CAN PROSTATE-SPECIFIC MEMBRANE ANTIGENE TAKE PART IN MENENGIOMA TREATMENT?

Year 2023, , 302 - 307, 23.09.2023

Ali Serdar Oğuzoğlu , Nilgün Şenol , Hasan Yasan , Ramazan Oğuz Yüceer , İbrahim Metin Çiriş

https://doi.org/10.17343/sdutfd.1209482

Abstract

Objective
In tumor development, tumor angiogenesis is an
essential component, and a valuable marker in the
differantial diagnosis of brain tumors. As menengiomas
are highly vascular tumors in this study, we aimed
to evaluate the expression of prostate-spesific
membrane antigen (PSMA) in menengiomas by
immunohistochemistry method to determine different
target therapies.
Material and Method
Pathologic specimens with the diagnosis Grade I
(n=32), Grade II (n=6) ve Grade III (n=10) of 48 patients
operated for menengioma in our clinic, were evaluated
for PSMA-antibody via immunohistochemical method.
PSMA staining intensities in tumor tissue and tumor
epithelium were analyzed. Vascular expression in
tumoral and extratumoral stroma, and intensity score,
according to PSMA expression, in tumoral epithelium
were analyzed.
Results
Immunohistochemical analyses of different grade
menengioma specimens showed no statistically
significant differences between PSMA expression and
PSMA staining intensities in tumor tissue and tumor
epithelium (p>0.05).
Conclusion
Some molecular biomarkers, that take part in
angiogenesis of agressive and unresectable
menengiomas come into prominence. Although no
significant results were achieved in terms of PSMA, as
the molecular and genetic techniques progress, tumor
biology manifestation and determination of potential
targets will lead to new treatment procedures.

Keywords

menengioma, antigen, prostate-spesific membrane, angiogenesis

Project Number

TSG 2020-8134 numara

PROSTAT-SPESİFİK MEMBRAN ANTİGEN MENENGİOM TEDAVİSİNDE YER ALABİLİR Mİ?

Abstract

Amaç
Tümör oluşumunda ve ayırıcı tanısında tümör anjiogenezi
önemli bir unsur ve değerli bir göstergedir.
Menengiomlar vasküleritesi yüksek tümörler olması
nedeni ile bu çalışmada, farklı tedavi protokollerinin
geliştirilebilmesi açısından menengiomlarda immunohistokimyasal
yöntemlerle prostat-spesifik membran
antijen (PSMA) salınımının değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem
Kliniğimizde opere edilerek Derece I (n=32), Derece II
(n=6) ve Derece III (n=10) menengiom tanısı almış 48
hastadan alınmış olan doku örneklerinde PSMA antikorları
immunohistokimyasal metod ile incelendi. Tümör
dokusundaki PSMA boyanma yoğunluğu ve yüzdesi
incelendi. Tümör epitelinde tümör ve tümör-dışı
dokuda PSMA salınımına göre vasküler salınım ve
yoğunluk skoru analiz edildi.
Bulgular
Farklı derecelerdeki menengiom preparatlarında yapılan
immunohistokimyasal analizler tümör epitelinde
ve stromasında PSMA salınım ve yoğunluk skorları
arasında istatistiksel olarak anlamlı farklılık olmadığını
gösterdi (p>0.05).
Sonuç
Agresif seyreden, rezeke edilemeyen menegiomlarda
anjiogeneziste rol alan bazı moleküler biomarkerlar
önem kazanmaktadır. Her ne kadar PSMA açısından
anlamlı sonuçlar elde edilmemiş olsa da moleküler ve
genetik teknikler geliştikçe tümör biyolojisinin ortaya
konup potansiyel hedeflerin belirlenmesi yeni tedavi
yolları açacaktır.

Keywords

menengiom, antijen, prostat-spesifik membran, anjiogenez

Supporting Institution

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri

Project Number

TSG 2020-8134 numara

Thanks

-

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