Relationship Between p53 and Recurrence in Endometrial Cancer

Abstract

Objective: Tumor protein 53 (p53), were included in the new FIGO 2023 staging system. Tumor protein 53 (p53) was incorporated into the new FIGO 2023 staging system. This study aimed to assess recurrence rates, overall survival (OS), and progression-free survival (PFS) in endometrial cancer patients with p53 mutations treated in the radiation oncology clinic. Material and Method: 260 patients were included in the study. The patients were divided into 2 groups according to the p53 mutation: p53 abnormal (p53 mutant) and p53 wild type. The Kaplan-Meier method was used to evaluate OS and PFS. Survival rates; were compared in terms of p53 mutations. Patients who underwent surgery for EC between January 1, 2008, and January 1, 2023, were included if their postoperative pathology reports evaluated p53 mutations, and they were referred to the radiation oncology clinic. Results: In our study; OS of EC was 84.2%, PFS was 88.8%. Total of 29 patients (%11.2) with recurrence were detected in the follow-up of the patients. The OS of p53 wild type patients was 88.6% and p53 mutant patients was 61% (p<0.001). The PFS of p53 wild type patients was 91.8% and p53 mutant patients was 73.2% (p<0.001). When risk calculation was made, we found a 4.094-fold increased risk of recurrence in cases with p53 mutation (95% CI: 1.763-9.508). Based on p53 status, 41 patients (15.8%) were classified as the p53 mutant group, while 219 patients (84.2%) were categorized as the p53 wild-type group. Conclusion: As a result, the most important point we want to emphasize in the study is that vaginal cuff recurrence was observed in 3 patients with p53 mutation despite brachytherapy. We found that endometrial cancer with p53 mutation were associated with increased recurrence rate and decreased OS and PFS.

Keywords

• Endometrial carcinoma
• p53
• Recurrence
• Survival

References

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