Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler

Erkan Aksöz

doi:10.22312/sdusbed.421087

Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler

Abstract

Özet

Deneysel epilepsi modellerinde ve epilepsi hastalarında yapılan klinik çalışmalar sonucunda, nöroinflamasyonun epilepsi patofizyolojisinde etkin bir rolü olduğuna dair önemli kanıtlar elde edilmiştir. Özellikle, nöroinflamasyonla ilişkili yolaklar ve mediyatörlerin epileptogenez sürecindeki etkisi yoğun araştırma konusu olmuş, antiepileptojenik tedavilerin ve epileptojenik biyobelirteçlerin geliştirilebilmesi için bu süreçlerin aydınlatılması önem kazanmıştır. Bu çalışmalar sonucunda birçok patofizyolojik süreç incelenmiş ve antiepileptojenik tedavi hedefleri tanımlanmıştır. Bu derlemede epileptogenez sürecinde nöroinflamasyon ile ilişkili başlıca mekanizmalar ele alınmış, antiepileptojenik tedavi geliştirilmesi odaklı olarak potansiyel hedefler gözden geçirilmiştir.

Abstract

Research in experimental epilepsy models and clinical investigations on epilepsy patients have provided important evidence that neuroinflammation has an effective role in epilepsy pathophysiology. Particularly, the effects of neuroinflammation-related pathways and mediators in the epileptogenesis process have been the subject of intensive research, and the elucidation of these processes has become important for the development of antiepileptogenic therapies and epileptogenic biomarkers. As a result of these studies, many pathophysiological processes have been determined and antiepileptogenic therapeutic targets have been defined. In this review, the main mechanisms involved in neuroinflammation in the epileptogenesis process are addressed and potential targets are reviewed focusing on developing antiepileptogenic therapy.

Keywords

Nöroinflamasyon,Epileptogenez,Epilepsi,Antiepileptojenik

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Erkan Aksöz ^*
Türkiye

Publication Date

August 1, 2018

Submission Date

May 4, 2018

Acceptance Date

May 10, 2018

Published in Issue

Year 2018 Volume: 9 Number: 2

DOI

https://doi.org/10.22312/sdusbed.421087

IZ

https://izlik.org/JA24WP78RP

Cite

RIS / Bibtex

APA

Aksöz, E. (2018). Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 9(2), 130-135. https://doi.org/10.22312/sdusbed.421087

AMA

1.Aksöz E. Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018;9(2):130-135. doi:10.22312/sdusbed.421087

Chicago

Aksöz, Erkan. 2018. “Nöroinflamasyonun Epileptogenezdeki Rolü Ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 9 (2): 130-35. https://doi.org/10.22312/sdusbed.421087.

EndNote

Aksöz E (August 1, 2018) Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 9 2 130–135.

IEEE

[1]E. Aksöz, “Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler”, Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol. 9, no. 2, pp. 130–135, Aug. 2018, doi: 10.22312/sdusbed.421087.

ISNAD

Aksöz, Erkan. “Nöroinflamasyonun Epileptogenezdeki Rolü Ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 9/2 (August 1, 2018): 130-135. https://doi.org/10.22312/sdusbed.421087.

JAMA

1.Aksöz E. Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018;9:130–135.

MLA

Aksöz, Erkan. “Nöroinflamasyonun Epileptogenezdeki Rolü Ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol. 9, no. 2, Aug. 2018, pp. 130-5, doi:10.22312/sdusbed.421087.

Vancouver

1.Erkan Aksöz. Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018 Aug. 1;9(2):130-5. doi:10.22312/sdusbed.421087

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