GLİAL TÜMÖR TEDAVİSİNDE TAMAMLAYICI HEDEF TEDAVİ: PROSTAT SPESİFİK MEMBRAN ANTİJEN (PSMA)

Year 2022, , 133 - 137, 01.03.2022

Ali Serdar Oğuzoğlu , Nilgün Şenol , Hasan Yasan , Ramazan Oğuz Yüceer , Cengiz Gazeloğlu , İbrahim Metin Çiriş

https://doi.org/10.17343/sdutfd.1066328

Abstract

Amaç
Gliomalar farklı dereceleri ile en sık karşılaşılan primer
beyin tümörleridir. Özellikle yüksek dereceli olanlarda
tümör anjiogenezi hem ana komponenetlerden biri,
hem de prognoz açısından değerli bir belirleyicidir.
Bu çalışmada, farklı hedef tedavileri belirleyebilmek
için immunohistokimyasal metod ile glial tümörlerde
prostat spesifik membran antijeni (PSMA) salınımını
değerlendirmeyi amaçladık.
Gereç ve Yöntem
Derece II (n=22), Derece III (n=19) ve Derece IV
(n=52) glial tümörlü 93 hastadan alınan örneklerde
PSMA antikorları immunohistokimyasal metod ile incelendi.
Tümör dokusundaki PSMA boyanma yoğunluğu
ve tümör epitelleri incelendi. Tümör epitelinde
tümör ve tümör-dışı dokuda PSMA salınımına göre
vasküler salınım ve yoğunluk skoru analiz edildi.
Bulgular
Yüksek dereceli gliomalarda, vasküler PSMA boyanma
yüzdesi ve vasküler yoğunluk skoru düşük derecelilere
göre anlamlı olarak daha yüksek (p<0,005)
bulundu. Tümör epitelinde vasküler PSMA boyanma
yüzdesinde (p<0,05) düşük derecelilerde anlamlı bir
yükseklik (p<0,05) olmasına rağmen, yüksek derecelilerde
görülen vasküler yoğunluk yüzdesindeki yükseklik
anlamlı değildi.
Sonuç
Yüksek dereceli glial tümörlerde neovaskülarizasyonun
fazla olması ile PSMA ekspresyon yüzdesi ve
yoğunluğunun anlamlı şekilde yüksek bulunması bu
tümör grubunda PSMA’ne yönelik tedavi edici ajanların
etkili olabileceğini göstermektedir.

Keywords

glial tümör, prostat-spesifik membran, anjiogenez, antigen

Supporting Institution

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

TSG 2020-8134

Thanks

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PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) FOR A COMPLEMENTARY TARGET THERAPY IN GLIAL TUMORS

Abstract

Objective
Gliomas are the most common primary brain tumors
with different grades. Especially in the high grade gliomas
tumor angiogenesis is an essential component,
and a valuable marker for the prognosis. In this stuıdy
we aimed to evaluate the expression of prostate specific
membrane antigen (PSMA) in glial tumors by immunochemistry
method to determine different targeted
therapies.
Material and Methods
Overall 93 patients’ specimens, including Grade II
(n=22), Grade III (n=19), Grade IV (n=52) glial tumors,
were evaluated for PSMA-antibody via immunohistochemical
method. PSMA staining intensities in tumor
tissue and tumor epithelium were analyzed. Vascular
expression in tumoral and extratumoral stroma, and
intensity score, according to PSMA expression, in tumoral
epithelium were analyzed.
Results
In high grade gliomas, vascular PSMA staining percentage
and vascular intensity score were significantly
higher than low grade (p<0.05). In the epithelium of
the tumors, although a significant increase was observed
in vascular PSMA staining percentage (p<0.05)
of low grade tumors, the increase in vascular intensity
score of high grade tumors was not significant.
Conclusion
Significant increase in PSMA staining percentage and
vascular intensity score of tumor stroma in high grade
gliomas due to more neovascularisation, demonstrates
that therapeutic agents can be effective in this
group of tumors.

Keywords

glial tumor, prostate-spesific membrane, angiogenesis, antigen

Project Number

TSG 2020-8134

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