Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü

Nilüfer Şahin Calapoğlu; Musatafa Calapoğlu

doi:10.17343/sdutfd.55343

Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü

Abstract

İlerleyici hafıza kaybı, bilişsel yetmezlik ve davranış değişiklikleri ile karakterize Alzheimer hastalığı (AH), beyin yetmezliğinin etiolojik olarak heterojen bir grubunu oluştururken dünya üzerinde de 18 milyondan fazla insanı etkilemektedir. AH kortikal ve subkortikal bölgelerdeki nöronal kaybın yanı sıra b-amiloid (Ab) peptid üretiminin artışı, birikimi ve nörofibriler yumakların (NFT) oluşumu ile ilişkilidir. Doku hasarına karşı birçok farklı hücre tarafından salınan kemokinler ve reseptörlerinin birincil görevleri lökositlerin inflamasyon bölgesine migrasyonunu sağlamaktır. Yapılan son çalışmalar, AH beyni ile inflamatuvar süreçte yer alan kemokinlerin ilişkili olduğuna dikkat çekmektedirler. Bu derlemede, AH'de kemokin ve kemokin reseptörlerinin nöroinflamtuvar rolleri ile ilgili son gelişmeler üzerinde durulmaktadır. Anahtar Kelimeler: Alzheimer hastalığı, inflamasyon, kemokinler, kemokin reseptörleri Abstract The role of chemokine and chemokine receptors in alzheimer's disease Alzheimer's disease (AD) that is an etiologically heterogeneous form of brain failure affects more than 18 million people worldwide and is characterized by progressive memory loss, cognitive impairment and behavioral changes. The disease associated with neuronal loss in cortical and subcortical regions and increased production and accumulation of b-amyloid (Ab) peptide and neurofibrillary tangle (NFT) formation. Chemokines and their receptors are released by different cells in response to tissue injury and their primary function is the migration of leukocytes to inflammatory sides. Recent studies point out that the involvement of chemokines in the inflammatory process associated with AD brain. This review focuses on the recent progress regarding the neuroinflammatory roles of chemokines and chemokin receptor involvement in AD. Key words: Alzheimer's disease, inflammation, chemokines, chemokine receptors

Keywords

Alzheimer hastalýðý, inflamasyon, kemokinler, kemokin reseptörleri

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Nilüfer Şahin Calapoğlu

Musatafa Calapoğlu This is me

Publication Date

December 30, 2009

Submission Date

January 1, 2010

Acceptance Date

-

Published in Issue

Year 2009 Volume: 16 Number: 4

DOI

https://doi.org/10.17343/sdutfd.55343

IZ

https://izlik.org/JA83ZY96ND

Cite

RIS / Bibtex

APA

Şahin Calapoğlu, N., & Calapoğlu, M. (2009). Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü. Medical Journal of Süleyman Demirel University, 16(4), 39-44. https://doi.org/10.17343/sdutfd.55343

AMA

1.Şahin Calapoğlu N, Calapoğlu M. Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü. Med J SDU. 2009;16(4):39-44. doi:10.17343/sdutfd.55343

Chicago

Şahin Calapoğlu, Nilüfer, and Musatafa Calapoğlu. 2009. “Alzheimer Hastalığında Kemokin Ve Kemokin Reseptörlerinin Rolü”. Medical Journal of Süleyman Demirel University 16 (4): 39-44. https://doi.org/10.17343/sdutfd.55343.

EndNote

Şahin Calapoğlu N, Calapoğlu M (December 1, 2009) Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü. Medical Journal of Süleyman Demirel University 16 4 39–44.

IEEE

[1]N. Şahin Calapoğlu and M. Calapoğlu, “Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü”, Med J SDU, vol. 16, no. 4, pp. 39–44, Dec. 2009, doi: 10.17343/sdutfd.55343.

ISNAD

Şahin Calapoğlu, Nilüfer - Calapoğlu, Musatafa. “Alzheimer Hastalığında Kemokin Ve Kemokin Reseptörlerinin Rolü”. Medical Journal of Süleyman Demirel University 16/4 (December 1, 2009): 39-44. https://doi.org/10.17343/sdutfd.55343.

JAMA

1.Şahin Calapoğlu N, Calapoğlu M. Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü. Med J SDU. 2009;16:39–44.

MLA

Şahin Calapoğlu, Nilüfer, and Musatafa Calapoğlu. “Alzheimer Hastalığında Kemokin Ve Kemokin Reseptörlerinin Rolü”. Medical Journal of Süleyman Demirel University, vol. 16, no. 4, Dec. 2009, pp. 39-44, doi:10.17343/sdutfd.55343.

Vancouver

1.Nilüfer Şahin Calapoğlu, Musatafa Calapoğlu. Alzheimer hastalığında kemokin ve kemokin reseptörlerinin rolü. Med J SDU. 2009 Dec. 1;16(4):39-44. doi:10.17343/sdutfd.55343