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Year 2016, Volume 7, Issue 3, 24 - 30, 03.01.2017

Abstract

The effect of the overweight on the circulating cytokines and adipokines

Year 2016, Volume 7, Issue 3, 24 - 30, 03.01.2017

Abstract

Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine’ and adipokine’ levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (P <0.01). The IL-6 level was significantly higher in the OP group than in the NP group (P < 0.01). The adiponectin level was significantly higher in the NH group than in the OH and OP groups (P < 0.01). Leptin and resistin levels didn’t differ significantly among the groups (P > 0.01). Conclusions: The overweight status affected the cytokine’ and adipokine’ level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups.

Details

Journal Section Araştırma Articlesi
Authors

Zuhal Yetkin Ay>

0000-0003-4716-9404


Fethiye Çağlar Özşahin>


Duygu Kumbul Doğuç>


Birsen Harun Dağdeviren This is me


Ersin Uskun>

0000-0001-6446-0186


Fatma Yeşim Kırzıoğlu This is me

Publication Date January 3, 2017
Application Date May 26, 2016
Acceptance Date
Published in Issue Year 2016, Volume 7, Issue 3

Cite

Vancouver Yetkin Ay Z. , Çağlar Özşahin F. , Kumbul Doğuç D. , Harun Dağdeviren B. , Uskun E. , Kırzıoğlu F. Y. The effect of the overweight on the circulating cytokines and adipokines. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2017; 7(3): 24-30.

SDÜ Sağlık Bilimleri Dergisi, makalenin gönderilmesi ve yayınlanması dahil olmak üzere hiçbir aşamada herhangi bir ücret talep etmemektedir. Dergimiz, bilimsel araştırmaları okuyucuya ücretsiz sunmanın bilginin küresel paylaşımını artıracağı ilkesini benimseyerek, içeriğine anında açık erişim sağlamaktadır.