Effect of Gestational Diabetes Mellitus on Corneal Biomechanical Characteristics

Yıl 2020, Cilt: 11 Sayı: 1, 33 - 36, 03.03.2020

Seyfullah Kan , Uğur Acar , Adnan Karaibrahimoğlu , Merve İnanç Muhammed Kızılgül , Selvihan Beysel , Erman Çakal

Öz

Objective: This study aimed to investigate whether gestational
diabetes mellitus (GDM) affects the corneal biomechanical parameters.

Material-Method: Thirty-eight pregnant women, newly diagnosed with GDM
and, age- and gestational age-matched 34 healthy pregnant females were enrolled
in the study. The right eye of the participants was examined. The corneal
parameters including corneal hysteresis (CH), corneal resistance factor (CRF),
Goldmann-correlated intraocular pressure (IOPg), and the corneal compensated
IOP (IOPcc), obtained by The Ocular Response Analyzer (ORA) device were
compared statistically.

Results: The mean and gestational age of the participants was 30.71  ±5.09 years, 
25.95  ±1.56 weeks and 29.97  ±4.10 years, 25.76  ±1.30 weeks in pregnant females with GDM and
healthy pregnant females, respectively. No significant differences in age
(p=0.502) or gestational age (p=0.594) were noted. The values of CH, CRF, IOPg,
and IOPcc were determined to be higher in pregnant females with GDM as compared
to that in healthy pregnant females. However, there was no statistically
significant difference in any other parameter (p=0.183, p=0.303, p=0.732 and
p=0.330, respectively).

Conclusions: Short-term hyperglycemia does not affect the corneal
biomechanical parameters.

Anahtar Kelimeler

gestational diabetes mellitus, corneal biomechanics

Kaynakça

• 1- Shih KC, Lam KS, Tong L. A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 2017;7 (3):e251.
• 2- Misra SL, Braatvedt GD, Patel DV. Impact of diabetes mellitus on the ocular surface: a review. Clin Exp Ophthalmol. 2016;44 (4):278–88.
• 3- Rehany U, Ishii Y, Lahav M, Rumelt S. Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study. Cornea. 2000;19 (4):534–8.
• 4- Stitt AW. The maillard reaction in eye diseases. Ann N Y Acad Sci. 2005;1043:582–97.
• 5- Kaji Y, Usui T, Oshika T, Matsubara M, Yamashita H, Araie M, et al. Advanced glycation end products in diabetic corneas. Invest Ophthalmol Vis Sci. 2000;41 (2):362–8.
• 6- Sady C, Khosrof S, Nagaraj R. Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun. 1995;214 (3):793–7.
• 7- Hager A, Wegscheider K, Wiegand W. Changes of extracellular matrix of the cornea in diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 2009;247 (10):1369–74.
• 8- Ramm L, Herber R, Spoerl E, Pillunat LE, Terai N. Measurement of corneal biomechanical properties in diabetes mellitus using the Ocular Response Analyzer and the Corvis ST. Cornea. 2019; 38 (5):595–9.
• 9- Pérez-Rico C, Gutiérrez-Ortíz C, González-Mesa A, Zandueta AM, Moreno-Salgueiro A, Germain F. Effect of diabetes mellitus on Corvis ST measurement process. Acta Ophthalmol. 2015;93 (3):e193–8.
• 10- Scheler A, Spoerl E, Boehm AG. Effect of diabetes mellitus on corneal biomechanics and measurement of intraocular pressure. Acta Ophthalmol. 2012;90 (6):e447–51.
• 11- Kotecha A, Oddone F, Sinapis C, Elsheikh A, Sinapis D, Sinapis A, Garway-Heath DF. Corneal biomechanical characteristics in patients with diabetes mellitus. J Cataract Refract Surg. 2010;36 (11):1822–8.
• 12- Bekmez S, Kocaturk T. Higher Intraocular pressure levels associated with lower hysteresis in type 2 diabetes. Open Ophthalmol J. 2018;12:29–33.
• 13- Yazgan S, Celik U, Kaldırım H, Ayar O, Elbay A, Aykut V, et al. Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients. Clin Ophthalmol. 2014;8:1549–53.
• 14- Sahin A, Bayer A, Ozge G, Mumcuoğlu T. Corneal biomechanical changes in diabetes mellitus and their influence on intraocular pressure measurements. Invest Ophthalmol Vis Sci. 2009;50 (10):4597–604.
• 15- Goldich Y, Barkana Y, Gerber Y, Rasko A, Morad Y, Harstein M, et al. Effect of diabetes mellitus on biomechanical parameters of the cornea. J Cataract Refract Surg. 2009;35 (4):715–9.
• 16- Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005;31 (1):156–62.
• 17- Kotecha A. What biomechanical properties of the cornea are relevant for the clinician? Surv Ophthalmol. 2007;52 Suppl 2:S109–14.
• 18- Metzger BE, Buchanan TA, Coustan DR, de Leiva A, Dunger DB, Hadden DR, et al. Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care. 2007;30 Suppl 2:S251–60.
• 19- International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33 (3):676–82.
• 20- Bao F, Deng M, Zheng X, Li L, Zhao Y, Cao S, et al. Effects of diabetes mellitus on biomechanical properties of the rabbit cornea. Exp Eye Res. 2017;161:82–8.
• 21- Tabibian D, de Tejada BM, Gatzioufas Z, Kling S, Meiss VS, Boldi MO, et al. Pregnancy-induced changes in corneal biomechanics and topography are thyroid hormone related. Am J Ophthalmol. 2017;184:129–36.
• 22- Santiagu F, Bakhtiari A, Iqbal T, Khaliddin N, Lansingh VC, Subrayan V. Diabetes and pachymetry changes in pregnancy. Int Ophthalmol. 2018;38 (5):2069–76.
• 23- Naderan M, Jahanrad A. Anterior, posterior and biomechanical parameters of cornea during pregnancy in healthy eyes: a cohort study. Br J Ophthalmol. 2018;102 (3):309–12.
• 24- Sen E, Onaran Y, Nalcacioglu-Yuksekkaya P, Elgin U, Ozturk F. Corneal biomechanical parameters during pregnancy. Eur J Ophthalmol. 2014;24 (3):314–9.