Administration of Anticonvulsant Drugs by the Intraperitoneal Route

Ruşen Dündaröz; Tuncer Değim; Ali Sızlan; Mehmet Yaşar; Metin Denli; Uğur Tamer

doi:10.17343/sdutfd.27079

Administration of Anticonvulsant Drugs by the Intraperitoneal Route

Abstract

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 1999 Eylül; 6(3) Administration ofAnticonvulsant Drugs by the Intraperitoneal Route Ruşen Dündaröz, Tuncer Değim, Ali Sızlan, Mehmet Yaşar, Metin Denli, Uğur Tamer Abstract Status epilepticus or seizures cause serious brain damages and irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs can be introduced to the patients intravenously (IV), hut it is almost impossible to achieve IV access during the seizure. Intraperitoneal (IP) route can be accessible but, IP route of administration of antiepileptic drugs has not been used so far. Therefore the possibility of IP administration of anti epileptic drugs was investigated in this study. Antiepileptic drug (diazepam, phenytoin or phenobarbital) was introduced rabbits and dogs by IV and IP routes and blood samples were collected by the time during the period of 60 to 120 minutes. Blood samples vere analyzed and drug contents -were determined. The plasma profiles of antiepileptic drugs were obtained and compared. The plasma profiles of antiepileptic drugs were found to be low when they were administered by IP route. It was concluded that the IP administration of antiepileptic drugs could not be an alternative route to IV administration. Key Words: Convulsion, anticonvulsant drugs, Intraperitoneal route Antikonvülzon İlaçların İntraperitonal Yoldan Verilmeleri Özet Epilepsi veya epilepsi nöbeti ciddi beyin hasarlarına neden olabilir, ve eğer fazla uzun sürerse geri dönüşsüz beyin harabiyetine neden olabilir, bu nedenle nöbetin süratle durdurulması oldukça önemlidir. Antiepileptik ilaçlar hastalara intravenöz(IV) yolla verilebilir ancak nöbetler esnasında hastaya IV ulaşım hemen hemen imkansızdır ancak intraperitonal(IP)yol ile ilaç verilmesi mümkündür.

Keywords

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Ruşen Dündaröz This is me

Tuncer Değim This is me

Ali Sızlan This is me

Mehmet Yaşar This is me

Metin Denli This is me

Uğur Tamer This is me

Publication Date

March 12, 2009

Submission Date

March 12, 2009

Acceptance Date

-

Published in Issue

Year 1999 Volume: 6 Number: 3

DOI

https://doi.org/10.17343/sdutfd.27079

IZ

https://izlik.org/JA43RG22GF

Cite

RIS / Bibtex

APA

Dündaröz, R., Değim, T., Sızlan, A., Yaşar, M., Denli, M., & Tamer, U. (2009). Administration of Anticonvulsant Drugs by the Intraperitoneal Route. Medical Journal of Süleyman Demirel University, 6(3). https://doi.org/10.17343/sdutfd.27079

AMA

1.Dündaröz R, Değim T, Sızlan A, Yaşar M, Denli M, Tamer U. Administration of Anticonvulsant Drugs by the Intraperitoneal Route. Med J SDU. 2009;6(3). doi:10.17343/sdutfd.27079

Chicago

Dündaröz, Ruşen, Tuncer Değim, Ali Sızlan, Mehmet Yaşar, Metin Denli, and Uğur Tamer. 2009. “Administration of Anticonvulsant Drugs by the Intraperitoneal Route”. Medical Journal of Süleyman Demirel University 6 (3). https://doi.org/10.17343/sdutfd.27079.

EndNote

Dündaröz R, Değim T, Sızlan A, Yaşar M, Denli M, Tamer U (March 1, 2009) Administration of Anticonvulsant Drugs by the Intraperitoneal Route. Medical Journal of Süleyman Demirel University 6 3

IEEE

[1]R. Dündaröz, T. Değim, A. Sızlan, M. Yaşar, M. Denli, and U. Tamer, “Administration of Anticonvulsant Drugs by the Intraperitoneal Route”, Med J SDU, vol. 6, no. 3, Mar. 2009, doi: 10.17343/sdutfd.27079.

ISNAD

Dündaröz, Ruşen - Değim, Tuncer - Sızlan, Ali - Yaşar, Mehmet - Denli, Metin - Tamer, Uğur. “Administration of Anticonvulsant Drugs by the Intraperitoneal Route”. Medical Journal of Süleyman Demirel University 6/3 (March 1, 2009). https://doi.org/10.17343/sdutfd.27079.

JAMA

1.Dündaröz R, Değim T, Sızlan A, Yaşar M, Denli M, Tamer U. Administration of Anticonvulsant Drugs by the Intraperitoneal Route. Med J SDU. 2009;6. doi:10.17343/sdutfd.27079.

MLA

Dündaröz, Ruşen, et al. “Administration of Anticonvulsant Drugs by the Intraperitoneal Route”. Medical Journal of Süleyman Demirel University, vol. 6, no. 3, Mar. 2009, doi:10.17343/sdutfd.27079.

Vancouver

1.Ruşen Dündaröz, Tuncer Değim, Ali Sızlan, Mehmet Yaşar, Metin Denli, Uğur Tamer. Administration of Anticonvulsant Drugs by the Intraperitoneal Route. Med J SDU. 2009 Mar. 1;6(3). doi:10.17343/sdutfd.27079