2.45 gigahertz elektromanyetik radyasyonun böbrekteki histopatolojik etkileri ve C vitamininin koruyucu etkisi

Yıl 2018, , 1 - 5, 25.12.2018

Ercan Baş , Murat Uçar , Funda Yıldırım Baş , Şükriye Yeşilot , İlkay Armağan , Arzu Yalçın

https://doi.org/10.22312/sdusbed.479744

Öz

Amaçlar: Elektromanyetik radyasyonun (EMR) sıçan böbreğinde yol
açtığı histopatolojik hasarı ve C vitamininin (askorbik asit) oluşan bu renal
hasara karşı iyileştirici etkilerini araştırmak.

Gereç ve Yöntemler: On sekiz dişi Sprague-Dawley sıçanı, her biri altı
sıçan olmak üzere üç gruba ayrıldı. Grup 1 şam grubuydu; bu sıçanlar herhangi bir stres
veya elektromanyetik radyasyona maruz kalmadan kafeslerinde tutuldu. Grup 2, 30
gün boyunca 2.45 gigahertz elektromanyetik radyasyona maruz bırakıldı. Grup 3
de 30 gün boyunca (günde 1 saat) 2.45 gigahertz elektromanyetik radyasyona
maruz bırakıldı, ancak ilk maruziyetinden 24 saat önce ve deney boyunca her gün
C vitamini verildi. Tüm sıçanlara histopatolojik inceleme için nefrektomi
yapıldı.

Bulgular: Şam grubunda herhangi bir patolojik değişiklik olmadı.
Grup 2’de tübüler ve glomerüler hasarı içeren önemli patolojik değişiklikler
izlendi (P<0.05). İnterstisyel ve vasküler hasar açısından grup 2 ve 3’te
önemli bir değişiklik izlenmedi (P>0.05). Tübüler ve glomerüler hasar grup
3’te grup 2’ye göre daha az şiddetliydi (P<0.05). Şam grubu ve grup 3
arasında tübüler, glomerüler, interstisyel ve vasküler hasar açısından önemli
bir farklılık izlenmedi (P>0.05).

Sonuç: Elektromanyetik radyasyonun böbrekte yol açtığı
tübüler ve glomerüler hasar, elektromanyetik radyasyon maruziyeti öncesi alınan
C vitamini ile neredeyse tamamen normale dönmektedir.

Anahtar Kelimeler

Antioksidanlar, Askorbik asit, Elektromanyetik radyasyon, Böbrek, Oksidatif stres

Histopathological Effects of 2.45 Gigahertz Electromagnetic Radiation on the Kidney, and Protective Effects of Vitamin C

Öz

Objectives: To investigate the effects of electromagnetic
radiation (EMR) on the kidneys based on histopathological changes of renal
damage, and to investigate the ameliorating effects of vitamin C (ascorbic
acid) against EMR-induced renal damage in rats.

Materials
and Methods: Eighteen female Sprague-Dawley rats were divided into
three groups of six rats each. Group 1 was the sham group; these rats were kept
in their cages without stress or electromagnetic radiation exposure. Group 2
was exposed to 2.45 gigahertz electromagnetic radiation for 30 days. Group 3
was also exposed to 2.45 gigahertz electromagnetic radiation for 30 days (1
h/day) but received vitamin C 24 hours prior to the first exposure and daily
throughout the experiment. All rats underwent nephrectomy with
histopathological examination.

Results: There were no pathological findings in the sham
group. Significant pathological changes were observed in group 2, including
tubular and glomerular damage (P<0.05). Interstitial and vascular damage was
not significantly different between groups 2 and 3 (P>0.05). Tubular and glomerular damage was less severe in group
3 than in group 2 (P<0.05). There was no
significant difference between the sham group and group 3 in terms of tubular,
glomerular, interstitial, or vascular damage (P>0.05).

Conclusion: Electromagnetic radiation-induced tubular and
glomerular damage in the kidney was almost completely reversed with the administration
of vitamin C before electromagnetic radiation exposure.

Anahtar Kelimeler

Antioxidants, Ascorbic Acid, Electromagnetic Radiation, Kidney, Oxidative stress

Kaynakça

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