Can Smaller Needle Size In Prostate Biopsy Reduce Complications Without Affecting Sample Quality And Cancer Detection Rates?

Year 2020, Volume: 11 Issue: 2, 242 - 247, 15.06.2020

Ercan Baş

Abstract

Purpose:
The aim of this study is to compare the 18G and 20G biopsy needle in
transrectal ultrasound guided prostate biopsy (TRUS-PBx) for diagnosis of
prostate cancer in terms of sample quality, cancer detection rates, pain and
other complications.

Material
and Method: 120 patients with PSA (prostate specific
antigen) values ​​of 2.5-10 ng/ml, prostate volumes of 30-80 cc and ages of
50-70 were randomly divided into two groups. However, the arm of the study
performed with 20G needle biopsy was stopped due to the very low cancer
detection rate when the number of patients reached 32. All patients in Group 2
were rebiopsied with an 18G needle 3 months later. In all patients,
complications and cancer detection rates were evaluated in during and after the
procedure.

Results:
The cancer detection rates in group 2 were significantly lower compared to
group 1. The VAS 2 score was lower in group 2 (p=0.008), but there was no
statistically significant difference in other VAS scores. In both groups, the
rate of side effects and complications related to biopsy were similar. All
patients in Group 2 were rebiopsied with an 18G needle. The rate of cancer
detection was significantly higher in patients who underwent TRUS-PBx with 18G
needle (p=0.0055).

Conclusion:
We found that the rate of obtaining sufficient sample for TRUS-PBx and
detection of cancer was very low in 20G compared to 18G needle. 20G needle had no superiority to 18G
needle in all complications, including pain. We concluded that 20-gauge needle
prostate biopsy was not an accurate approach in our study

Keywords

Prostate Biopsy, Needle Size, Sample Quality, Cancer Detection Rate, Complications

Can Smaller Needle Size in Prostate Biopsy Reduce Complications Without Affecting Sample Quality and Cancer Detection Rates?

Abstract

Amaç:
Çalışmanın amacı; Prostat kanseri tanısı için yapılan transrektal ultrason
eşliğinde prostat biyopsisinde (TRUS-PBx) standart olarak kullanılan 18G(gauge)
biyopsi iğnesi ile 20G biyopsi iğnesini alınan örnek kalitesi, kanser tespit
oranları, ağrı ve diğer komplikasyonlar açısından karşılaştırmaktır.

Materyal ve Metot: PSA
(prostate specific antigen) değerleri 2,5-10 ng/ml, prostat hacimleri 30-80 cc,
yaşları 50-70 arasında olan 120 hasta, 
sayıları eşit olacak şekilde rastgele iki gruba ayrıldı. Fakat 20G iğne
biyopsisi ile yapılan çalışmanın kolu, hasta sayısı 32’ye ulaştığında çok düşük
kanser tespit oranı nedeniyle durduruldu. Grup 2'deki tüm hastalara 3 ay sonra
18G iğnesi ile yeniden biyopsi yapıldı. Tüm hastalarda, işlemi sırasında ve
sonrasında ki komplikasyonlar ile kanser tespit oranları değerlendirildi.

Bulgular: Grup
2’dekilerde kanser tespit oranları grup 1’e kıyasla anlamlı derecede düşüktü.
VAS 2 skoru grup 2’de daha düşüktü (p=0,008) fakat diğer VAS skorlarında istatistiksel
olarak anlamlı fark yoktu. Her iki grupta biyopsiye bağlı yan etki ve
komplikasyon görülme oranı benzerdi. Grup 2’deki tüm hastalara 18G iğne ile
tekrar biyopsi yapıldı. Kanser tespit oranı 18G iğne ile TRUS-PBx yapılanlarda
istatistiksel olarak anlamlı derecede yüksekti (p=0,0055).

Sonuç: TRUS-PBx için
yeterli numune elde etme ve kanser saptama oranını, 18G iğneye kıyasla 20G
iğnede çok düşük olduğu bulundu. Ağrı dahil tüm komplikasyonlarda ise her iki
iğnenin klinik olarak bir birlerine karşı hiçbir üstünlüğü bulunamadı.
Çalışmamıza göre 20G iğne ile prostat biyopsisi almanın doğru bir yaklaşım
olmadığı sonucuna varıldı. 

Keywords

Prostat Biyopsisi, İğne Boyutu, Örnek Kalitesi, Kanser Tespit Oranı, Komplikasyonlar

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