İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri

Zehra Küçüktepe; Mehmet Özaydın; Yasin Türker; Ercan Varol; Doğan Erdoğan; Abdullah Doğan; Hicran Hiçyılmaz; Hüseyin Vural

doi:10.17343/sdutfd.68233

İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri

Abstract

Amaç: Bu çalışmanın temel amacı, koroner anjiyografide koroner arter ektazisi (KAE) saptanan olgularda asimetrik dimetil arginin (ADMA) düzeylerinin koroner arterleri normal olan ve koroner arter hastalığı (KAH) (çap daralması >%50) olan olgular ile karşılaştırılmasıdır. Metod: Çalışmaya, Ağustos 2007-Şubat 2008 tarihleri arasında koroner anjiyografi yapılan ve çalışmaya alınma kriterlerini karşılayan ardışık 88 hasta dahil edildi. Hastalar, KAE, KAH ve normal koroner arter gruplarından birine alındılar. Çalışmaya alınan hastaların serum örnekleri oda sıcaklığında eritildikten sonra Hasta serum ADMA düzeyleri ELISA yöntemiyle ve nitrik oksid (NO) metabolitleri fotometrik yöntem ile çalışıldı. Bulgular: KAE olan hastalarda istatistiksel olarak anlamlı olmamakla birlikte ADMA düzeyleri KAH (p1: 0.058) ve normal koroner gruplarına göre (p2: 0.08) daha düşük bulundu. Ortalama NO düzeyleri açısından KAE ile KAH arasında ve KAE ile normal koronerler arasında anlamlı fark tespit edilmedi. Sonuç: KAE, KAH ve normal koroner arterleri bulunan hastalar arasında ADMA düzeyleri açısından istatiksel olarak anlamlı fark bulunamadı ancak KAE grubunda KAH ve normal koroner arter gruplarına göre daha düşük olma eğiliminde idi. Anahtar kelimeler: Koroner arter ektazisi, asimetrik dimetil arginin, nitrik oksit Abstract Asymmetric dimethylarginine levels in patients with isolated coronary ectasia Objective: The main objective of this study was to compare the plasma asymmetric dimethylarginine (ADMA) levels between the patients with isolated coronary artery ectasia (CAE) and individuals with normal coronary arteries or patients with coronary artery disease (CAD) (diameter loss>50%). Methods Eighty-eight consecutive patients meeting study inclusion criteria who have undergone coronary angiography between August 2007 and February 2008, were participated in this study. All patients were separated into three groups: CAE, CAD and normal coronary artery. Serum levels of ADMA were measured by using ELISA method and nitric oxide metabolites levels were measured by using photometric method. Results: Although statistically insignificant, serum levels of ADMA was lower in patients with CAE than CAD (p1: 0.058) or normal coronary arteries (p2: 0.08). There was no statistically significantly difference between CAE, normal coronary arteries or CAD with regard to nitric oxide levels. Conclusion: There was no statistically significant difference between CAE, normal coronary arteries and CAD with regard to plasma ADMA levels but there was a trend of lower plasma ADMA levels in patients with CAE compared to normal coronary arteries or CAD. Key words: Coronary ectasia, asymmetric dimethylarginine, nitric oxide

Keywords

Koroner arter ektazisi, asimetrik dimetil arginin, nitrik oksit

References

Swanton RH Lea, Thomas M, Coltart DJ, Jenkins BS, Webb-Peploe MM, Williams BT. Coronary artery ectasia, a variant of occlusive coronary arteriosclerosis. Br Heart J 1978;40:393-400.
Falsetti HL, Carroll RJ. Coronary artery aneurysm. Chest 1976; 69:630-36.
Befeler B, Aranda JM, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: Study of their etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 1977;62:597-607.
Krüger D, Stierle U, Herrmann G, Simon R, Sheikhzadeh A. Exercise-Induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (Dilate coronaropathy). Am J Cardiol 1999; 34:461- 70.
Jian-Jun L, Zheng L, Jie L. Is any link between inflammation and coronary artery ectasia?. Medical Hypotheses 2007;69;678-683.
Böger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardýovascular Research 2003;59:824-833.
Hori T, Matsubara T, Ishibashi T et al. Significance of asymmetric dimethylarginine(ADMA) concentrations during coronary circulation in patients with vasospastic angina. Circ J 2003;67:305-311.
Williams MJA, Stewart RAH. Coronary artery ectasia, local pathology or diffüse disease. Cathet Cardiovasc Diagn 1994;33: 116-119.

Demopoulus VP, Olympios CD, Fakiolas CN, Pissimissis BG, Economides NM, Adamapoulou E, Foussas SG. The natural history of aneurysmal coronary artery disease. Heart 1997;78: 136-41.
Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary artery ectasia. Am J Cardiol 1976; 37:217-22.
Sorrel VL, Davis MJ, Bove AA. Origins of coronary artery ectasia. Lancet 1996; 347:136-37.
Özaydýn M, Kahraman H, Varol E, Aslan SM, Doðan A, Altýnbaþ A. Herbisidlere maruz kalma ile koroner arter ektazisi arasýndaki iliþki. S.D.Ü. Týp Fak. Derg. 2007:14(3): 13-16.
Sudhir K,Ports TA, Amidon TM, Goldgerger JJ, Brushan V, Kane JP, Yock P, Malloy MJ. Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia. Circulation 1995;91:1375-80.
Lu T-M, Ding Y-A, Leu H-B et all. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. The American Journal of Cardiology. 2004;94;:157-161.
Oguz A, Uzunlulu M. Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome. Int Heart J. 2008;49:303-311.
Böger RH, Bode-Böger SM, Szuba A et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842-1847.
Cooke JP. Does ADMA cause endothelial dysfunction? Arteriocler Thromb Vasc Biol 2000;20:2032-2037.
Böger RH. Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond. Annals of medicine 2006;38:126-136.
Wang D, Strandgaard S, Iversen JS, Wilcox CS. Asymmetric Dimethylarginine, Oxidative Stress and Vascular Nitric Oxide Synthase in Essential Hypertension. Am J Physiol Regul Integr Comp Physiol 2009;296: R195-R200.
Yada T, Kaji S, Akasaka T et all. Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. Clin Hemorheol Microcirc. 2007;37;269-76.
Böger RH, Schwedhelm E, Maas R, Quispe-Bravo S, Skamira C. ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study. Vasc Med. 2005;10:97-102.
Sydow K, Münzel T. ADMA and oxidative stress. Atheroscler Suppl. 2003;4:41-51.
Lentz AR, Rodionov RN, Dayal S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk:the potential role of ADMA. Atheroscler Suppl 2003;4:61-65.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Zehra Küçüktepe

Mehmet Özaydın

Yasin Türker This is me

Ercan Varol This is me

Doğan Erdoğan This is me

Abdullah Doğan This is me

Hicran Hiçyılmaz This is me

Hüseyin Vural This is me

Publication Date

March 30, 2010

Submission Date

May 17, 2010

Acceptance Date

-

Published in Issue

Year 2010 Volume: 17 Number: 1

DOI

https://doi.org/10.17343/sdutfd.68233

IZ

https://izlik.org/JA96HR69KJ

Cite

RIS / Bibtex

APA

Küçüktepe, Z., Özaydın, M., Türker, Y., Varol, E., Erdoğan, D., Doğan, A., Hiçyılmaz, H., & Vural, H. (2010). İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri. Medical Journal of Süleyman Demirel University, 17(1), 19-25. https://doi.org/10.17343/sdutfd.68233

AMA

1.Küçüktepe Z, Özaydın M, Türker Y, et al. İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri. Med J SDU. 2010;17(1):19-25. doi:10.17343/sdutfd.68233

Chicago

Küçüktepe, Zehra, Mehmet Özaydın, Yasin Türker, et al. 2010. “İzole Koroner Arter Ektazisi Olan Hastalarda Plazma Asimetrik Dimetil Arginin Düzeyleri”. Medical Journal of Süleyman Demirel University 17 (1): 19-25. https://doi.org/10.17343/sdutfd.68233.

EndNote

Küçüktepe Z, Özaydın M, Türker Y, Varol E, Erdoğan D, Doğan A, Hiçyılmaz H, Vural H (March 1, 2010) İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri. Medical Journal of Süleyman Demirel University 17 1 19–25.

IEEE

[1]Z. Küçüktepe et al., “İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri”, Med J SDU, vol. 17, no. 1, pp. 19–25, Mar. 2010, doi: 10.17343/sdutfd.68233.

ISNAD

Küçüktepe, Zehra - Özaydın, Mehmet - Türker, Yasin - Varol, Ercan - Erdoğan, Doğan - Doğan, Abdullah - Hiçyılmaz, Hicran - Vural, Hüseyin. “İzole Koroner Arter Ektazisi Olan Hastalarda Plazma Asimetrik Dimetil Arginin Düzeyleri”. Medical Journal of Süleyman Demirel University 17/1 (March 1, 2010): 19-25. https://doi.org/10.17343/sdutfd.68233.

JAMA

1.Küçüktepe Z, Özaydın M, Türker Y, Varol E, Erdoğan D, Doğan A, Hiçyılmaz H, Vural H. İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri. Med J SDU. 2010;17:19–25.

MLA

Küçüktepe, Zehra, et al. “İzole Koroner Arter Ektazisi Olan Hastalarda Plazma Asimetrik Dimetil Arginin Düzeyleri”. Medical Journal of Süleyman Demirel University, vol. 17, no. 1, Mar. 2010, pp. 19-25, doi:10.17343/sdutfd.68233.

Vancouver

1.Zehra Küçüktepe, Mehmet Özaydın, Yasin Türker, Ercan Varol, Doğan Erdoğan, Abdullah Doğan, Hicran Hiçyılmaz, Hüseyin Vural. İzole koroner arter ektazisi olan hastalarda plazma asimetrik dimetil arginin düzeyleri. Med J SDU. 2010 Mar. 1;17(1):19-25. doi:10.17343/sdutfd.68233