PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE

Orhan Özatik

doi:10.17343/sdutfd.96983

PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE

Abstract

PANETH CELLS AND MUCOSAL IMMUNITY ABSTRACT Paneth cells constitute small intestine crypts together with columnar, goblet and enteroendocrine cells. Count of them in the crypts gradually increases towards distal regions, with being most excessively in the terminal ileum. More recent hypothesis is that antibiotic peptides are released form intestinal epithelial cells and these peptides are one of the components of mucosal immunity. In mammalian small intestine, paneth cells secrete alpha defensin and additional antimicrobial peptide-containing granules into the lumen between crypts. Alpha defensins are in the same class with nonoxidative microbial cell killer peptides in the phagocytic leukocytes and these effects were also shown in in vitro studies. Injury of crypt and induction of paneth cell insufficiency are compensated with accumulation of cells from crypt centers and release of antimicrobial substances from paneth cells. KEY WORDS: Paneth Cell, Mucosal Immunity, Alpha Defencin PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE ÖZET Paneth hücreleri kolumnar, goblet ve enteroendokrin hücreleriyle birlikte ince barsak kriptalarını oluştururlar. Bu kriptalardaki sayıları ince barsakların distal bölgesine doğru gittikçe artmakta ve en çok terminal ileumda bulunmaktadırlar. Son zamanlarda ortaya çıkan hipotez barsak epitelyal hücrelerinden antibiyotik peptitlerin salınması ve bu peptitlerin de mukozal immünitenin komponentlerinden biri olduğudur. Memeli ince barsaklarında paneth hücreleri, kriptler arasındaki lümene alfa defensin ve ek antimikrobiyal peptit içeren granüller salgılarlar. Alfa defensinler fagositik lökositlerdeki oksidatif olmayan mikrobiyal hücre öldürücü peptitlere eşdeğerdir ve bu etkileri invitro araştırmalarda da gösterilmiştir. Kriptin zarar görmesi veya paneth hücre yetersizliğinin indüklenmesi kript ortalarındaki hücrelerin ortama toplanması ve paneth hücrelerindeki antimikrobiyal maddelerin salınmasıyla kompanze edilmeye çalışılır ANAHTAR KELİMELER:Paneth hücresi, Mukozal İmmünite, Alfa Defensin

Keywords

Soðuk algýnlýðý ilaçlarý, pseudoefedrin, öksürük

References

Pappas DE, Hayden GF, Hendley JO. Treating colds: keep it simple. Contemp Pediatr 1999; 16: 109-119.
Maiman LA, Becker MH, Katlic AW. Correlates of mothers use of medications for their children. Soc Sci Med 1986; 22: 41-51.
Korppi M, Pietikainen M, Laurikainen K, Silvasti M. Antitussives in the treatment of acute transient cough in children. Acta Paediatr Scand 1991; 80: 969-971.
Stuijvenberg van M, Vos de S, Tjiang GCH, Steyerberg EW, Derksen-Lubsen G, Moll HA. Parents fear regarding fever and febrile seizures. Acta Paediatr 1999; 88: 618-622.
Impicciatore P, Nannini S, Pandolfini C, Bonati M. Mothers knowledge of, attitudes toward, and management of fever in preschool in Italy. Prev Med 1998; 27: 268-273.
Smith MB, Feldman W. Over-the-counter cold medications: a critical review of clinical trials between 1950 and 1991. JAMA 1993; 269: 2258-2263.
American Academy of Pediatrics, Committee on Drugs. Use of codeine and dextromethorphan-containing cough remedies in children. Pediatrics 1997; 99: 918-920.
Royal College of General Practitioners, Office of Population Censuses and Surveys, and Department of Health. Morbidity statistics from general practice. Fourth national study 1991-1992. London: HMSO Publications Center, 1992.

Kogan MD, Pappas G, Yu SM, Kotelchuck M. Over- the-counter medication use among U.S. preschool-age children. JAMA 1994; 272: 1025-1030.
Banks I. The NHS direct healthcare guide. London: Department of Health, 2001.
Department of Health. Pharmacy in the future- implanting the NHS plan. A programme for pharmacy in the National Health Service. London: Department of Health, 2000.
Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA. Pseudoephedrine use among US children, 1999-2006: results from the Slone survey. Pediatrics 2008;122: 1299-1304.
Sutter AI, Lemiengre M, Campbell H, Mackinnon HF. Antihistamines for the common cold. Cochrane Database Syst.Rev 2003;3: CD001267.
Isbister GK, Prior F, Kilham HA. Restricting cough and cold medicines in children. J Paediatr Child Health 2010 Jun 27 (Epub ahead of print)
Nine JS, Rund CR. Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature. Am J Forensic Med Pathol 2006; 27: 36-41.
Heikkinen T, Jarvinen A. The common cold. Lancet 2003; 361: 51-59.
Lee AC, Chan R, So KT. A case of probable codeine poisoning in a young infant after the use of a proprietary cough and cold medicine. Hong Kong Med J 2004; 10: 285-287.
Kelly LF. Pediatric cough and cold preparations. Pediatr Rev 2004; 25: 115-123.
Taverner D, Latte J. Nasal decongestants for the common cold. Cochrane Database Syst.Rev. 2007;1: CD001953.
Hatton RC, Winterstein AG, McKelvey RP, Shuster J, Hendeles L. Efficacy and safety of oral phenylephrine: systematic review and meta-analysis. Ann Pharmacother 2007;41: 381-390.
Anonymous. Cough medications in children. Drug Ther Bull 1999; 37: 19-21.
Kernan WN, Viscoli CM, Brass LM, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med 2000; 343: 1826-1832.
Food and Drug Administration. Public Health Advisory Subject: Phenylpropanolamine. Available on line at:www.fdagov/cder/drug/ýnfopage/ppa/advisory.htm.
Clemens CJ, Taylor JA, Almquist JR, Quinn HC, Mehta A, Naylor GS. Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? J Pediatr 1997; 130: 463-466.
Hutton N, Wilson MH, Mellits D, et al. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. J Pediatr 1991; 118: 125-130.
Taylor JA, Novack AH, Almquist JR, Rogers JE. Efficacy of cough suppressants in children. J Pediatr 1993; 122: 799-802.
Rostagno C, Caciolli S, Felici M, Gori F, Neri Serneri GG. Dilated cardiomyopathy associated with chronic consumption of phendimetrazine. Am Heart J 1996; 131: 407-409.
Cetaruk EW, Aaron CK. Hazards of nonprescription medications. Emerg Med Clin North Am 1994; 12: 483-510.
Pentel P. Toxicity of over-the-counter stimulants. JAMA 1984; 252: 1898-1903.
Glick R, Hoying J, Cerullo L, Perlman S. Phenylpropanolamine: an over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Case report and review. Neurosurgery 1987; 20: 969-974.
Kase CS, Foster TE, Reed JE, Spatz El, Girgis GN. Intracerebral hemorrhage and phenylpropanolamine use. Neurology 1987; 37: 399-404.
Burton BT, Rice M, Schmertzler LE. Atrioventricular block following overdose of decongestant cold medication. J Emerg Med 1985; 2: 415- 419.
Lake CR, Gallant S, Masson E, Miller P. Adverse drug effects attributed to phenylpropanolamine: a review of 142 case reports. Am J Med 1990; 89: 195-208.
Conway EE, Walsh CA, Palomba AL. Supraventricular tachycardia following the administration of phenylpropanolamine in an infant. Pediatr Emerg Care 1989; 5: 173-174.
Weesner KM, Denison M, Roberts RJ. Cardiac arrhythmias in an adolescent following ingestion of an over-the-counter stimulant. Clin Pediatr 1982; 21: 700-701.
Veronica L. Gunn, Samina H. Taha, Erica L. Liebelt and Janet R. Serwint. Toxicity of Over-the-Counter Cough and Cold Medications. Pediatrics 2001; 108: 52-57.
Litovitz T, Manoguerra A. Comparison of pediatric poisoning hazards: an analysis of 3.8 million exposure incidents. Pediatrics 1992; 89: 999-1006.
Rivera-Penera T, Gugig R, Davis J, et al. Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. J Pediatr 1997; 130: 300-304.
Holt GA, Hollon JD, Hughes SE, Coyle R. OTC labels: can consumers read and understand them ? Am Pharm 1990;NS30: 51-54.
Kapasi AA, Lorin MI, Nirken MH, Yudovich M. Parents knowledge and sources of knowledge about antipyretic drugs. J Pediatr 1980; 97: 1035-1037.
Bradley CP, Riaz A, Tobias RS, Kenkre JE, Dassu DY. Patient attitudes to over-the-counter drugs and possible professional responses to self-medication. Fam Pract 1998; 15: 44-50.
Dart RC, Paul IM, Bond GR, Winston DC, Manoguerra AS, Palmer RB, et al. Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications. Ann Emerg Med 2009;53: 411-417.
Health Canada (website). Health Canadas decision on cough and cold medicines. Ottawa, ON: Health Canada;2008.
wwwhc-sc.gc.ca/ahc-asc/media/advisories- avis/_2008/2008_184info1-eng.php.
Food and Drug Administration. Using over-the counter cough and cold products in children. Silver Spring. MD: Food and Drug Administration;2008. www.fda.gov/ForConsumers/ConsumerUpdates/ucm 048515.htm.
Shefrin AE, Godman RD. Use of over-the-counter cough and cold medications in children. Can Fam Physician 2009;55: 1081-1083.
Vassilev ZP, Kabadi S, Villa R. Safety and efficacy of over-the-counter cough and cold medicines for use in children. Expert Opin Drug Saf 2010;9: 233-242.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Orhan Özatik

Publication Date

March 30, 2011

Submission Date

November 11, 2010

Acceptance Date

-

Published in Issue

Year 2011 Volume: 18 Number: 1

DOI

https://doi.org/10.17343/sdutfd.96983

IZ

https://izlik.org/JA99ZT86PG

Cite

RIS / Bibtex

APA

Özatik, O. (2011). PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE. Medical Journal of Süleyman Demirel University, 18(1), 25-29. https://doi.org/10.17343/sdutfd.96983

AMA

1.Özatik O. PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE. Med J SDU. 2011;18(1):25-29. doi:10.17343/sdutfd.96983

Chicago

Özatik, Orhan. 2011. “PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE”. Medical Journal of Süleyman Demirel University 18 (1): 25-29. https://doi.org/10.17343/sdutfd.96983.

EndNote

Özatik O (March 1, 2011) PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE. Medical Journal of Süleyman Demirel University 18 1 25–29.

IEEE

[1]O. Özatik, “PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE”, Med J SDU, vol. 18, no. 1, pp. 25–29, Mar. 2011, doi: 10.17343/sdutfd.96983.

ISNAD

Özatik, Orhan. “PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE”. Medical Journal of Süleyman Demirel University 18/1 (March 1, 2011): 25-29. https://doi.org/10.17343/sdutfd.96983.

JAMA

1.Özatik O. PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE. Med J SDU. 2011;18:25–29.

MLA

Özatik, Orhan. “PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE”. Medical Journal of Süleyman Demirel University, vol. 18, no. 1, Mar. 2011, pp. 25-29, doi:10.17343/sdutfd.96983.

Vancouver

1.Orhan Özatik. PANETH HÜCRELERİ VE MUKOZAL İMMÜNİTE. Med J SDU. 2011 Mar. 1;18(1):25-9. doi:10.17343/sdutfd.96983