EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA

Mehmet Aköz

doi:10.17343/sdutfd.45115

EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA

Abstract

ABSTRACT This study was designed to determine the effects of mannitol on tissue Na+/K+-ATP ase enzyme activity and malondialdehyde (MDA) levels in rabbit brain after experimental head trauma. Thirty New Zealand rabbits were divided equally into three groups: Group S(sham-operated group), group C(untreated group) and group M (mannitol treated group). Grup C and group M received head trauma with the weight drop method. Mannitol was administered 1.0 g/ kg i.v. immediately after the head trauma to group M. Head trauma was applied to the right side. One hour after trauma, brain cortices were resected from both sides and the Na+/K+-ATP ase enzyme activity and MDA levels were determined. The results were compared between S, M and C groups (p>0.05). Rectal temparature after the administration of mannitol in group M was found to be lower than groups S and C (p<0.05). [One-way ANOVA test was used for the statistical analysis.] We conclude that Na+/K+-ATP ase activities were increased and MDA levels were decreased in mannitol treated rabbits but the differences were not statistically significant. Key Words: Mannitol, Head trauma, Na+/K+-ATP ase, Malondialdehyde.

Keywords

Mannitol, Kafa travmasi, Na+/K+-ATPaz, Malondialdehyde

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Mehmet Aköz

Publication Date

September 30, 2010

Submission Date

April 29, 2010

Acceptance Date

-

Published in Issue

Year 2010 Volume: 17 Number: 3

DOI

https://doi.org/10.17343/sdutfd.45115

IZ

https://izlik.org/JA54LW44KN

Cite

RIS / Bibtex

APA

Aköz, M. (2010). EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA. Medical Journal of Süleyman Demirel University, 17(3), 7-12. https://doi.org/10.17343/sdutfd.45115

AMA

1.Aköz M. EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA. Med J SDU. 2010;17(3):7-12. doi:10.17343/sdutfd.45115

Chicago

Aköz, Mehmet. 2010. “EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+ ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA”. Medical Journal of Süleyman Demirel University 17 (3): 7-12. https://doi.org/10.17343/sdutfd.45115.

EndNote

Aköz M (September 1, 2010) EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA. Medical Journal of Süleyman Demirel University 17 3 7–12.

IEEE

[1]M. Aköz, “EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA”, Med J SDU, vol. 17, no. 3, pp. 7–12, Sept. 2010, doi: 10.17343/sdutfd.45115.

ISNAD

Aköz, Mehmet. “EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+ ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA”. Medical Journal of Süleyman Demirel University 17/3 (September 1, 2010): 7-12. https://doi.org/10.17343/sdutfd.45115.

JAMA

1.Aköz M. EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA. Med J SDU. 2010;17:7–12.

MLA

Aköz, Mehmet. “EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+ ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA”. Medical Journal of Süleyman Demirel University, vol. 17, no. 3, Sept. 2010, pp. 7-12, doi:10.17343/sdutfd.45115.

Vancouver

1.Mehmet Aköz. EFFECTS OF MANNITOL ON LIPID PEROXIDATION AND Na+-K+/ATPase ENZYME ACTIVITY IN EXPERIMENTAL HEAD TRAUMA. Med J SDU. 2010 Sep. 1;17(3):7-12. doi:10.17343/sdutfd.45115