COULD GROWTH DIFFERENTIATION FACTOR-15 BE A NEW INFLAMMATORY PATHWAY IN PSORIASIS VULGARIS?

Abstract

Objective Psoriasis vulgaris is a chronic inflammatory disease, in which T cells play an important role in the etiopathogenesis and inflammatory mechanisms. Growth differentiation factor (GDF) 15 is a member of the transforming growth factor beta superfamily (TGF-ß), which increases with inflammation and has various cell regulatory functions. In this study; it was aimed to evaluate the relationship between serum GDF-15 level and tumor necrosis factor alpha (TNF-α), which is thought to have a role in the etiopathogenesis of the disease, and other metabolic parameters. Material and Method Forty-one patients with psoriasis vulgaris and 41 healthy controls were included in the study. Dermatological examination of all patients was performed and the psoriasis area severity index (PASI) score was calculated. Height and weight measurements, systolic and diastolic blood pressures, waist and hip circumferences, lipid profiles, and biochemical parameters of the patients were evaluated. Serum GDF-15 and TNF-α levels were measured by the ELISA method. Results There was no significant difference between the patient and control groups in terms of age, gender, lipid profiles, biochemical parameters and high-sensitivity C-reactive protein (hs-CRP) levels. Serum GDF-15 and TNF-α levels were found to be significantly higher in the patient group compared to the control group (p<0.001 and p=0.015). A positive correlation was found between GDF-15 and TNF-α levels (r=0.455, p=0.04). Conclusion We think that GDF-15 may have a role in psoriasis, especially in the inflammatory pathway associated with TNF-α.

Keywords

• Psoriasis
• inflamation
• GDF15
• comorbidity

BÜYÜME FARKLILAŞMA FAKTÖRÜ-15 PSORİASİS VULGARİSTE YENİ BİR İNFLAMATUVAR YOLAK OLABİLİR Mİ?

Abstract

Amaç Psoriasis vulgaris kronik inflamatuvar bir hastalık olup, etyopatogenezde T hücrelerin önemli rol oynadığı inflamatuvar mekanizmalar rol almaktadır. Son yıllarda psoriasisin sadece deriye sınırlı olmayıp aynı zamanda bazı komorbiditeler ile ilişkili olduğu gösterilmiştir. Büyüme farklılaşma faktörü-15 (GDF-15), dönüştürücü büyüme faktörü beta süper ailesinin (TGF-ß) bir üyesidir ve inflamasyonla artmaktadır. Bu çalışmada; serum GDF-15 düzeyi ve bunun hastalığın etyopatogenezinde rolü olduğu düşünülen tümör nekrozis faktör alfa (TNF-α) ve diğer metabolik parametrelerle arasındaki ilişkinin değerlendirilmesi amaçlandı. Gereç ve Yöntem Çalışmaya 41 psoriasis vulgarisli hasta ve 41 sağlıklı kontrol dahil edildi. Tüm katılımcıların dermatolojik muayenesi yapıldı ve psoriasis alan ve şiddet indeksi (PAŞİ) skoru hesaplandı. Tüm katılımcıların boy, kilo ölçümleri, sistolik ve diastolik kan basınçları, bel ve kalça çevreleri, lipit profilleri, biyokimyasal parametreleri değerlendirildi. Serum GDF-15 ve TNF-α düzeyleri ELİSA yöntemi ile ölçüldü. Bulgular Hasta ve kontrol grubu arasında yaş, cinsiyet, lipit profilleri, biyokimyasal parametreler ve yüksek-sensitif C-reaktif protein (hs-CRP) düzeyleri açısından anlamlı fark gözlenmedi. Hasta grubunda kontrol grubuna kıyasla serum GDF-15 ve TNF-α düzeyleri anlamlı derecede yüksek bulundu (p<0.001 ve p=0.015). GDF-15 ve TNF-α düzeyleri arasında pozitif korelasyon saptandı (r=0.455, p=0.04). Sonuç GDF-15’in psoriasiste özellikle TNF-α ile ilişkili inflamatuvar yolakta rolü olabileceğini düşünmekteyiz.

Keywords

• Psoriasis
• inflamasyon
• GDF15
• komorbidite

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