Association Between Emergency Department Mean Platelet Volume and Angiographic Severity in Unstable Angina: A Prognostic Study

Year 2026, Volume: 33 Issue: 1, 1 - 9, 21.03.2026

Alper Şenol , Furkan Çağrı Oğuzlar , Ezgi Cesur , Hamit Hakan Armağan , Ahmet Yunus Hatip , İsa Gökhan Yalçın , Mustafa Talha Turan

https://doi.org/10.17343/sdutfd.1747150

https://izlik.org/JA96WS32UK

Abstract

Objective
Mean platelet volume (MPV) has been associated
with thrombotic risk and acute coronary syndrome
(ACS) severity in various clinical settings. However,
data regarding its prognostic value in unstable angina
(UA) patients presenting to the emergency department
(ED) are limited. This study aimed to investigate the
relationship between MPV measured at ED admission
and the angiographic severity of ACS, as quantified by
the Gensini score, in patients with UA. A secondary
objective was to assess the predictive value of MPV
for all-cause mortality.

Material and Method
This retrospective cohort study included 203 patients
diagnosed with ACS between July 2022 and July 2023.
MPV and other laboratory parameters were recorded
at the time of admission. Coronary angiography
findings were evaluated using the Gensini scoring
system. Data were analyzed based on Gensini score
categories and mortality status.

Results
MPV values were significantly higher in patients with
high Gensini scores and in those who experienced
mortality (p <0.001). In patients with UA, MPV
demonstrated good predictive value for identifying
high Gensini scores (AUC: 0.807, p = 0.006). MPV,
age, and troponin were associated with angiographic
severity, while MPV, neutrophil-to-lymphocyte ratio
(NLR), and Gensini score were independently
associated with mortality. In the overall cohort, MPV
remained a strong predictor of mortality (AUC = 0.777,
p <0.001). Multivariate analysis revealed that MPV
(OR: 4.503; 95% CI: 1.233–16.443; p = 0.023) and
NLR (OR: 1.826; 95% CI: 1.164–2.864; p = 0.009)
were independent predictors of mortality in patients
with UA.

Conclusion
MPV measured at the time of ED presentation independently predicts angiographic severity and shortterm mortality in patients with unstable angina, underscoring its potential utility for early risk stratification
and management decisions.

Keywords

Acute coronary syndrome , Emergency medicine , Gensini , Mean platelet volume , Mortality

Ethical Statement

This retrospective cohort study was conducted in the Department of Emergency Medicine at Suleyman Demirel University Faculty of Medicine following approval from the Clinical Research Ethics Committee (Approval No: 376, Date: December 29, 2023). Ethical approval and conduct adhered to the principles established by the Declaration of Helsinki (1975 edition, amended in 1983). No written informed consent form was obtained from patients due to retrospective design of the study.

Supporting Institution

Süleyman Demirel University

Thanks

None

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