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Kliniğimizde Yatarak İzlenen Kateter İlişkili Kan Dolaşımı İnfeksiyonu Tanılı Hastaların Değerlendirilmesi

Year 2026, Volume: 17 Issue: 1 , 104 - 115 , 20.04.2026
https://doi.org/10.22312/sdusbed.1717595
https://izlik.org/JA68ZZ63MC

Abstract

Giriş: Santral venöz kateterizasyonun en sık görülen, ölümcül ve maliyetli komplikasyonlarından olan kateter ilişkili kan dolaşımı infeksiyonu aynı zamanda nozokomiyal bakteremilerin en sık nedenidir. Kateter ilişkili kan dolaşımı enfeksiyonları (KİKDE), hemodiyaliz hastalarında kardiyovasküler hastalıktan sonra ikinci önde gelen ölüm nedenidir. Bu infeksiyonlar infektif endokardit, spondilodiskit, paravertebral apse gibi birçok metastatik komplikasyona neden olabilir. Çalışmamızda KİKDE’nin ve metastatik komplikasyonların değerlendirilmesi amaçlanmıştır. Materyal-Metod: Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji kliniğinde tedavi gören KİKDE olan hastalardaki infeksiyon epizodları retrospektif olarak değerlendirildi. Hastaların demografik verileri, klinik semptomları, eşlik eden hastalıkları, kateter özellikleri, fizik muayene bulguları, izole edilen mikroorganizma ve antibiyotik duyarlılığı, inflamasyon parametreleri, metastatik komplikasyonları kaydedildi. Bulgular: Belirlenen zaman aralığında toplam 51 hastada 63 KİKDE epizodu saptandı. Hastaların %54,9’u erkek olup yaş ortalaması 60,7±16,2 yıl olarak bulundu. Hastaların %82,4’ü diyaliz kateteri ile hemodiyalize alınan olgulardı. Toplam 63 epizodun %85,7’si hemodiyaliz alan olgularda saptandı. Elli bir hastanın %37,3’ünde toplam 20 komplikasyon saptandı. İlk üç sırada görülen komplikasyonlar diskit, infektif endokardit ve psoas apsesi olarak bulundu. Bu komplikasyonlarından en sık sorumlu olan etken metisilin duyarlı Staphylococcus aureus (MSSA) idi. Sonuç: Hemodiyaliz alan olgularda KİKDE’nin yanısıra infeksiyonla ilişkili komplikasyonlar da daha sıktır. Kateter bakımı ve kişisel hijyen konularında olguların eğitimi, hastanelerde KİKDE’yi önleme demetlerinin uygulanması ve hemodiyaliz olgularını mümkün olan durumlarda fistül seçeneğine yönlendirme bu komplikasyonların görülme oranını azaltabilir.

References

  • 1. Blanchard AC, Fortin E, Rocher I, Moore DL, Frenette C, Tremblay C, et al. Central line-associated bloodstream infection in neonatal intensive care units. Infect Control Hosp Epidemiol. 2013;34(11):1167–1173. doi:10.1086/673464
  • 2. Allon M. Dialysis catheter-related bacteremia: treatment and prophylaxis. American Journal of Kidney Diseases. 2004;44(5):779-791.doi.org/10.1053/j.ajkd.2004.07.005
  • 3. Lewis SS, Sexton DJ. Metastatic Complications of Bloodstream Infections in Hemodialysis Patients. Seminars in Dialysis. 2013;26(1): 47-53. doi:10.1111/sdi.12031
  • 4. Jackson SS, Leekha S, Magder LS, Pineles L, Anderson DJ, Trick WE, et al. The effect of adding comorbidities to current centers for disease control and prevention central-line-associated bloodstream infection risk-adjustment methodology. Infect Control Hosp Epidemiol.2017;38(9):1019–1024. doi:10.1017/ice.2017.129
  • 5. Pepin CS, Thom KA, Sorkin JD, Leekha S, Masnick M, Preas MA, et al. Risk factors for central-line-associated bloodstream infections: a focus on comorbid conditions. Infect Control Hosp Epidemiol. 2015;36(4):479–481. doi:10.1017/ice.2014.81
  • 6. Alshahrani KM, Alhuwaishel AZ, Alangari NM, Asiri MA, Al-Shahrani NA, Alasmari AA, et al. Clinical Impacts and Risk Factors for Central Line-Associated Bloodstream Infection: A Systematic Review. Cureus. 2023;15(6):e40954. doi:10.7759/cureus.40954
  • 7. See I, Freifeld AG, Magill SS. Causative Organisms and Associated Antimicrobial Resistance in Healthcare-Associated, Central Line-Associated Bloodstream Infections From Oncology Settings, 2009-2012. Clinical Infectious Diseases.2016;62(10):1203–1209. doi:10.1093/cid/ciw113
  • 8. Aydın M, Kaşıkçıoğlu C, Nargiz Koşucu S, Timurkaynak F, Arslan H. Kan Dolaşımı İnfeksionu Etkenleri ve Antibiyotik Direnç Oranları Klimik Journal/Klimik Dergisi.2016;29(2): doi: 10.5152/kd.2016.19
  • 9. Shingarev R, Barker-Finkel J, Allon M. Natural history of tunneled dialysis catheters placed for hemodialysis initiation. J Vasc Interv Radiol. 2013;24(9):1289-1294. doi:10.1016/j.jvir.2013.05.034
  • 10. Farrington CA, Allon M. Management of the Hemodialysis Patient with Catheter-Related Bloodstream Infection. Clin J Am Soc Nephrol. 2019;14(4):611-613. doi:10.2215/CJN.13171118
  • 11. Novosad SA, Fike L, Dudeck MA, Allen-Bridson K, Edwards JR, Edens C, et al. Pathogens causing central-line-associated bloodstream infections in acute-care hospitals-United States, 2011-2017. Infection control and hospital epidemiology.2020;41(3):313–319. doi:10.1017/ice.2019.303
  • 12. Engemann JJ, Friedman JY, Reed SD, Griffiths RI, Szczech LA, Kaye KS, et al. Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis. Infection control and hospital epidemiology. 2005;26(6):534–539. doi:10.1086/502580
  • 13. Farrington CA, Allon M. Complications of Hemodialysis Catheter Bloodstream Infections: Impact of Infecting Organism. American journal of nephrology.2019;50(2):126–132. doi:10.1159/000501357
  • 14. European Committee on Antimicrobial Susceptibility Testing (2023)[Internet]. Breakpoint tables for interpretation of MICs and zone diameters. Version 13.0.; 2023 Oct 2 [cited 2025 Apr 17]. Available from: http://www.eucast.org
  • 15. Guo H, Zhang L, He H, Wang L. Risk factors for catheter-associated bloodstream infection in hemodialysis patients: A meta-analysis. PLoS One.2024;19(3):e0299715. doi:10.1371/journal.pone.0299715
  • 16. Al-Solaiman Y, Estrada E, Allon M. The spectrum of infections in catheter-dependent hemodialysis patients. Clinical journal of the American Society of Nephrology:CJASN.2011;6(9):2247–2252. doi:10.2215/CJN.03900411
  • 17. Arslan M, Kahraman E, Menekşe E. Tunneled Catheter‐Related Bloodstream Infections in Chronic Hemodialysis Patients: Frequency, Risk Factors, and Outcomes—A 10‐Year Analysis. Apmis.2025;133(3): e70016. doi:10.1111/apm.70016
  • 18. İnce N, Yekenkurul D, Çalışkan E, Gürbüz AR, Yener S. Investigation of the Factors Associated with Mortality in Catheter-Related Bloodstream Infections: Five-Year Observation. Duzce Medical Journal.2020;22(3):149-153. doi:10.18678/dtfd.746887
  • 19. Agrawal V, Valson AT, Mohapatra A, David VG, Alexander S, Jacob S, et al. Fast and furious: a retrospective study of catheter-associated bloodstream infections with internal jugular nontunneled hemodialysis catheters at a tropical center, Clinical Kidney Journal.2019;12(5):737–744. doi:10.1093/ckj/sfy138
  • 20. Özkan P, Güney İ, Karakose S, Topal M, Erkuş E, Tarakcı A. The evaluation of catheter infections in kidney disease patients. J Contemp Med.2021;11(1):69-74. doi:10.16899/jcm.734057
  • 21. Timsit JF, Rupp M, Bouza, E, Chopra V, Kärpänen T, Laupland K, et al. A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill. Intensive Care Med.2018;44(6): 742–759. doi:10.1007/s00134-018-5212-y
  • 22. Baang JH, Inagaki K, Nagel J, Ramani K, Stillwell TL, Mack M, et al. Inpatient Diagnosis and Treatment of Catheter-Related Bloodstream Infection [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK589895/
  • 23. Chaves F, Garnacho-Montero J, Del Pozo JL, Bouza E, Capdevila, JA, de Cueto M, et al. Executive summary: Diagnosis and Treatment of Catheter-Related Bloodstream Infection: Clinical Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) and the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC). Enfermedades infecciosas y microbiologia clinica (English ed.).2018;36(2):112–119. doi:10.1016/j.eimc.2017.10.019
  • 24. Krishnasami Z, Carlton D, Bimbo L, Taylor ME, Balkovetz DF, Barker J, et al. Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int.2002;61(3):1136-1142. doi:10.1046/j.1523-1755.2002.00201.x
  • 25. Türkmen E. Metastatic infectious complications in tunneled dialysis catheter-associated infections: a single-center experience. J Health Sci Med /JHSM /jhsm.2022;5(1):178-183. doi:10.32322/jhsm.1027252
  • 26. Yildirim S, Yilmaz B, Yilmaz E, Derici UB. Metastatic spondylodiscitis in central venous catheter related bloodstream infections in hemodialysis patients: Risk factors and prognosis. The Journal of Vascular Access. 2024;25(1):232-238. doi:10.1177/11297298221085460
  • 27. Tong SY, Fowler Jr VG, Skalla L, Holland T L. Management of Staphylococcus aureus bacteremia: a review. Jama.2025;334(9):798-808. doi:10.1001/jama.2025.4288
  • 28. Horino T, Hori S. Metastatic infection during Staphylococcus aureus bacteremia. Journal of Infection and Chemotherapy.2020;26(2):162–169. doi:10.1016/j.jiac.2019.10.003
  • 29. Bell ECN, Chapon V, Bessede E, Meriglier E, Issa N, Domblides C, Bonnet F. Central venous catheter-related bloodstream infections: Epidemiology and risk factors for hematogenous complications. Infectious Diseases Now,2024;54(3):104859. doi: 10.1016/j.idnow.2024.104859
  • 30. Horváth A, Dobay O, Sahin-Tóth J, Juhász E, Pongrácz J, Iván M, et al. Characterisation of antibiotic resistance, virulence, clonality and mortality in MRSA and MSSA bloodstream infections at a tertiary-level hospital in Hungary: a 6-year retrospective study. Annals of clinical microbiology and antimicrobials.2020;19(1):17. doi:10.1186/s12941-020-00357-z
  • 31. Vos FJ, Kullberg BJ, Sturm PD, Krabbe PFM, Van Dijk APJ, Wanten GJA, et al. Metastatic infectious disease and clinical outcome in Staphylococcus aureus and Streptococcus species bacteremia. Medicine (Baltim) 2012;91(2):86e94. doi:10.1097/MD.0b013e31824d7ed2
  • 32. Jensen AG, Espersen F, Skinhøj P, Frimodt-Møller N. Bacteremic Staphylococcus aureus spondylitis. Archives of internal medicine.1998;158(5):509-517. doi:10.1001/archinte.158.5.509
  • 33. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, et al. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases.2009;49(1):1–45. doi:10.1086/599376

Evaluation of Hospitalized Diagnosed with Catheter-Related Primary Bloodstream Infection in Our Clinic

Year 2026, Volume: 17 Issue: 1 , 104 - 115 , 20.04.2026
https://doi.org/10.22312/sdusbed.1717595
https://izlik.org/JA68ZZ63MC

Abstract

Introduction: Catheter related bloodstream infection (CRBSIs), among the most common, fatal and costly complications of central venous catheterization, are the leading cause of nosocomial bacteraemia. In hemodialysis patients, CRBSIs are the second most common cause of death after cardiovascular disease. These infections may cause metastatic complications such as infective endocarditis, spondylodiscitis and paravertebral abscess. The objective of this study was to evaluate CRBSIs and metastatic complications. Material and Methods: A retrospective evaluation included CRBSIs patients treated at the Department of Infectious Diseases and Clinical Microbiology. Demographic data, clinical symptoms, comorbidities, catheter characteristics, physical examination findings, isolated microorganisms and antibiotic susceptibility, inflammatory parameters and metastatic complications were recorded. Results: During the study period, a total of 63 episodes of CRBSIs were recorded in 51 patients. Of these, 54.9% were male, with a mean age of 60.7±16.2 years. In 82.4% of patients were received haemodialysis with dialysis catheter. All episodes, 85.7% were reported in patients on hemodialysis. Twenty complications were detected in 37.3% of the 51 patients. The most common complications were spondylodiscitis, infective endocarditis and psoas abscess. Gram-positive microorganisms were responsible for 85% of these complications and the most common pathogen was methicillin-susceptible Staphylococcus aureus. Conclusion: In addition to CRBSIs, infection-related complications were also more frequently observed in hemodialysis patients. Educating patients on catheter care and personal hygiene, implementing CRBSIs prevention packages in hospitals, and referring haemodialysis patients to the fistula option when possible may reduce the incidence of these complications.

References

  • 1. Blanchard AC, Fortin E, Rocher I, Moore DL, Frenette C, Tremblay C, et al. Central line-associated bloodstream infection in neonatal intensive care units. Infect Control Hosp Epidemiol. 2013;34(11):1167–1173. doi:10.1086/673464
  • 2. Allon M. Dialysis catheter-related bacteremia: treatment and prophylaxis. American Journal of Kidney Diseases. 2004;44(5):779-791.doi.org/10.1053/j.ajkd.2004.07.005
  • 3. Lewis SS, Sexton DJ. Metastatic Complications of Bloodstream Infections in Hemodialysis Patients. Seminars in Dialysis. 2013;26(1): 47-53. doi:10.1111/sdi.12031
  • 4. Jackson SS, Leekha S, Magder LS, Pineles L, Anderson DJ, Trick WE, et al. The effect of adding comorbidities to current centers for disease control and prevention central-line-associated bloodstream infection risk-adjustment methodology. Infect Control Hosp Epidemiol.2017;38(9):1019–1024. doi:10.1017/ice.2017.129
  • 5. Pepin CS, Thom KA, Sorkin JD, Leekha S, Masnick M, Preas MA, et al. Risk factors for central-line-associated bloodstream infections: a focus on comorbid conditions. Infect Control Hosp Epidemiol. 2015;36(4):479–481. doi:10.1017/ice.2014.81
  • 6. Alshahrani KM, Alhuwaishel AZ, Alangari NM, Asiri MA, Al-Shahrani NA, Alasmari AA, et al. Clinical Impacts and Risk Factors for Central Line-Associated Bloodstream Infection: A Systematic Review. Cureus. 2023;15(6):e40954. doi:10.7759/cureus.40954
  • 7. See I, Freifeld AG, Magill SS. Causative Organisms and Associated Antimicrobial Resistance in Healthcare-Associated, Central Line-Associated Bloodstream Infections From Oncology Settings, 2009-2012. Clinical Infectious Diseases.2016;62(10):1203–1209. doi:10.1093/cid/ciw113
  • 8. Aydın M, Kaşıkçıoğlu C, Nargiz Koşucu S, Timurkaynak F, Arslan H. Kan Dolaşımı İnfeksionu Etkenleri ve Antibiyotik Direnç Oranları Klimik Journal/Klimik Dergisi.2016;29(2): doi: 10.5152/kd.2016.19
  • 9. Shingarev R, Barker-Finkel J, Allon M. Natural history of tunneled dialysis catheters placed for hemodialysis initiation. J Vasc Interv Radiol. 2013;24(9):1289-1294. doi:10.1016/j.jvir.2013.05.034
  • 10. Farrington CA, Allon M. Management of the Hemodialysis Patient with Catheter-Related Bloodstream Infection. Clin J Am Soc Nephrol. 2019;14(4):611-613. doi:10.2215/CJN.13171118
  • 11. Novosad SA, Fike L, Dudeck MA, Allen-Bridson K, Edwards JR, Edens C, et al. Pathogens causing central-line-associated bloodstream infections in acute-care hospitals-United States, 2011-2017. Infection control and hospital epidemiology.2020;41(3):313–319. doi:10.1017/ice.2019.303
  • 12. Engemann JJ, Friedman JY, Reed SD, Griffiths RI, Szczech LA, Kaye KS, et al. Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis. Infection control and hospital epidemiology. 2005;26(6):534–539. doi:10.1086/502580
  • 13. Farrington CA, Allon M. Complications of Hemodialysis Catheter Bloodstream Infections: Impact of Infecting Organism. American journal of nephrology.2019;50(2):126–132. doi:10.1159/000501357
  • 14. European Committee on Antimicrobial Susceptibility Testing (2023)[Internet]. Breakpoint tables for interpretation of MICs and zone diameters. Version 13.0.; 2023 Oct 2 [cited 2025 Apr 17]. Available from: http://www.eucast.org
  • 15. Guo H, Zhang L, He H, Wang L. Risk factors for catheter-associated bloodstream infection in hemodialysis patients: A meta-analysis. PLoS One.2024;19(3):e0299715. doi:10.1371/journal.pone.0299715
  • 16. Al-Solaiman Y, Estrada E, Allon M. The spectrum of infections in catheter-dependent hemodialysis patients. Clinical journal of the American Society of Nephrology:CJASN.2011;6(9):2247–2252. doi:10.2215/CJN.03900411
  • 17. Arslan M, Kahraman E, Menekşe E. Tunneled Catheter‐Related Bloodstream Infections in Chronic Hemodialysis Patients: Frequency, Risk Factors, and Outcomes—A 10‐Year Analysis. Apmis.2025;133(3): e70016. doi:10.1111/apm.70016
  • 18. İnce N, Yekenkurul D, Çalışkan E, Gürbüz AR, Yener S. Investigation of the Factors Associated with Mortality in Catheter-Related Bloodstream Infections: Five-Year Observation. Duzce Medical Journal.2020;22(3):149-153. doi:10.18678/dtfd.746887
  • 19. Agrawal V, Valson AT, Mohapatra A, David VG, Alexander S, Jacob S, et al. Fast and furious: a retrospective study of catheter-associated bloodstream infections with internal jugular nontunneled hemodialysis catheters at a tropical center, Clinical Kidney Journal.2019;12(5):737–744. doi:10.1093/ckj/sfy138
  • 20. Özkan P, Güney İ, Karakose S, Topal M, Erkuş E, Tarakcı A. The evaluation of catheter infections in kidney disease patients. J Contemp Med.2021;11(1):69-74. doi:10.16899/jcm.734057
  • 21. Timsit JF, Rupp M, Bouza, E, Chopra V, Kärpänen T, Laupland K, et al. A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill. Intensive Care Med.2018;44(6): 742–759. doi:10.1007/s00134-018-5212-y
  • 22. Baang JH, Inagaki K, Nagel J, Ramani K, Stillwell TL, Mack M, et al. Inpatient Diagnosis and Treatment of Catheter-Related Bloodstream Infection [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK589895/
  • 23. Chaves F, Garnacho-Montero J, Del Pozo JL, Bouza E, Capdevila, JA, de Cueto M, et al. Executive summary: Diagnosis and Treatment of Catheter-Related Bloodstream Infection: Clinical Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) and the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC). Enfermedades infecciosas y microbiologia clinica (English ed.).2018;36(2):112–119. doi:10.1016/j.eimc.2017.10.019
  • 24. Krishnasami Z, Carlton D, Bimbo L, Taylor ME, Balkovetz DF, Barker J, et al. Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int.2002;61(3):1136-1142. doi:10.1046/j.1523-1755.2002.00201.x
  • 25. Türkmen E. Metastatic infectious complications in tunneled dialysis catheter-associated infections: a single-center experience. J Health Sci Med /JHSM /jhsm.2022;5(1):178-183. doi:10.32322/jhsm.1027252
  • 26. Yildirim S, Yilmaz B, Yilmaz E, Derici UB. Metastatic spondylodiscitis in central venous catheter related bloodstream infections in hemodialysis patients: Risk factors and prognosis. The Journal of Vascular Access. 2024;25(1):232-238. doi:10.1177/11297298221085460
  • 27. Tong SY, Fowler Jr VG, Skalla L, Holland T L. Management of Staphylococcus aureus bacteremia: a review. Jama.2025;334(9):798-808. doi:10.1001/jama.2025.4288
  • 28. Horino T, Hori S. Metastatic infection during Staphylococcus aureus bacteremia. Journal of Infection and Chemotherapy.2020;26(2):162–169. doi:10.1016/j.jiac.2019.10.003
  • 29. Bell ECN, Chapon V, Bessede E, Meriglier E, Issa N, Domblides C, Bonnet F. Central venous catheter-related bloodstream infections: Epidemiology and risk factors for hematogenous complications. Infectious Diseases Now,2024;54(3):104859. doi: 10.1016/j.idnow.2024.104859
  • 30. Horváth A, Dobay O, Sahin-Tóth J, Juhász E, Pongrácz J, Iván M, et al. Characterisation of antibiotic resistance, virulence, clonality and mortality in MRSA and MSSA bloodstream infections at a tertiary-level hospital in Hungary: a 6-year retrospective study. Annals of clinical microbiology and antimicrobials.2020;19(1):17. doi:10.1186/s12941-020-00357-z
  • 31. Vos FJ, Kullberg BJ, Sturm PD, Krabbe PFM, Van Dijk APJ, Wanten GJA, et al. Metastatic infectious disease and clinical outcome in Staphylococcus aureus and Streptococcus species bacteremia. Medicine (Baltim) 2012;91(2):86e94. doi:10.1097/MD.0b013e31824d7ed2
  • 32. Jensen AG, Espersen F, Skinhøj P, Frimodt-Møller N. Bacteremic Staphylococcus aureus spondylitis. Archives of internal medicine.1998;158(5):509-517. doi:10.1001/archinte.158.5.509
  • 33. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, et al. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases.2009;49(1):1–45. doi:10.1086/599376
There are 33 citations in total.

Details

Primary Language Turkish
Subjects Infectious Diseases
Journal Section Research Article
Authors

Tuğçe Ertuğrul 0000-0003-2805-9402

Gülruhsar Yılmaz 0000-0001-5878-4301

Onur Ünal 0000-0002-0409-4476

Esra Nurlu Temel 0000-0003-4618-168X

Onur Kaya 0000-0001-9292-2608

Füsun Zeynep Akçam 0000-0002-8691-035X

Submission Date June 12, 2025
Acceptance Date March 2, 2026
Publication Date April 20, 2026
DOI https://doi.org/10.22312/sdusbed.1717595
IZ https://izlik.org/JA68ZZ63MC
Published in Issue Year 2026 Volume: 17 Issue: 1

Cite

Vancouver 1.Tuğçe Ertuğrul, Gülruhsar Yılmaz, Onur Ünal, Esra Nurlu Temel, Onur Kaya, Füsun Zeynep Akçam. Kliniğimizde Yatarak İzlenen Kateter İlişkili Kan Dolaşımı İnfeksiyonu Tanılı Hastaların Değerlendirilmesi. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2026 Apr. 1;17(1):104-15. doi:10.22312/sdusbed.1717595