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Gömülü 20 Yaş Dişi Cerrahisinden Sonra Uygulanan Düşük Doz Lazer ve Konsantre Büyüme Faktörünün Ağrı, Ödem, Trismus ve Yara İyileşmesi Üzerine Etkinliğinin Retrospektif Olarak Değerlendirilmesi

Year 2024, Volume: 15 Issue: 2, 185 - 197, 28.08.2024
https://doi.org/10.22312/sdusbed.1477893

Abstract

Gömülü 20 yaş dişi cerrahisinden sonra postoperatif olarak hastaların hayat kalitesini düşüren ağrı, ödem, trismus gibi komplikasyonlar görülmektedir. Yapılan çalışmalarla çekim soketine uygulanan kan konsantrasyonlarının ve düşük doz lazer (DDL) uygulamalarının olumlu etkileri gösterilmiştir. Bu çalışmanın amacı gömülü 20 yaş dişlerinin çekiminden sonra uygulanan DDL ve konsantre büyüme faktörü (KBF) uygulamalarının ağrı, ödem, trismus ve yara iyileşmesi üzerine olan etkinliğinin karşılaştırılmasıdır.

Çalışmamızda; Süleyman Demirel Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı’na 2022 Ocak- 2023 Ocak tarihleri arasında başvuran, gömülü 20 yaş dişleri çekiminden sonra DDL ve KBF uygulanan, sağlıklı 34 hastanın kayıtları incelenmiştir. Ağrının değerlendirilmesi için postoperatif 2. ve 7. günlerde VAS ölçeği kullanılmıştır. Ödemin değerlendirilmesi amacıyla preoperatif ve postoperatif 2. ve postoperatif 7. günlerde tüm hastalarda; tragus-ağız köşesi, tragus-pogonion ve lateral göz köşesi-angulus mandibula arası mesafelerin ölçümü esnek bir cetvel yardımı ile yapılmıştır. Trismus ölçümü için preoperatif ve postoperatif 2. ve postoperatif 7. gün ölçülen santral dişler arasındaki maksimum açıklığa bakılmıştır. Yara iyileşmesinin değerlendirilmesi postoperatif 2. ve 7. günde Landry yara iyileşmesi indeksi ile yapılmıştır. Sonuçlar istatistiksel olarak değerlendirilmiştir.

Çalışmamızda DDL ve KBF uygulamalarının ağrı, ödem ve yara iyileşmesi üzerine olan etkinlikleri istatistiksel olarak değerlendirildiğinde anlamlı bir fark bulunamamıştır. Trismus üzerine etkinliğine bakıldığında sadece 7. günde KBF’ nin trismus üzerindeki etkisi, DDL uygulamasına göre anlamlı düzeyde yüksek bulunmuştur.
DDL ve KBF uygulamasının ucuz, kolay uygulanabilir yöntemler olması nedeniyle klinik kullanımda önerilebileceği düşünülmüştür.

Ethical Statement

Bu çalışmada, “Yükseköğretim Kurumları Bilimsel Araştırma ve Yayın Etiği Yönergesi” kapsamında uyulması gerekli tüm kurallara uyulduğunu, bahsi geçen yönergenin “Bilimsel Araştırma ve Yayın Etiğine Aykırı Eylemler” başlığı altında belirtilen eylemlerden hiçbirinin gerçekleştirilmediğini taahhüt ederiz.

References

  • [1] Peñarrocha-Diago M, Camps-Font O, Sánchez-Torres A, Figueiredo R, Sánchez-Garcés MA, Gay-Escoda C. 2021. Indications of the extraction of symptomatic impacted third molars. A systematic review. J Clin Exp Dent, 13(3):e278.
  • [2] Ghaeminia H, Perry J, Nienhuijs MEL, Toedtling V, Tummers M, Hoppenreijs TJM, et al. 2016. Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. Cochrane Database of Systematic Reviews, 31:(8):CD003879.
  • [3] Synan W, Stein K. 2020. Management of Impacted Third Molars. Oral Maxillofac Surg Clin North Am, 32(4):519–59.
  • [4] Elayah SA, Liang X, Sakran KA, Xie L, Younis H, Alajami AE, et al. 2022. Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study. BMC Oral Health, 22(1):1–8.
  • [5] Sreesha S, Ummar M, Sooraj S, Aslam S, Roshni A, Jabir K. 2020. Postoperative pain, edema and trismus following third molar surgery – A comparitive study between submucosal and intravenous dexamethasone. J Family Med Prim Care, 9(5):2454.
  • [6] Srinivasan S, Avadhani NG. 2012. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med; 53(6): 1252-63.
  • [7] Huang YY, Chen ACH, Carroll JD, Hamblin MR. 2009. Biphasic dose response in low level lightherapy. Dose-Response, 7(4):358–83.
  • [8] Souza NHC, Ferrari RAM, Silva DFT, Nunes FD, Bussadori SK, Fernandes KPS. 2014. Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages. Braz J Phys Ther, 18(4):308–14.
  • [9] Mozzati M, Tumedei M, Gallesio G, Menicucci G, Manzella C, Testori T, et al. 2022. Healing of Alveolar Sockets Treated with Concentrated Growth Factors: A Split-Mouth Study. Materials 2022, 15(14):4859.
  • [10] Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scarì G, et al. 2011. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech, 74(8):772–7.
  • [11] Tukaram Kshirsagar J. 2017. Innovation in regeneration-Concentrated growth factor. INT J APPL DENT SCI, 3(2):206–8.
  • [12] Ramos, E. U., Benetti, L. P., Oliveira, J. C. S., & Bassi, A. P. F. 2022. Single-Dose Ibuprofen-Arginine as a Preventive for Pain, Edema, and Trismus After Impacted Lower Third Molar Surgery: A Randomized Split-Mouth Clinical Trial. Eur J Dent, 16(2), 396–402.
  • [13] Binti Zaaba, N. A. A., Rajasekar, A., & Kk, S. S. 2021. Evaluation of healing following frenectomy. Bioinformation, 17(12), 1138–43.
  • [14] Akbulut N, Akbulut S, Üstüner E, Demiralp KÖ, Çölok G. 2015. Gömülü Yirmiyaş Dişi Cerrahisi Sonrası Fasiyal Şişlik Üzerine NSAİ İlaçların Etkilerinin Subjektif ve Objektif Yöntemlerle Değerlendirilmesi. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, 7(3):169–79.
  • [15] Vallecillo C, Vallecillo-Rivas M, Gálvez R, Vallecıllo-Capilla M, Olmedo-Gaya Mv. 2021. Analgesic Efficacy Of Tramadol/Dexketoprofen Vs Ibuprofen After Impacted Lower Third Molar Extraction: A Randomized Controlled Clinical Trıal. Journal Of Evidence Based Dental Practice, 21(4):101618.
  • [16] López-Ramírez M, Vílchez-Pérez MÁ, Gargallo-Albiol J, Arnabat-Domínguez J, Gay-Escoda C. 2012. Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study. Lasers Med Sci, 27(3):559–66.
  • [17] Borges MMF, Malta CEN, Carlos ACAM, Crispim AA, de Moura JFB, Rebouças LM, et al. 2023. Photobiomodulation therapy in the treatment of radiotherapy-related trismus of the head and neck. Lasers Med Sci, 38(1):1–13.
  • [18] Isolan CP, Kinalski M de A, Leão OA de A, Post LK, Isolan TMP, Santos MBF dos. 2021. Photobiomodulation therapy reduces postoperative pain after third molar extractions: A randomized clinical trial. Med Oral Patol Oral Cir Bucal, 26(3):e341
  • [19] Hadad H, Santos AFP, de Jesus LK, Poli PP, Mariano RC, Theodoro LH, et al. 2022. Photobiomodulation Therapy Improves Postoperative Pain and Edema in Third Molar Surgeries: A Randomized, Comparative, Double-Blind, and Prospective Clinical Trial. J Oral Maxillofac Surg, 80(1):37.e1-37.e12.
  • [20] Eroglu CN, Keskin Tunc S. 2016. Effectiveness of Single Session of Low-Level Laser Therapy with a 940 nm Wavelength Diode Laser on Pain, Swelling, and Trismus After Impacted Third Molar Surgery, Photomed Laser Surg,34(9):406–10.
  • [21] Torul D, Omezli MM, Kahveci K. 2020. Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial. J Stomatol Oral Maxillofac Surg, 121(6):646–51.
  • [22] Özveri Koyuncu B, Işık G, Özden Yüce M, Günbay S, Günbay T. 2020. Effect of concentrated growth factor (CGF) on short-term clinical outcomes after partially impacted mandibular third molar surgery: A split-mouth randomized clinical study. J Stomatol Oral Maxillofac Surg, 121(2):118–23.
  • [23] Fang D, Li D, Li C, Yang W, Xiao F, Long Z. 2022. Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study. J Oral Maxillofac Surg, 80(4):700–8.
  • [24] Gümüşel G. Bilateral gömülü 3. molar cerrahisinde, konsantre büyüme faktörü (kbf) uygulamasının postoperatif ağrı ve ödem üzerine etkisinin araştırılması. Uzmanlık Tezi, Ege Üniversitesi; 2019.
  • [25] Yu T, Liu J, Yin J, Xu X, Yan S, Lan J. 2019. Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone. Hua Xi Kou Qiang Yi Xue Za Zhi, 37(4):398–402.
  • [26] Payer M, Jakse N, Pertl C, Truschnegg A, Lechner E, Eskici A. 2005. The clinical effect of LLLT in endodontic surgery: A prospective study on 72 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 100(3):375–9.
  • [27] Paschoal MAB, Santos-Pinto L. 2012. Therapeutic Effects of Low-Level Laser Therapy After Premolar Extraction in Adolescents: A Randomized Double-Blind Clinical Trial, Photomed Laser Surg, 30(9):559–64.
  • [28] Kohale B, Agrawal A, Raut C. 2018. Effect of low-level laser therapy on wound healing and patients’ response after scalpel gingivectomy: A randomized clinical split-mouth study. J Indian Soc Periodontol, 22(5):419.
  • [29] Ozcelik O, Cenk Haytac M, Kunin A, Seydaoglu G. 2008. Improved wound healing by low-level laser irradiation after gingivectomy operations: a controlled clinical pilot study. J Clin Periodontol, 35(3):250–4.
  • [30] Amato B, Farina MA, Campisi S, Ciliberti M, Di Donna V, Florio A, et al. 2019. CGF treatment of leg ulcers: A randomized controlled trial. Open Medicine (Poland), 14(1):959–67.
  • [31] Keranmu D, Ainiwaer A, Nuermuhanmode N, Ling W. 2021. Application of concentrated growth factor to autotransplantation with inflammation in recipient area. BMC Oral Health, 21(1):1–11.
  • [32] Chen YW, Lee CT, Hum L, Chuang SK. 2017. Effect of flap design on periodontal healing after impacted third molar extraction: a systematic review and meta-analysis. Int J Oral Maxillofac Surg, 46(3):363–72.
  • [33] Kamal A, Salman B, Razak NHA, Samsudin AR. 2020. A comparative clinical study between concentrated growth factor and low-level laser therapy in the management of dry socket. Eur J Dent, 14(4):613–20.

Retrospective Evaluation of the Effectiveness of Low Level Laser and Concentrated Growth Factor on Pain, Edema, Trismus and Wound Healing After Impacted Wisdom Tooth Surgery

Year 2024, Volume: 15 Issue: 2, 185 - 197, 28.08.2024
https://doi.org/10.22312/sdusbed.1477893

Abstract

Postoperative complications such as pain, edema and trismus are seen after impacted wisdom tooth surgery, which reduce the quality of life of patients. Studies have shown the positive effects of blood concentrations and low level laser applications applied to the extraction socket. The aim of this study was to investigate the effectiveness of low level laser and concentrated growth factor applications on pain, edema, trismus and wound healing after extraction of impacted wisdom teeth.

In our study, the records of 34 healthy patients who were admitted to the Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Suleyman Demirel University, between January 2022 and January 2023 and who underwent low level laser and CGF after extraction of impacted wisdom teeth were analyzed. The VAS scale was used to evaluate pain on postoperative days 2 and 7. for the evaluation of edema, the distances between the tragus and corner of the mouth, tragus and pogonion, and lateral eye corner and mandible were measured with a flexible ruler on preoperative, postoperative days 2 and 7, for trismus measurement, the maximum distance between the central teeth was measured preoperatively and on the 2nd and 7th postoperative days. Wound healing was evaluated with the Landry wound healing index on postoperative day 2 and 7. The results were evaluated statistically.

In our study, no significant difference was found when the effectiveness of low level laser and CGF applications on pain, edema and wound healing were evaluated statistically. Regarding the efficacy on trismus, only on the 7th day, the effect of CGF on trismus was found to be significantly better than low level laser application.
It is thought that DDL and KBF application can be recommended for clinical use because they are cheap and easily applicable methods.

References

  • [1] Peñarrocha-Diago M, Camps-Font O, Sánchez-Torres A, Figueiredo R, Sánchez-Garcés MA, Gay-Escoda C. 2021. Indications of the extraction of symptomatic impacted third molars. A systematic review. J Clin Exp Dent, 13(3):e278.
  • [2] Ghaeminia H, Perry J, Nienhuijs MEL, Toedtling V, Tummers M, Hoppenreijs TJM, et al. 2016. Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. Cochrane Database of Systematic Reviews, 31:(8):CD003879.
  • [3] Synan W, Stein K. 2020. Management of Impacted Third Molars. Oral Maxillofac Surg Clin North Am, 32(4):519–59.
  • [4] Elayah SA, Liang X, Sakran KA, Xie L, Younis H, Alajami AE, et al. 2022. Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study. BMC Oral Health, 22(1):1–8.
  • [5] Sreesha S, Ummar M, Sooraj S, Aslam S, Roshni A, Jabir K. 2020. Postoperative pain, edema and trismus following third molar surgery – A comparitive study between submucosal and intravenous dexamethasone. J Family Med Prim Care, 9(5):2454.
  • [6] Srinivasan S, Avadhani NG. 2012. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med; 53(6): 1252-63.
  • [7] Huang YY, Chen ACH, Carroll JD, Hamblin MR. 2009. Biphasic dose response in low level lightherapy. Dose-Response, 7(4):358–83.
  • [8] Souza NHC, Ferrari RAM, Silva DFT, Nunes FD, Bussadori SK, Fernandes KPS. 2014. Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages. Braz J Phys Ther, 18(4):308–14.
  • [9] Mozzati M, Tumedei M, Gallesio G, Menicucci G, Manzella C, Testori T, et al. 2022. Healing of Alveolar Sockets Treated with Concentrated Growth Factors: A Split-Mouth Study. Materials 2022, 15(14):4859.
  • [10] Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scarì G, et al. 2011. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech, 74(8):772–7.
  • [11] Tukaram Kshirsagar J. 2017. Innovation in regeneration-Concentrated growth factor. INT J APPL DENT SCI, 3(2):206–8.
  • [12] Ramos, E. U., Benetti, L. P., Oliveira, J. C. S., & Bassi, A. P. F. 2022. Single-Dose Ibuprofen-Arginine as a Preventive for Pain, Edema, and Trismus After Impacted Lower Third Molar Surgery: A Randomized Split-Mouth Clinical Trial. Eur J Dent, 16(2), 396–402.
  • [13] Binti Zaaba, N. A. A., Rajasekar, A., & Kk, S. S. 2021. Evaluation of healing following frenectomy. Bioinformation, 17(12), 1138–43.
  • [14] Akbulut N, Akbulut S, Üstüner E, Demiralp KÖ, Çölok G. 2015. Gömülü Yirmiyaş Dişi Cerrahisi Sonrası Fasiyal Şişlik Üzerine NSAİ İlaçların Etkilerinin Subjektif ve Objektif Yöntemlerle Değerlendirilmesi. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, 7(3):169–79.
  • [15] Vallecillo C, Vallecillo-Rivas M, Gálvez R, Vallecıllo-Capilla M, Olmedo-Gaya Mv. 2021. Analgesic Efficacy Of Tramadol/Dexketoprofen Vs Ibuprofen After Impacted Lower Third Molar Extraction: A Randomized Controlled Clinical Trıal. Journal Of Evidence Based Dental Practice, 21(4):101618.
  • [16] López-Ramírez M, Vílchez-Pérez MÁ, Gargallo-Albiol J, Arnabat-Domínguez J, Gay-Escoda C. 2012. Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study. Lasers Med Sci, 27(3):559–66.
  • [17] Borges MMF, Malta CEN, Carlos ACAM, Crispim AA, de Moura JFB, Rebouças LM, et al. 2023. Photobiomodulation therapy in the treatment of radiotherapy-related trismus of the head and neck. Lasers Med Sci, 38(1):1–13.
  • [18] Isolan CP, Kinalski M de A, Leão OA de A, Post LK, Isolan TMP, Santos MBF dos. 2021. Photobiomodulation therapy reduces postoperative pain after third molar extractions: A randomized clinical trial. Med Oral Patol Oral Cir Bucal, 26(3):e341
  • [19] Hadad H, Santos AFP, de Jesus LK, Poli PP, Mariano RC, Theodoro LH, et al. 2022. Photobiomodulation Therapy Improves Postoperative Pain and Edema in Third Molar Surgeries: A Randomized, Comparative, Double-Blind, and Prospective Clinical Trial. J Oral Maxillofac Surg, 80(1):37.e1-37.e12.
  • [20] Eroglu CN, Keskin Tunc S. 2016. Effectiveness of Single Session of Low-Level Laser Therapy with a 940 nm Wavelength Diode Laser on Pain, Swelling, and Trismus After Impacted Third Molar Surgery, Photomed Laser Surg,34(9):406–10.
  • [21] Torul D, Omezli MM, Kahveci K. 2020. Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial. J Stomatol Oral Maxillofac Surg, 121(6):646–51.
  • [22] Özveri Koyuncu B, Işık G, Özden Yüce M, Günbay S, Günbay T. 2020. Effect of concentrated growth factor (CGF) on short-term clinical outcomes after partially impacted mandibular third molar surgery: A split-mouth randomized clinical study. J Stomatol Oral Maxillofac Surg, 121(2):118–23.
  • [23] Fang D, Li D, Li C, Yang W, Xiao F, Long Z. 2022. Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study. J Oral Maxillofac Surg, 80(4):700–8.
  • [24] Gümüşel G. Bilateral gömülü 3. molar cerrahisinde, konsantre büyüme faktörü (kbf) uygulamasının postoperatif ağrı ve ödem üzerine etkisinin araştırılması. Uzmanlık Tezi, Ege Üniversitesi; 2019.
  • [25] Yu T, Liu J, Yin J, Xu X, Yan S, Lan J. 2019. Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone. Hua Xi Kou Qiang Yi Xue Za Zhi, 37(4):398–402.
  • [26] Payer M, Jakse N, Pertl C, Truschnegg A, Lechner E, Eskici A. 2005. The clinical effect of LLLT in endodontic surgery: A prospective study on 72 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 100(3):375–9.
  • [27] Paschoal MAB, Santos-Pinto L. 2012. Therapeutic Effects of Low-Level Laser Therapy After Premolar Extraction in Adolescents: A Randomized Double-Blind Clinical Trial, Photomed Laser Surg, 30(9):559–64.
  • [28] Kohale B, Agrawal A, Raut C. 2018. Effect of low-level laser therapy on wound healing and patients’ response after scalpel gingivectomy: A randomized clinical split-mouth study. J Indian Soc Periodontol, 22(5):419.
  • [29] Ozcelik O, Cenk Haytac M, Kunin A, Seydaoglu G. 2008. Improved wound healing by low-level laser irradiation after gingivectomy operations: a controlled clinical pilot study. J Clin Periodontol, 35(3):250–4.
  • [30] Amato B, Farina MA, Campisi S, Ciliberti M, Di Donna V, Florio A, et al. 2019. CGF treatment of leg ulcers: A randomized controlled trial. Open Medicine (Poland), 14(1):959–67.
  • [31] Keranmu D, Ainiwaer A, Nuermuhanmode N, Ling W. 2021. Application of concentrated growth factor to autotransplantation with inflammation in recipient area. BMC Oral Health, 21(1):1–11.
  • [32] Chen YW, Lee CT, Hum L, Chuang SK. 2017. Effect of flap design on periodontal healing after impacted third molar extraction: a systematic review and meta-analysis. Int J Oral Maxillofac Surg, 46(3):363–72.
  • [33] Kamal A, Salman B, Razak NHA, Samsudin AR. 2020. A comparative clinical study between concentrated growth factor and low-level laser therapy in the management of dry socket. Eur J Dent, 14(4):613–20.
There are 33 citations in total.

Details

Primary Language Turkish
Subjects Oral and Maxillofacial Surgery
Journal Section Araştırma Articlesi
Authors

Burak Mengütaş 0000-0001-5395-958X

Müge Çına 0000-0003-2005-3153

Publication Date August 28, 2024
Submission Date May 3, 2024
Acceptance Date June 6, 2024
Published in Issue Year 2024 Volume: 15 Issue: 2

Cite

Vancouver Mengütaş B, Çına M. Gömülü 20 Yaş Dişi Cerrahisinden Sonra Uygulanan Düşük Doz Lazer ve Konsantre Büyüme Faktörünün Ağrı, Ödem, Trismus ve Yara İyileşmesi Üzerine Etkinliğinin Retrospektif Olarak Değerlendirilmesi. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2024;15(2):185-97.

SDÜ Sağlık Bilimleri Dergisi, makalenin gönderilmesi ve yayınlanması dahil olmak üzere hiçbir aşamada herhangi bir ücret talep etmemektedir. Dergimiz, bilimsel araştırmaları okuyucuya ücretsiz sunmanın bilginin küresel paylaşımını artıracağı ilkesini benimseyerek, içeriğine anında açık erişim sağlamaktadır.