Children

Abstract

Background/Aims Celiac disease is a chronic autoimmune disorder with an increasing prevalence. Helicobacter pylori is an infection that causes inflammation in the stomach and duodenum, and its prevalence has been gradually declining in developing countries. Most studies examining the role of Helicobacter pylori in the increasing prevalence of celiac disease have focused on adult populations. In this study, we aimed to contribute to the literature by examining this relationship in children. Materials and Methods The study was designed as a single-center, retrospective study. Patients aged 1 to 18 years who underwent upper gastrointestinal endoscopy with biopsy for various indications between January 2010 and December 2024 were evaluated. Cases were analyzed by categorizing them based on age groups and study years. Results During the study period, a total of 2,659 diagnostic endoscopies were performed. A total of 1,910 pediatric patients who met the inclusion criteria were included in the study (mean age: 11.99 ± 4.62 years, 62.3% female). Based on final diagnoses, 151 patients (7.9%) were classified in the celiac disease group, while 1,759 patients (92.1%) comprised the control group. The prevalence of Helicobacter pylori was lower in the celiac group; however, this difference was not statistically significant. Among celiac patients, Helicobacter pylori infection rates showed a slight increase with higher Marsh stages, but this finding was not statistically significant (p>.05). Conclusion Our study demonstrated that Helicobacter pylori infection was less frequent in children with celiac disease; however, the difference was not statistically significant.

Keywords

• Celiac Disease
• Children
• Helicobacter pylori
• endoscopy
• Marsh classification

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