Eritrosit Dağılım Genişliği ile Sabah Kan Basıncı Dalgalanması Arasındaki İlişki

Abstract

Amaç : Eritrosit dağılım genişliği (EDG), kalp yetmezliği, koroner arter hastalığı ve akut miyokard enfarktüsü olan hastalarda olumsuz sonuçlarla ilişkilidir. Sabah kan basıncı dalgalanması (SKBD) fenomeni, sabahları kan basıncında (KB) belirgin bir artış olarak tanımlanır. Bu çalışmada, EDG ve SKBD arasındaki ilişkiyi araştırmayı amaçladık.
Materyal ve Metod: Haziran 2019-Aralık 2019 tarihleri arasında ambulatuvar KB kaydı yapılan iki yüz seksen dokuz (289) hastanın verileri retrospektif olarak analiz edildi. Ambulatuar KB verileri ile SKBD hesaplanarak EDG ile ilişkisi araştırıldı.
Bulgular: Eritrosit dağılım genişliği üst değerine göre (%16) SKBD değerleri karşılaştırıldı (sırasıyla %16'nın üzerinde ve %16'nın altında, (33.7±16.2; 28.1±11.5; p = 0.038*) her iki grup arasında istatistiksel olarak anlamlı bir fark mevcuttu. SKBD ile ilişkili parametreleri göstermek için yapılan çok değişkenli linear regresyon analizinde SKBD’nin EDG (p=0.03) ve ürik asit (p= 0.02) ile ilişkili olduğu bulundu.
Sonuç: Çalışmamızda SKBD'nin EDG ile bağımsız olarak ilişkili olduğunu ve EDG %16'nın üzerinde olduğunda anlamlı olarak daha yüksek olduğunu gösterilmiştir. Yeni bir kardiyovasküler risk faktörü olan SKBD, olumsuz kardiyovasküler sonuçlarla bağlantılı olan EDG ile ilişkilidir. EDG’nin yüksek olması daha yüksek SKBD’yi gösterebilir. Ambulatuar KB değerlendirmelerinde sıklıkla ihmal ettiğimiz SKBD bir risk faktörü olarak değerlendirilmelidir ve tedavi konusunda hedef olup olmaması konusunda prospektif çalışmalara ihtiyaç vardır. 

Keywords

• Sabah kan basıncı dalgalanması
• eritrosit dağılım genişliği
• olumsuz kardiyak sonuçlar

The Relationship with Red Cell Distribution Width and Morning Blood Pressure Surge

Abstract

Objective: Red cell distribution width (RDW) is related to adverse outcomes in patients with heart failure, coronary artery disease and acute myocardial infarction. Morning Blood Pressure Surge (MBPS) phenomenon is defined as a prominent increase at BP in the morning. In this study, we aimed to investigate the relationship between these two cardiovascular risk factors, RDW and MBPS.
Material and Method: The two hundred eighty-nine (289) patient’s data who underwent ambulatory blood pressure recording, between June 2019-December 2019 was analysed retrospectively.
Results: Red cell distribution width upper limit is accepted as 16% in our hospital's biochemistry laboratory. When MBPS values were compared according to RDW cut-off values (respectively above 16% and 16%below), a statistically significant difference was revealed between both groups (33.7±16.2 vs 28.1±11.5; p= 0.038*). Multivariate linear regression analysis conducted for demonstrating associated parameters with MBPS and MBPS was found to be associated with RDW (p=0.03), and uric acid (P=0.02).
Conclusion: Our results showed that MBPS was independently associated with RDW and was significantly higher, when RDW was above 16%. MBPS, a new cardiovascular risk factor, is associated with RDW, which has been linked to adverse cardiovascular outcomes. MBPS, which we often neglect in ambulatory blood pressure evaluations, should be considered as a risk factor and prospective studies are needed to determine whether it is a target for treatment.

Keywords

• Morning blood pressure surge
• red cell distribution width
• adverse cardiac outcomes

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