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Endodontik Tıp: Sistemik Hastalıkların Pulpal ve Periapikal Dokular ile İlişkisi

Yıl 2021, , 250 - 260, 20.08.2021
https://doi.org/10.22312/sdusbed.902355

Öz

Endodontik enfeksiyonlar ile sistemik hastalıklar arasındaki çift yönlü ilişkiyi ele alan “Endodontik Tıp”, her geçen gün daha fazla önem kazanmaktadır. Sistemik hastalıklar endodontik enfeksiyonların patogenezini etkileyebilirken, endodontik enfeksiyonun da sistemik değişikliklere neden olabileceğini gösteren çok sayıda kanıt vardır. Diyabet, kardiyovasküler hastalıklar, renal ve romatoit hastalıklar ve hipoöstrojenemi gibi sistemik hastalıkların pulpa ve periodonsiyumda yarattıkları değişiklikler incelenmektedir. Bu değişiklikler, periapikal bölgede daha şiddetli bir kemik rezorpsiyonu ve enflamasyonun yanı sıra sistemik hastalığın ilerlemesi şeklinde de olabilir. 1800’lerden 1950’lere kadar oral enfeksiyonun sistemik hastalıkla direkt ilişkisini savunan fokal enfeksiyon teorisi nedeniyle diş ve tonsilla gibi organların uzaklaştırılması öneriliyordu. Bu durumun daha sonra kesin bir dil ile reddedilmesine karşın, yeni çalışmalar ışığında sistemik ve pulpal ilişkinin keskin sınırlarla ayrılamayacağı anlaşılmaktadır. Bu derlemenin amacı, sistemik hastalıklar ile endodontik enfeksiyon arasındaki çift taraflı ilişkiyi ortaya koyan literatürü analiz etmek ve bu bağlantıların sistemik sağlık durumu ile endodontik tedavi sonuçlarına nasıl etki edebileceğini belirlemektir.

Kaynakça

  • Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history? Endodontic Topics 2003; 4: 32–45.
  • Seymour RA. Is gum disease killing your patient? British Dental Journal 2009; 206:551–2.
  • Segura‐Egea JJ, Martín‐González J, Castellanos‐Cosano L. Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J 2015; 48.10: 933-51.
  • Aminoshariae A et al. Association between systemic diseases and endodontic outcome: a systematic review. J Endod, 2017; 43.4: 514-9.
  • Kohsaka T et al. Periapical lesions in rats with streptozotocin-induced diabetes. J Endod, 1996, 22.8: 418-21.
  • Azuma MM et al. Omega 3 fatty acids reduce bone resorption while promoting bone generation in rat apical periodontitis. J Endod 2017, 43.6: 970-6.
  • Segura-Egea JJ, Jiménez-Pinzón A, Ríos-Santos JV et al. High prevalence of apical periodontitis amongst type 2 diabetic patients. Int Endod J. 2005; 38(8): 564-9.
  • López-López J, Jané-Salas E, Estrugo-Devesa A et al. Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study. J Endod. 2011; 37(5): 598-601.
  • Dinç, V. Sağlıklı Bı̇reylerle Tı̇p 2 Dı̇yabetes Mellituslu Bı̇reylerı̇n Perı̇apı̇kal Durumunun ve Endodontı̇k Tedavı̇ Kalı̇tesı̇nı̇n Karşılaştırılması. Uzmanlık Tezi, Isparta Süleyman Demirel Üniversitesi,Endodonti AD. Danışman:Prof. Dr. Ayşe Diljin Keçeci 2016.
  • Taç, G. Tip II diyabetin farklı tanılara sahip dişlerde endodontik mikrofloraya etkisinin incelenmesi. Doktora Tezi, Isparta Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü 2008, Endodonti AD, Danışman:Prof. Dr. Ayşe Diljin Keçeci.
  • Marotta PS, Fontes TV, Armada L et al. Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population. J Endod. 2012; 38(3): 297-300.
  • Fouad AF, Burleson J. The effect of diabetes mellitus on endodontic treatment outcome: data from an electronic patient record. J Am Dent Assoc. 2003; 134(1): 43-51.
  • Britto LR, Katz J, Guelmann M et al. Periradicular radiographic assessment in diabetic and control individuals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 96(4): 449-52.
  • Tibúrcio-Machado CD, Bello MC, Maier J et al. Influence of diabetes in the development of apical periodontitis: a critical literature review of human studies. J Endod. 2017; 43(3): 370-6.
  • Segura-Egea JJ, Martín-González J, Cabanillas-Balsera D et al. Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis. Clin Oral Investig. 2016; 20(6): 1133-41.
  • Arya S, Duhan J, Tewari S et al. Healing of apical periodontitis after nonsurgical treatment in patients with type 2 diabetes. J Endod 2017; 43: 1623–7.
  • Schulze A, Schönauer M, Busse M. Sudden improvement of insulin sensitivity related to an endodontic treatment. J Periodontol 2007; 78.12: 2380-2384.
  • Maat MP, Kluft C. Determinants of C-reactive protein concentration in blood. Italian Heart Journal 2001; 2: 189–95.
  • Segura-Egea JJ, Jimenez-Moreno E, Calvo-Monroy C et al. Hypertension and dental periapical condition. J Endod. 2010; 36(11): 1800-4.
  • Pasqualini D, Bergandi L, Palumbo L et al. Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults. J Endod. 2012; 38(12): 1570-7.
  • Cosme-Silva, Leopoldo, et al. Hypertension affects the biocompatibility and biomineralization of MTA, High-plasticity MTA, and Biodentine. Braz Oral Res 2019; 33.
  • Abdolsamadi HR, Vahedi M, Esmaelli F et al. Serum interleukin-6 as a serologic marker of chronic periapical lesions: a case-control study. J Dent Res, Dental Clinics, Dental Prospects 2008; 2: 43–7.
  • Proctor ME, Turner DW, Kaminski EJ et al. Determination and relationship of C-reactive protein in human dental pulps and in serum. J Endod 1991; 17: 265–270.
  • Márton I, Kiss C, Balla G et al. Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. Oral Microbiol Immunol, 1988; 3.2: 95-96.
  • Ren, Yan-Fang; Malmstrom, Hans S. Rapid quantitative determination of C-reactive protein at chair side in dental emergency patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104.1: 49-55. Vidal F, Fontes TV, Marques TV et al. Association between apical periodontitis lesions and plasmatic levels of C‐reactive protein, interleukin 6 and fibrinogen in hypertensive patients Int Endod J. 2016: 49.12: 1107-1115.
  • Joshipura KJ, Wand HC, Merchant AT et al. Periodontal disease and biomarkers related to cardiovascular disease. J Dent Res. 2004; 83(2): 151-5.
  • Messing M, Souza LC, Cavalla F et al. Investigating Potential Correlations between Endodontic Pathology and Cardiovascular Diseases Using Epidemiological and Genetic Approaches. J Endod. 2019; 45.2: 104-110.
  • Ren H, Du M. Role of maternal periodontitis in preterm birth. Frontiers in Immunology 2017; 8:139.
  • Bain JL, Lester SR, Henry WD et al. Effects of induced periapical abscesses on rat pregnancy outcomes. Archives of Oral Biology 2009; 54: 162-71.
  • Ao M, Miyauchi M, Furusho H et al. Dental infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One 2015; 10: e0137249.
  • Tsosura TVS, Chiba FY, Mattera MSLC et al. Maternal apical periodontitis is associated with insulin resistance in adult offspring. Int Endod J 2019.
  • Alam Q, Alam MZ, Mushtaq G et al. Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines. Current Pharmaceutical Design 2016; 22: 541-8. Florencio-Silva R, Sasso GRS, Sasso-Cerri E et al. Effects of estrogen status in osteocyte autophagy and its relation to osteocyte viability in alveolar process of ovariectomized rats. Biomedicine & Pharmacotherapy 2018; 98: 406-415.
  • Romualdo PC, Lucisano MP, Paula-Silva FWG et al. Ovariectomy Exacerbates Apical Periodontitis in Rats with an Increase in Expression of Proinflammatory Cytokines and Matrix Metalloproteinases. J Endod 2018; 44: 780-5.
  • Malmström M. Immunoglobulin classes IgG, IgM, IgA and complement component C3 in dental periapical lesions of patients with rheumatoid disease. Scand J Rheumatol 1975; 4: 57–64.
  • Jalali P, Hasselgren G. Endodontic inter-appointment flare-ups: An example of chaos? Dent Hypotheses 2015; 6: 44–8.
  • Elkins DA, Torabinejad M, Schmidt RE et al. Polymerase chain reaction detection of human immunodeficiency virus DNA in human periradicular lesions. J Endod 1994; 20.8: 386-388.
  • Gerner NW, Hurlen B, Dobloug J et al. Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. Endod Dent Traumatol 1988; 4: 127–131.
  • Fontes TV; Marques FV, Gonçalves LS. Endodontic infection in HIV-infected individuals: An overview. Endodontic Practice Today, 2015; 9.1.
  • Ouies HS, Casamassimo OS, da Fonseca M. Sickle cell anemia: a review for the pediatric dentist. Pediatr Dent 2007; 29: 159–69.
  • Hebbel RP, Vercellotti GM, Nath KA. A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxis. Cardiovasc Hematol Disord Drug Targets 2009; 9: 271–92.
  • Al-Jafar H, Dashti H, Al-Haddad SJ et al. Dental alterations in sickle cell disease. J Dent Oral Care Med 2016; 2: 203.
  • Vgontzas A, Charleston IVL, Robbins MS. Headache and facial pain in sickle cell disease. Curr Pain Headache Rep 2016; 20: 1–10.
  • Costa CPS, Thomaz EBA, Souza SFC. Association between sickle cell anemia and pulp necrosis. J Endod 2013; 39: 177–81.
  • Movahhedian N, Haghnegahdar A, Owji F. How the prevalence of pulp stone in a population predicts the risk for kidney stone. Iran Endod J 2018; 13: 246–50.
  • Gabardo MCL, Wambier LM, Rocha JS et al. Association between Pulp Stones and Kidney Stones: A Systematic Review and Meta-analysis. J Endod. 2019 Sep;45(9):1099-1105.

Endodontic Medicine: The Relation of Systemic Diseases with Pulpal and Periapical Tissues

Yıl 2021, , 250 - 260, 20.08.2021
https://doi.org/10.22312/sdusbed.902355

Öz

"Endodontic Medicine", which deals with the bidirectional relationship between endodontic infections and systemic diseases, gains more and more importance day by day. While systemic diseases can affect the pathogenesis of endodontic infections, there is abundant evidence that endodontic infection can also cause systemic changes. The changes in the pulp and periodontium caused by systemic diseases such as diabetes, cardiovascular diseases, renal and rheumatoid diseases, and hypoestrogenemia have been investigated. These changes may be in the form of a more severe bone resorption and inflammation in the periapical region, as well as progression of the systemic disease. From the 1800s until the 1950s, the removal of organs such as teeth and tonsils was recommended according to the focal infection theory, which advocated the existence of a direct relationship between oral infection and systemic disease. Although this situation was later denied with a definite language, in the light of the new studies, it is understood that the relationship between systemic and pulpal health cannot be separated by a sharp boundary. The purpose of this review was to analyze the literature that reveals the bidirectional associaton between systemic diseases and endodontic infection and to determine how these connections may affect systemic health status and endodontic treatment outcomes.

Kaynakça

  • Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history? Endodontic Topics 2003; 4: 32–45.
  • Seymour RA. Is gum disease killing your patient? British Dental Journal 2009; 206:551–2.
  • Segura‐Egea JJ, Martín‐González J, Castellanos‐Cosano L. Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J 2015; 48.10: 933-51.
  • Aminoshariae A et al. Association between systemic diseases and endodontic outcome: a systematic review. J Endod, 2017; 43.4: 514-9.
  • Kohsaka T et al. Periapical lesions in rats with streptozotocin-induced diabetes. J Endod, 1996, 22.8: 418-21.
  • Azuma MM et al. Omega 3 fatty acids reduce bone resorption while promoting bone generation in rat apical periodontitis. J Endod 2017, 43.6: 970-6.
  • Segura-Egea JJ, Jiménez-Pinzón A, Ríos-Santos JV et al. High prevalence of apical periodontitis amongst type 2 diabetic patients. Int Endod J. 2005; 38(8): 564-9.
  • López-López J, Jané-Salas E, Estrugo-Devesa A et al. Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study. J Endod. 2011; 37(5): 598-601.
  • Dinç, V. Sağlıklı Bı̇reylerle Tı̇p 2 Dı̇yabetes Mellituslu Bı̇reylerı̇n Perı̇apı̇kal Durumunun ve Endodontı̇k Tedavı̇ Kalı̇tesı̇nı̇n Karşılaştırılması. Uzmanlık Tezi, Isparta Süleyman Demirel Üniversitesi,Endodonti AD. Danışman:Prof. Dr. Ayşe Diljin Keçeci 2016.
  • Taç, G. Tip II diyabetin farklı tanılara sahip dişlerde endodontik mikrofloraya etkisinin incelenmesi. Doktora Tezi, Isparta Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü 2008, Endodonti AD, Danışman:Prof. Dr. Ayşe Diljin Keçeci.
  • Marotta PS, Fontes TV, Armada L et al. Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population. J Endod. 2012; 38(3): 297-300.
  • Fouad AF, Burleson J. The effect of diabetes mellitus on endodontic treatment outcome: data from an electronic patient record. J Am Dent Assoc. 2003; 134(1): 43-51.
  • Britto LR, Katz J, Guelmann M et al. Periradicular radiographic assessment in diabetic and control individuals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 96(4): 449-52.
  • Tibúrcio-Machado CD, Bello MC, Maier J et al. Influence of diabetes in the development of apical periodontitis: a critical literature review of human studies. J Endod. 2017; 43(3): 370-6.
  • Segura-Egea JJ, Martín-González J, Cabanillas-Balsera D et al. Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis. Clin Oral Investig. 2016; 20(6): 1133-41.
  • Arya S, Duhan J, Tewari S et al. Healing of apical periodontitis after nonsurgical treatment in patients with type 2 diabetes. J Endod 2017; 43: 1623–7.
  • Schulze A, Schönauer M, Busse M. Sudden improvement of insulin sensitivity related to an endodontic treatment. J Periodontol 2007; 78.12: 2380-2384.
  • Maat MP, Kluft C. Determinants of C-reactive protein concentration in blood. Italian Heart Journal 2001; 2: 189–95.
  • Segura-Egea JJ, Jimenez-Moreno E, Calvo-Monroy C et al. Hypertension and dental periapical condition. J Endod. 2010; 36(11): 1800-4.
  • Pasqualini D, Bergandi L, Palumbo L et al. Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults. J Endod. 2012; 38(12): 1570-7.
  • Cosme-Silva, Leopoldo, et al. Hypertension affects the biocompatibility and biomineralization of MTA, High-plasticity MTA, and Biodentine. Braz Oral Res 2019; 33.
  • Abdolsamadi HR, Vahedi M, Esmaelli F et al. Serum interleukin-6 as a serologic marker of chronic periapical lesions: a case-control study. J Dent Res, Dental Clinics, Dental Prospects 2008; 2: 43–7.
  • Proctor ME, Turner DW, Kaminski EJ et al. Determination and relationship of C-reactive protein in human dental pulps and in serum. J Endod 1991; 17: 265–270.
  • Márton I, Kiss C, Balla G et al. Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. Oral Microbiol Immunol, 1988; 3.2: 95-96.
  • Ren, Yan-Fang; Malmstrom, Hans S. Rapid quantitative determination of C-reactive protein at chair side in dental emergency patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104.1: 49-55. Vidal F, Fontes TV, Marques TV et al. Association between apical periodontitis lesions and plasmatic levels of C‐reactive protein, interleukin 6 and fibrinogen in hypertensive patients Int Endod J. 2016: 49.12: 1107-1115.
  • Joshipura KJ, Wand HC, Merchant AT et al. Periodontal disease and biomarkers related to cardiovascular disease. J Dent Res. 2004; 83(2): 151-5.
  • Messing M, Souza LC, Cavalla F et al. Investigating Potential Correlations between Endodontic Pathology and Cardiovascular Diseases Using Epidemiological and Genetic Approaches. J Endod. 2019; 45.2: 104-110.
  • Ren H, Du M. Role of maternal periodontitis in preterm birth. Frontiers in Immunology 2017; 8:139.
  • Bain JL, Lester SR, Henry WD et al. Effects of induced periapical abscesses on rat pregnancy outcomes. Archives of Oral Biology 2009; 54: 162-71.
  • Ao M, Miyauchi M, Furusho H et al. Dental infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One 2015; 10: e0137249.
  • Tsosura TVS, Chiba FY, Mattera MSLC et al. Maternal apical periodontitis is associated with insulin resistance in adult offspring. Int Endod J 2019.
  • Alam Q, Alam MZ, Mushtaq G et al. Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines. Current Pharmaceutical Design 2016; 22: 541-8. Florencio-Silva R, Sasso GRS, Sasso-Cerri E et al. Effects of estrogen status in osteocyte autophagy and its relation to osteocyte viability in alveolar process of ovariectomized rats. Biomedicine & Pharmacotherapy 2018; 98: 406-415.
  • Romualdo PC, Lucisano MP, Paula-Silva FWG et al. Ovariectomy Exacerbates Apical Periodontitis in Rats with an Increase in Expression of Proinflammatory Cytokines and Matrix Metalloproteinases. J Endod 2018; 44: 780-5.
  • Malmström M. Immunoglobulin classes IgG, IgM, IgA and complement component C3 in dental periapical lesions of patients with rheumatoid disease. Scand J Rheumatol 1975; 4: 57–64.
  • Jalali P, Hasselgren G. Endodontic inter-appointment flare-ups: An example of chaos? Dent Hypotheses 2015; 6: 44–8.
  • Elkins DA, Torabinejad M, Schmidt RE et al. Polymerase chain reaction detection of human immunodeficiency virus DNA in human periradicular lesions. J Endod 1994; 20.8: 386-388.
  • Gerner NW, Hurlen B, Dobloug J et al. Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. Endod Dent Traumatol 1988; 4: 127–131.
  • Fontes TV; Marques FV, Gonçalves LS. Endodontic infection in HIV-infected individuals: An overview. Endodontic Practice Today, 2015; 9.1.
  • Ouies HS, Casamassimo OS, da Fonseca M. Sickle cell anemia: a review for the pediatric dentist. Pediatr Dent 2007; 29: 159–69.
  • Hebbel RP, Vercellotti GM, Nath KA. A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxis. Cardiovasc Hematol Disord Drug Targets 2009; 9: 271–92.
  • Al-Jafar H, Dashti H, Al-Haddad SJ et al. Dental alterations in sickle cell disease. J Dent Oral Care Med 2016; 2: 203.
  • Vgontzas A, Charleston IVL, Robbins MS. Headache and facial pain in sickle cell disease. Curr Pain Headache Rep 2016; 20: 1–10.
  • Costa CPS, Thomaz EBA, Souza SFC. Association between sickle cell anemia and pulp necrosis. J Endod 2013; 39: 177–81.
  • Movahhedian N, Haghnegahdar A, Owji F. How the prevalence of pulp stone in a population predicts the risk for kidney stone. Iran Endod J 2018; 13: 246–50.
  • Gabardo MCL, Wambier LM, Rocha JS et al. Association between Pulp Stones and Kidney Stones: A Systematic Review and Meta-analysis. J Endod. 2019 Sep;45(9):1099-1105.
Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derlemeler
Yazarlar

Jülide Ocak 0000-0002-6584-2669

Ayşe Diljin Keçeci 0000-0003-4738-6521

Yayımlanma Tarihi 20 Ağustos 2021
Gönderilme Tarihi 24 Mart 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

Vancouver Ocak J, Keçeci AD. Endodontik Tıp: Sistemik Hastalıkların Pulpal ve Periapikal Dokular ile İlişkisi. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2021;12(2):250-6.

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