Cadmium exposure increases the amplitudes of spinal reflex responses

Abstract

Objective: Cadmium is an environmental pollutant and which is a potent inhibitor of voltage-dependent calcium channels. It has been shown that cadmium can causes functional disturbances in central and peripheral nervous system. In this study, it has been aimed to investigate the effects of cadmium on the spinal reflexes. Materials and Methods: Fourteen, male rats were divided into two groups: Control and Cadmium. Control group animals received tap water and the rats of Cadmium group received cadmium as in the form of cadmium chloride (70 mg/L) diluted in their drinking water during the experimental period. At the end of the 60 days experimental period, the sciatic nerve was stimulated electrically with single pulses and the reflex potentials were recorded from the ipsilateral L5 ventral root. Results: After the statistical analysis, the reflex response amplitudes were significantly increased in Cadmium group in comparison to the Control group. Conclusion: Subchronic exposure to cadmium affects the rats spinal reflex responses and extrapolation of these results to humans indicate similar possible consequences. 

Keywords

• cadmium
• spinal reflex
• rat

Kadmiyum maruziyeti spinal refleks yanıtlarının amplitüdünü arttırır

Abstract

Amaç: Kadmiyum çevresel bir kirletici ve voltaj baðýmlý kalsiyum kanallarýnýn potent bir inhibitörüdür. Kadmiyumun santral ve periferik sinir sisteminde fonksiyonel bozukluklara neden olabileceði gösterilmiþtir. Bu çalýþmada kadmiyumun spinal reflekslere etkisi araþtýrýlmýþtýr. Gereç ve Yöntemler: 14 adet, erkek sýçan Kontrol ve Kadmiyum grubu olarak ikiye ayrýlmýþtýr. Kontrol grubundaki hayvanlara içme suyu, Kadmiyum grubundaki hayvanlara ise kadmiyum klorür (70 mg/L) içme suyunda çözülerek 60 gün boyunca verilmiþtir. Deneysel periyodun sonunda siyatik sinir elektriksel olarak uyarýlarak L5 ventral kökünden refleks potansiyelleri kaydedilmiþtir. Bulgular: Ýstatistiksel analiz sonrasýnda kadmiyum grubunun refleks yanýtlarýnýn amplitüdleri, kontrol grubuna göre istatistiksel olarak anlamlý düzeyde artmýþ bulunmuþtur. Sonuç: Kadmiyuma subkronik maruziyet spinal refleks yanýtlarýný etkiler ve insanlarda da olasý benzer sonuçlarý düþündürür.

Keywords

• kadmiyum
• spinal refleks
• sýçan

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