Comparison of Paricalcystol and Calcitriol Treatment in terms of inflammation in Hemodialysis Patients

Abstract

Abstract Objective: Chronic kidney disease is a multisystemic, inflammatory disease. Although atherosclerotic heart disease is the most important cause of mortality in hemodialysis patients, malnutrition and inflammation constitute an additional risk factor in this patient group. In this study, we aimed to investigate inflammation among hemodialysis patients using paricalcitol and calcitriol. Material-Method: This study was carried out retrospectively, cross-sectionally and descriptively. From the 241 hemodialysis patients; 30 patients were included in the paricalcitol group and 58 patients were included in the calcitriol group. Neutrophil lymphocyte ratio (NLO), high sensitivity C reactive protein (hs-CRP), important clinical and laboratory data were recorded. Pearson correlation test was applied to show the relationship between NLO and hs-CRP. Results: 59 of the patients were male and 29 were female. The mean age was 62.9 ± 14.8 years in the paricalcitol group and 59 ± 13.9 years in the calcitriol group (p: 0.20). The concentration of NLO and hs-CRP was similar in the paricalcitol and calcitriol group (p: 0.42, p: 0.51, respectively). There was no significant difference between groups in terms of albumin and ferritin levels (p: 0.55, p: 0.68, respectively). A positive correlation was found between NLO and hs-CRP (r: 0.471, p: 0.001). Conclusion: Although hemodialysis patients included in the study had a positive relationship between NLO, which can be obtained easily and cheaply from complete blood count, and hs-CRP, there was no difference in terms of inflammation between the groups receiving paricalcitol and calcitriol treatment. Considering our study, prospective studies involving more patients are needed.

Keywords

• Hemodialysis
• inflammation
• neutrophil/lymphocyte ratio
• paricalcitol
• calcitriol

Hemodiyaliz Hastalarında Parikalsitol ve Kalsitriol Tedavisinin İnflamasyon Açısından Karşılaştırılması

Abstract

Özet Amaç: Kronik böbrek hastalığı multisistemik, inflamatuar bir hastalıktır. Hemodiyaliz hastalarında aterosklerotik kalp hastalığı mortalitenin en önemli nedeni olmasına rağmen malnutrisyon ve inflamasyon bu hasta grubunda ek risk faktörü oluşturur. Bu çalışmada parikalsitol ile kalsitriol kullanan hemodiyaliz hastaları arasında inflamasyonun incelenmesi amaçlandı. Materyal-Metod: Bu çalışma retrospektif, kesitsel ve tanımlayıcı olarak gerçekleştirildi. Çalışmaya hemodiyaliz tedavisi alan 241 hastadan parikalsitol grubuna 30 ve kalsitriol grubuna 58 hasta olacak şekilde dahil edildi. Nötrofil lenfosit oranı (NLO), yüksek duyarlıklı C reaktif protein (hs-CRP) ve önemli klinik ve laboratuvar veriler kaydedildi. NLO ve hs-CRP arasındaki ilişkiyi göstermek için pearson korelasyon testi uygulandı. Bulgular: Hastaların 59’u erkek 29’u kadınlardan oluşmaktaydı. Yaş ortalaması parikalsitol grubunda 62.9±14.8 kalsitriol grubunda 59±13.9 yıldı (p:0.20). NLO ve hs-CRP konsantrasyonu parikalsitol ve kalsitriol grubunda benzerdi (sırasıyla p:0.42, p:0.51). Gruplar arasında albümin ve ferritin düzeyleri açısından anlamlı fark saptanmadı (sırasıyla p:0.55, p:0.68). NLO ile hs-CRP arasında pozitif bir korelasyon saptandı (r:0.471, p:0.001). Sonuç: Çalışmaya dahil edilen hemodiyaliz hastalarında, kolay ve ucuz olarak tam kan sayımından elde edilebilen NLO ile hs-CRP arasında pozitif bir ilişki saptanmasına rağmen parikalsitol ve kalsitriol tedavisi alan gruplar arasında inflamasyon açısından bir fark saptanmadı. Bizim yaptığımız çalışmaya dayanarak daha yüksek hasta popülasyonunun dahil edildiği prospektif araştırmalara ihtiyaç vardır.

Keywords

• Hemodiyaliz
• inflamasyon
• nötrofil/lenfosit oranı
• parikalsitol
• kalsitriol

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