CORRELATION BETWEEN INFLAMMATORY BLOOD MARKERS AND RECURRENCE RATES FOLLOWING URETHRAL STRICTURE TREATMENT

Abstract

Objective To investigate the relationship between inflammatory markers routinely examined in blood tests and their ratios with the development of recurrence after urethral stricture treatment. Material and Method A total of 142 patients who underwent internal urethrotomy were included in the study. Data were retrospectively reviewed. Patient ages, comorbidity status, medical treatments used, habits, previous surgical procedures, pre- and post-procedural İduroflowmetry values, stricture locations and lengths, and preoperative and postoperative urine and blood test results were recorded. Results The recurrence rate within the first year after internal urethrotomy was determined to be 25.4%. The mean recurrence period was 8.9±1.9 months, ranging from 1 to 12 months, with a median recurrence period of 6 months. When the etiological factors causing urethral stricture were examined, iatrogenic causes were observed to be the most common. There were statistically significant differences in lymphocyte count, platelet count, platelet-lymphocyte ratio, and red cell distribution width-platelet ratio between the group with recurrence and the group without recurrence (p<0.05). Conclusion Platelet-lymphocyte ratio and red cell distribution width-platelet ratio can be used to predict possible recurrences after internal urethrotomy. The main advantages of both parameters are their simplicity, cost-effectiveness, and easy accessibility for clinical use.

Keywords

• Inflammation
• Internal urethrotomy
• Recurrence
• Urethral stricture

ÜRETRAL DARLIK TEDAVİSİ SONRASI GELİŞEN NÜKS ORANLARI İLE İNFLAMATUAR KAN BELİRTEÇLERİ ARASINDAKİ İLİŞKİ

Abstract

Amaç Rutin kan tetkiklerinde çalışılan inflamatuar belirteç ve bu belirteçlerin birbirleriyle oranları ile üretra darlığı tedavisi sonrası gelişen nüks arasındaki ilişkiyi ortaya koymak. Gereç ve Yöntem Çalışmaya internal üretrotomi operasyonu geçiren 142 hasta dahil edildi. Veriler retrospektif olarak tarandı. Hastaların yaşları, eşlik eden komorbidite durumları, kullandıkları tıbbi tedaviler, alışkanlıkları, geçirdikleri cerrahi operasyonlar, işlem öncesi ve sonrasında takiplerdeki üroflowmetre değerleri, darlık lokalizasyonları ve uzunlukları, preoperatif ve post operatif idrar ve kan tahlilleri kaydedildi. Bulgular İnternal üretrotomi operasyonu sonrası ilk bir yılda nüks gelişme oranı %25,4 olarak tespit edildi. Ortalama nüks süresi 8,9±1,9 aydı ve bu süre 1-12 ay arasında değişmekteydi, ortanca nüks süresi ise 6 ay olarak hesaplandı. Üretra darlığına neden olan etyolojik faktörler incelendiğinde, iyatrojenik nedenlerin en yaygın neden olduğu gözlemlendi. Nüks gelişen grup ile gelişmeyen grup arasında lenfosit sayısı, platelet sayısı, platelet-lenfosit oranı, red cell distribution width- platelet oranı bakımından istatistiksel olarak anlamlı farklar bulundu (p<0,05). Sonuç Platelet-lenfosit oranı ve red cell distribution width-platelet oranı, internal üretrotomi sonrası olası nüksler önceden tahmin etmek için kullanılabilir. Her iki parametrenin de basit, ekonomik ve kolayca erişilebilir olması, klinik kullanım açısından en büyük avantajlarıdır.

Keywords

• İnflamasyon
• İnternal üretrotomi
• Üretra darlığı
• Nüks

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