PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) FOR A COMPLEMENTARY TARGET THERAPY IN GLIAL TUMORS

Abstract

Objective Gliomas are the most common primary brain tumors with different grades. Especially in the high grade gliomas tumor angiogenesis is an essential component, and a valuable marker for the prognosis. In this stuıdy we aimed to evaluate the expression of prostate specific membrane antigen (PSMA) in glial tumors by immunochemistry method to determine different targeted therapies. Material and Methods Overall 93 patients’ specimens, including Grade II (n=22), Grade III (n=19), Grade IV (n=52) glial tumors, were evaluated for PSMA-antibody via immunohistochemical method. PSMA staining intensities in tumor tissue and tumor epithelium were analyzed. Vascular expression in tumoral and extratumoral stroma, and intensity score, according to PSMA expression, in tumoral epithelium were analyzed. Results In high grade gliomas, vascular PSMA staining percentage and vascular intensity score were significantly higher than low grade (p<0.05). In the epithelium of the tumors, although a significant increase was observed in vascular PSMA staining percentage (p<0.05) of low grade tumors, the increase in vascular intensity score of high grade tumors was not significant. Conclusion Significant increase in PSMA staining percentage and vascular intensity score of tumor stroma in high grade gliomas due to more neovascularisation, demonstrates that therapeutic agents can be effective in this group of tumors.

Keywords

• glial tumor
• prostate-spesific membrane
• angiogenesis
• antigen

GLİAL TÜMÖR TEDAVİSİNDE TAMAMLAYICI HEDEF TEDAVİ: PROSTAT SPESİFİK MEMBRAN ANTİJEN (PSMA)

Abstract

Amaç Gliomalar farklı dereceleri ile en sık karşılaşılan primer beyin tümörleridir. Özellikle yüksek dereceli olanlarda tümör anjiogenezi hem ana komponenetlerden biri, hem de prognoz açısından değerli bir belirleyicidir. Bu çalışmada, farklı hedef tedavileri belirleyebilmek için immunohistokimyasal metod ile glial tümörlerde prostat spesifik membran antijeni (PSMA) salınımını değerlendirmeyi amaçladık. Gereç ve Yöntem Derece II (n=22), Derece III (n=19) ve Derece IV (n=52) glial tümörlü 93 hastadan alınan örneklerde PSMA antikorları immunohistokimyasal metod ile incelendi. Tümör dokusundaki PSMA boyanma yoğunluğu ve tümör epitelleri incelendi. Tümör epitelinde tümör ve tümör-dışı dokuda PSMA salınımına göre vasküler salınım ve yoğunluk skoru analiz edildi. Bulgular Yüksek dereceli gliomalarda, vasküler PSMA boyanma yüzdesi ve vasküler yoğunluk skoru düşük derecelilere göre anlamlı olarak daha yüksek (p<0,005) bulundu. Tümör epitelinde vasküler PSMA boyanma yüzdesinde (p<0,05) düşük derecelilerde anlamlı bir yükseklik (p<0,05) olmasına rağmen, yüksek derecelilerde görülen vasküler yoğunluk yüzdesindeki yükseklik anlamlı değildi. Sonuç Yüksek dereceli glial tümörlerde neovaskülarizasyonun fazla olması ile PSMA ekspresyon yüzdesi ve yoğunluğunun anlamlı şekilde yüksek bulunması bu tümör grubunda PSMA’ne yönelik tedavi edici ajanların etkili olabileceğini göstermektedir.

Keywords

• glial tümör
• prostat-spesifik membran
• anjiogenez
• antigen

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