PAROTİS BEZİNİN HİGH GRADE ONKOSİTİK MUKOEPİDERMOİD KARSİNOMU, MAML2 TRANSLOKASYONU, NADİR BİR OLGU
Year 2023,
, 131 - 134, 14.03.2023
Ramazan Oğuz Yüceer
,
Mehmet Kıran
,
İbrahim Metin Çiriş
,
Yusuf Çağdaş Kumbul
,
Kayhan Başak
Abstract
Mukoepidermoid karsinom (MEK) tükürük bezinin en
sık görülen malign tümörüdür ve en sık parotiste görülür.
Onkositik mukoepidermoid karsinom (OMEK) nadir
subtiptir. Burada 28 yaşında endometrium kanseri
nedeniyle takip edilen kadın hastanın, sağ parotiste
izlenen kitlesinin primer tümör mü metastatik tümör
mü olduğunu histolojik, immünhistokimyasal ve moleküler
sonuçlarıyla sunmayı amaçladık.
References
- 1. Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis
G, Lagogiannis GA, et al. Mucoepidermoid carcinoma of the
salivary glands. Review of the literature and clinicopathological
analysis of 18 patients. Oral oncology. 2007;43(2):130-6.
- 2. El-Naggar AK GJ, Slootweg PJ, Chan JKC, Takata T WHO
Classification of Tumours of the Head and Neck. WHO/IARC
Classification of Tumours of the Head and Neck. , 4th edn
Lyon: IARC Presslow. 2017.
- 3. Qureshi, S., Janjua, O.S., & Janjua, S.M. (2012). Mucoepidermoid
carcinoma:A clinicopathological review of 75 cases. International
Journal of Oral and Maxillofacial Pathology, 3, 5-9.
- 4. Ellis GL AP. Atlas of Tumor Pathology. Tumors of the Salivary
Glands. Amer Registry of Pathology; 1st edition (January 1,
1992)
- 5. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas
AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid
Carcinoma: A Comparison of Histologic Grading Systems
and Relationship to MAML2 Rearrangement and Prognosis.
Am J Surg Pathol. 2019 Jul;43(7):885-897. doi: 10.1097/
PAS.0000000000001252. PMID: 31021855; PMCID:PMC6629427.
- 6. Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo
I, et al. Molecular classification of mucoepidermoid carcinomas-
prognostic significance of the MECT1-MAML2 fusion oncogene.
Genes, chromosomes & cancer. 2006;45(5):470-81.
- 7. León X, Szafranska J, Méndez JE. A case of necrotizing
sialometaplasia. Acta otorrinolaringologica espanola.
2020;71(5):328-9.
- 8. Tandon A, Jaiswal R, Siddiqui S, Bordoloi B. Keratinizing pleomorphic
adenoma: An unusual case report. Journal of oral and
maxillofacial pathology : JOMFP. 2018;22(Suppl 1):S69-s72.
- 9. Yorita K, Nakagawa H, Miyazaki K, Fukuda J, Ito S, Kosai M.
Infarcted Warthin tumor with mucoepidermoid carcinoma-like
metaplasia: a case report and review of the literature. Journal
of medical case reports. 2019;13(1):12.
- 10. Damjanov I, Skenderi F, Vranic S. Mammary Analogue Secretory
Carcinoma (MASC) of the salivary gland: A new tumor entity.
Bosnian journal of basic medical sciences. 2016;16(3):237-8.
- 11. Panchbhai AS. Primary squamous cell carcinoma of salivary
gland: Report of a rare case. Journal of cancer research and
therapeutics. 2015;11(3):664.
- 12. Birkeland AC, Foltin SK, Michmerhuizen NL, Hoesli RC, Rosko
AJ, Byrd S, et al. Correlation of Crtc1/3-Maml2 fusion status,
grade and survival in mucoepidermoid carcinoma. Oral oncology.
2017;68:5-8.
HIGH-GRADE ONCOCYTIC MUCOEPIDERMOID CARCINOMA OF PAROTID GLAND, MAML2 TRANSLOCATION, A RARE CASE
Year 2023,
, 131 - 134, 14.03.2023
Ramazan Oğuz Yüceer
,
Mehmet Kıran
,
İbrahim Metin Çiriş
,
Yusuf Çağdaş Kumbul
,
Kayhan Başak
Abstract
Mucoepidermoid carcinoma (MEC) is the most
common malignant tumor of the salivary gland and
is most commonly seen in the parotid. Oncocytic
mucoepidermoid carcinoma (OMEC) is a rare
subtype. Here, we aimed to present the histological,
immunohistochemical, and molecular results of a
28-year-old female patient followed for endometrial
cancer, whether the mass in the right parotid is a
primary or metastatic tumor.
References
- 1. Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis
G, Lagogiannis GA, et al. Mucoepidermoid carcinoma of the
salivary glands. Review of the literature and clinicopathological
analysis of 18 patients. Oral oncology. 2007;43(2):130-6.
- 2. El-Naggar AK GJ, Slootweg PJ, Chan JKC, Takata T WHO
Classification of Tumours of the Head and Neck. WHO/IARC
Classification of Tumours of the Head and Neck. , 4th edn
Lyon: IARC Presslow. 2017.
- 3. Qureshi, S., Janjua, O.S., & Janjua, S.M. (2012). Mucoepidermoid
carcinoma:A clinicopathological review of 75 cases. International
Journal of Oral and Maxillofacial Pathology, 3, 5-9.
- 4. Ellis GL AP. Atlas of Tumor Pathology. Tumors of the Salivary
Glands. Amer Registry of Pathology; 1st edition (January 1,
1992)
- 5. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas
AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid
Carcinoma: A Comparison of Histologic Grading Systems
and Relationship to MAML2 Rearrangement and Prognosis.
Am J Surg Pathol. 2019 Jul;43(7):885-897. doi: 10.1097/
PAS.0000000000001252. PMID: 31021855; PMCID:PMC6629427.
- 6. Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo
I, et al. Molecular classification of mucoepidermoid carcinomas-
prognostic significance of the MECT1-MAML2 fusion oncogene.
Genes, chromosomes & cancer. 2006;45(5):470-81.
- 7. León X, Szafranska J, Méndez JE. A case of necrotizing
sialometaplasia. Acta otorrinolaringologica espanola.
2020;71(5):328-9.
- 8. Tandon A, Jaiswal R, Siddiqui S, Bordoloi B. Keratinizing pleomorphic
adenoma: An unusual case report. Journal of oral and
maxillofacial pathology : JOMFP. 2018;22(Suppl 1):S69-s72.
- 9. Yorita K, Nakagawa H, Miyazaki K, Fukuda J, Ito S, Kosai M.
Infarcted Warthin tumor with mucoepidermoid carcinoma-like
metaplasia: a case report and review of the literature. Journal
of medical case reports. 2019;13(1):12.
- 10. Damjanov I, Skenderi F, Vranic S. Mammary Analogue Secretory
Carcinoma (MASC) of the salivary gland: A new tumor entity.
Bosnian journal of basic medical sciences. 2016;16(3):237-8.
- 11. Panchbhai AS. Primary squamous cell carcinoma of salivary
gland: Report of a rare case. Journal of cancer research and
therapeutics. 2015;11(3):664.
- 12. Birkeland AC, Foltin SK, Michmerhuizen NL, Hoesli RC, Rosko
AJ, Byrd S, et al. Correlation of Crtc1/3-Maml2 fusion status,
grade and survival in mucoepidermoid carcinoma. Oral oncology.
2017;68:5-8.