Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri

Meltem Mermer; Hilal Yıldıran

doi:10.22312/sdusbed.626176

Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri

Abstract

Parkinson hastalığı (PH) bilişsel ve motor semptomları içeren nörodejeneratif bir hastalıktır. Beyinin vücuttaki en yağlı ve yüksek oranda kolesterol içeren bir organ olması nedeniyle normal fonksiyonlarını sürdürülmek için yağlara ve kolesterole ihtiyaç duyar. Elzem yağ asitleri beynin birçok hücresel fonksiyonunda rol almaktadır. Linoleik asit ve α-linolenik asit vücut tarafından sentezlenemediği için elzem yağ asitleri olup diyet ile alınmalıdır. Bu iki esansiyel yağ asidi daha uzun zincirli çoklu doymamış yağ asitlerinin (PUFA) sentezi için öncüdürler. Beyin serbest PUFA seviyeleri oksidatif stres ve inflamasyon bağlı olarak artmaktadır. Ayrıca oksidatif stres beyinde yüksek seviyelerde bulunan DHA ve AA’in peroksidasyonuna ve bunun sonucunda da dopaminerjik sistem nörodejenerasyonuna neden olmaktadır. Diyetin esansiyel yağ asidi içeriği nörotransmitter sistemleri etkilemektedir. Kronik omega-3 (w-3) yağ asidi eksikliği dopamin reseptörü bağlanmasında azalmaya, serotonin reseptörü yoğunluğunda artışa ve dopamin metabolizmasında değişikliklere neden olabilirken substantia nigrada görülen dopaminerjik nöron kaybının az da olsa DHA tarafından önlendiği deneysel olarak gösterilmiştir. Beyin fonksiyonlarının devamlılığı için önemli olan kolesterolün de kanda normal seviyelerin üstüne çıkması beyinde oksidatif stresi ve buna bağlı olarak PH riskini arttırabilir. Diyet esansiyel yağ asitleri ve kolesterol seviyesi ile PH gelişimi riski arasındaki ilişkiyi inceleyen çalışmaların birbirleri ile çelişen sonuçları bulunmaktadır. Bu nedenle esansiyel yağ asitleri ve kolesterolün PH’nın oluşumu, önlemesi ve/veya semptomları azaltma etkisi konularını kesinleştirecek daha geniş çaplı araştırmalara ihtiyaç vardır.

Keywords

Parkinson hastalığı,esansiyel yağ asitleri

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Meltem Mermer ^*
0000-0001-5264-3356
Türkiye

Hilal Yıldıran This is me
0000-0001-7956-5087
Türkiye

Publication Date

March 3, 2020

Submission Date

September 27, 2019

Acceptance Date

February 13, 2020

Published in Issue

Year 2020 Volume: 11 Number: 1

DOI

https://doi.org/10.22312/sdusbed.626176

IZ

https://izlik.org/JA84RJ33FD

Cite

RIS / Bibtex

APA

Mermer, M., & Yıldıran, H. (2020). Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 11(1), 120-126. https://doi.org/10.22312/sdusbed.626176

AMA

1.Mermer M, Yıldıran H. Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020;11(1):120-126. doi:10.22312/sdusbed.626176

Chicago

Mermer, Meltem, and Hilal Yıldıran. 2020. “Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri Ve Kolesterolün Etkileri”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 11 (1): 120-26. https://doi.org/10.22312/sdusbed.626176.

EndNote

Mermer M, Yıldıran H (March 1, 2020) Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 11 1 120–126.

IEEE

[1]M. Mermer and H. Yıldıran, “Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri”, Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol. 11, no. 1, pp. 120–126, Mar. 2020, doi: 10.22312/sdusbed.626176.

ISNAD

Mermer, Meltem - Yıldıran, Hilal. “Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri Ve Kolesterolün Etkileri”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 11/1 (March 1, 2020): 120-126. https://doi.org/10.22312/sdusbed.626176.

JAMA

1.Mermer M, Yıldıran H. Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020;11:120–126.

MLA

Mermer, Meltem, and Hilal Yıldıran. “Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri Ve Kolesterolün Etkileri”. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol. 11, no. 1, Mar. 2020, pp. 120-6, doi:10.22312/sdusbed.626176.

Vancouver

1.Meltem Mermer, Hilal Yıldıran. Parkinson Hastalığı Patogenezinde Esansiyel Yağ Asitleri ve Kolesterolün Etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020 Mar. 1;11(1):120-6. doi:10.22312/sdusbed.626176