FLUOKSETİN VE DÜŞÜK DOZ TRAZODONUN BİRLİKTE KULLANIMIYLA OLASI SEROTONİN SENDROMU DÜŞÜNDÜREN VE NARANJO İLAÇ YAN ETKİSİ OLASILIĞI ÖLÇEĞİ İLE DEĞERLENDİRİLEN BİR OLGU

Abstract

Serotonin sendromu serotonerjik ajan kullanımı sonrasında oluşan serotonin reseptörlerinin aşırı uyarılması sonucu gelişen nadir görülen fakat mortal seyredebilen sendromdur. Klinik belirti ve bulgular kognitif, nöromüsküler ve otonomik alanda görülmektedir. Serotonerjik etkili bir veya daha fazla ajanın birlikte kullanılması bu sendroma neden olur. Klinik görünümü hafif şiddette olup gözden kaçabilen olgular olduğu gibi hayatı tehdit eden, yoğun bakım ve mekanik ventilasyon gerektiren şiddette de olabilmektedir. Bu yazıda fluoksetin tedavisine trazodon eklenmesi ve doz artırılması sonrasında 24 saat içerisinde gelişen serotonin sendromu düşündüren bir vaka sunulmuştur.

Keywords

• Fluoksetin
• Serotonin sendromu
• Trazodon

A CASE POSSIBLE SEROTONIN SYNDROME CASE CAUSED BY COMBINED USE OF FLUOXETINE AND LOW DOSE TRAZODONE AND ASSESSED BY THE NARANJO ADVERSE DRUG REACTION PROBABILITY SCALE

Abstract

Serotonin syndrome is a rare but life-threatening syndrome that develops as a result of excessive stimulation of serotonin receptors after the use of serotonergic agents. Clinical signs and symptoms are seen in the cognitive, neuromuscular and autonomic areas. Combination of one or more drugs with serotonergic effect causes this syndrome. While there are cases with a mild clinical appearance that can be overlooked, they can also be life-threatening and require intensive care and mechanical ventilation. In this article, a case of serotonin syndrome, which developed within 24 hours after adding trazodone to fluoxetine treatment and increasing the dose, was presented.

Keywords

• serotonin syndrome
• trazodone
• fluoxetine

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