PERİODONTİTİS DERECESİ İLE DİŞETİ OLUĞU SIVISI TNF-α VE MIP-1α SEVİYELERİ ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ: ÖN ÇALIŞMA

Year 2022, , 243 - 248, 30.06.2022

Umut Yiğit , Fatih Karaaslan , Ahu Dikilitaş , Esra Özge Aydın

https://doi.org/10.17343/sdutfd.1034024

Abstract

Amaç
Periodontitisin patogenezindeki sitokin ve kemokinlerin
rolü,periodontitisin başlaması ve ilerlemesinde
önemli fonksiyonlara sahip olan ile Tümör Nekroz
Faktör alfa (TNF-α) ve Makrofaj İnflamatuar Protein
1α ile (MIP 1α) gösterilmiştir. Bununla birlikte, farklı
periodontitis derecelerinin sitokin ve kemokin profilleri
hala belirsizdir ve periodontitisin ilerleme hızı ile ilişkili
biyobelirteçler hakkında henüz kesin bilgiler bildirilmemiştir.
Bu nedenle, bu çalışmanın amacı Derece A,
B ve C'deki dişeti oluğu sıvısındaki (DOS) MIP-1α ve
TNF-α'nın düzeylerini tahmin etmek ve periodontitis
derecesini belirlemede güvenilir biyobelirteçler olarak
rollerini değerlendirmektir.
Gereç ve Yöntem
Bireyler periodontitis derecelerine göre Evre IV periodontitis
tanısı alan ve Derece A (Derece A, n = 21),
Evre IV periodontitis tanısı alan ve Derece B (Derece
B, n =21) ve Evre IV periodontitis tanısı alan Derece
C bireyler (Derece C, n = 21) olmak üzere üç gruba
ayrıldı.
Bulgular
Ortalama TNF-α seviyeleri açısından gruplar arasında
anlamlı bir fark olmamasına rağmen, Derece
C’deki ortalama MIP-1α seviyesi Derece B ve Derece
A'dan anlamlı derecede yüksekti. Derece B'deki ortalama
MIP-1α seviyesi Derece A'dan önemli ölçüde
daha yüksek (p < 0.05, Kruskal–Wallis testi) bulundu.
Sonuç: MIP-1α, periodontitis derecesi için tanımlayıcı
bir biyobelirteç olarak klinik kullanıma sahip olabilir.

Keywords

kemokin, sitokin, dişeti oluğu sıvısı ,, periodontitis

Supporting Institution

destekleyen kurum yok

Project Number

proje numarası yok

THE ASSOCIATION BETWEEN GRADE OF PERIODONTITIS AND GCF LEVELS OF TNF-α AND MIP-1α: A PRELIMINARY STUDY

Abstract

Objective
The role of cytokines and chemokines in the
pathogenesis of periodontitis indicates that tumor
necrosis factor alpha (TNF-α) and macrophage
inflammatory protein 1α (MIP1α) have crucial functions
in the initiation and progression of periodontitis.
However, the cytokine and chemokine profiles of
different grades of periodontitis are still unclear, and
no conclusive information has yet been reported
on biomarkers associated with the progression rate
of periodontitis. Thus, the aim of the present study
was to estimate the gingival crevicular fluid (GCF)
levels of MIP-1α and TNF-α in Grades A, B, and C
and to evaluate their role as reliable biomarkers in
determining the grade of periodontitis.
Materials and Methods
Individuals were divided into three groups according
to their grade of periodontitis: individuals diagnosed as
Stage IV periodontitis with Grade A (Grade A, n = 21),
individuals diagnosed as Stage IV periodontitis with
Grade B (Grade B, n = 21), and individuals diagnosed
as Stage IV periodontitis with Grade C (Grade C,
n = 21).
Results
Although there were no significant differences between
groups in terms of mean TNF-α levels, the mean MIP-
1α level of Grade C was significantly higher than that
of Grade B and Grade A. The mean MIP-1α level of
Grade B was significantly higher than that of Grade A
(p < 0.05, Kruskal–Wallis test).
Conclusion
MIP-1α could have clinical utility as a screening
biomarker for the grade of periodontitis.

Keywords

Chemokines, cytokines, gingival crevicular fluid, periodontitis

Project Number

proje numarası yok

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