-

Abstract

Mitral valve thrombosis in third trimester pregnancy: case reportThe incidence of thromboembolic complications are increased in pregnant women with mechanical heartvalves and, thromboembolic events are important complications threating both the lives of mother and fetus.Therefore, ideal anticoagulant theraphy should avoid mechanical heart valve thrombosis and should nothave teratogenic effect itself. But currently, ideal anticoagulant theraphy in pregnant women with mechanicalheart valve remains unclear. In this case report, we present a 30-week-pregnant female patient in whommechanical heart valve thrombosis developed during anticoagulation theraphy with low molecular weightheparin

Keywords

• Pregnancy, mechanical heart valve thrombosis, anticoagulation, low molecular weight heparin

Geç Dönem Gebelikte Mitral Kapak Trombozu: Olgu Sunumu.

Abstract

Mekanik kalp kapağı olan gebe kadınlarda tromboembolik komplikasyon sıklığı artmıştır ve tromboembolik olaylar hem anne hem de fetus yaşamını tehdit eden önemli komplikasyonlardır. Bundan dolayı, ideal antikoagulan tedavi mekanik kalp kapağı trombozunu engellemeli ve kendisi de teratojenik etkiye yol açmamalıdır. Ama, günümüzde mekanik kalp kapağı olan gebe kadınlarda ideal antikoagulan tedavi henüz belirsizliğini korumaktadır. Bu olgu sunumunda, düşük molekül ağırlıklı heparin ile antikoagülan tedavi altında iken mekanik kapak trombozu olan 30 haftalık gebe bir kadın olguyu sunuyoruz.

Keywords

• Gebelik, mekanik kalp kapak trombozu, antikoagulasyon, düþük molekül aðýrlýklý heparin

References

1. 1- Akpýnar O. Gebelik ve Kapak Hastalýklarý. Anadolu Kardiyol Derg 2009; 9 (1): 25-34
2. 2- van Kuilenburg, Verheught FWA, van Dijk APJ. Prosthetic heart valve thrombosis, anticoagulation and pregnancy: a case report and review of literature. Neth Heart J 2007; 15: 306-309
3. 3- Ýnanç MT, Doðdu O, Kaya MG, Doðan A. Gebelerde mekanik kapa trombozu: Ýki olgu sunumu. Türk Kardiyol Dern Arþ. 2009; 37(1): 57-60.
4. 4- Chan WS, Anand S, Ginsberg JS. Anticoagulation pregnant women with mechanical heart valves: a systematic review of the literature. Arc Intern Med 2000;160: 196-201
5. 5- Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, et al. Guidelines on the management of valvular heart disease: The Tasc Force on the management of valvular heart disease of the european society of cardiology. Eur Heart J 2007;28: 230-268
6. 6- Ashour ZA, Shawky HA, Hassan Hussein M. Outcome of pregnancy in women with mechanical valves. Tex Heart Inst J 2000; 27: 240-245
7. 8- Abilgaard U, Sanset PM, Hammerstrom J, Gjestvang FT, Tveit A. Management of pregnant women with mechanical heart valve prosthesis: thromboprophylaxis with low molecular weight heparin. Thromb Res 2009; 124: 262-267.
8. 9- Montalescot G, Polle V, Collet JP, Leprince P, Bellanger A, Gandjbakhch I, et al. Low molecular weight heparin after mechanical heart valve replacement. Circulation 2000; 101: 1083-1086

9. 10-Merli GJ, Groce JB. Pharmacological and Clinical differences between low-molecular-weight heparins. Implications for prescribing practice and therapeutic interchange. P & T 2010; 35: 95-105
10. 11- Danik S, Fuster V. The obstetrical patient with a prosthetic heart valve. Obst Gynecol Clin North Am 2006; 33: 481-491
11. 12-Elkayam U, Singh H, Irani A, Akhter MW. J Cardiovasc Pharmacol Therapeut 2004; 9: 107-115
12. 13-Oran B, Lee-Parritz, Ansell J. Low moleculer weight heparin for the prophylaxis of thromboembolism in women with prosthetic mechanical heart valves during pregnancy. Thromb Haemost 2004; 92: 747-751.