The relation of vitamin D with immune system, skin and cancer.

Abstract

The relation of vitamin D with immune system, skin and cancer.In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effectsof sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzymeboth in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitaminD. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are groupedunder three main headings: Regulation of hormone secretion, regulation of immune function, regulation ofcell proliferation and differentiation. The relationship immune system, skin diseases cancer and vitamin Dis the most widely researched topics

Keywords

• Vitamin D
• immune system
• skin
• cancer

D VİTAMİNİNİN İMMÜN SİSTEM, DERİ VE KANSER İLE İLİŞKİSİ

Abstract

İnsanlarda D vitamini ihtiyacının yaklaşık % 95'i güneş ışınlarının etkisiyle deride sentezlenmektedir. Böbrek dışı dokularda da 1-alfa hidroksilaz enzimi aracılığıyla aktif vitamin D sentezi gerçekleşmektedir. D vitamininin reseptör düzeyindeki etkisi aktif vitamin D sayesinde olur. Otuzdan fazla dokuda vitamin D reseptörleri gösterilmiştir. Vitamin D'nin iskelet sistemi dışındaki etkileri 3 ana başlık altında toplanmaktadır: Hormon sekresyonunun regülasyonu, immün fonksiyonların regülasyonu, hücre proliferasyon ve farklılaşmasının düzenlenmesi. İmmun sistem, cilt hastalıkları, kanser vitamin D ile ilişkisi en çok araştırılan konular arasındadır. Anahtar Kelimeler: D vitamini; kemik dışı etkiler; immün sistem; deri; kanser SUMMARY In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effects of sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzyme both in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitamin D. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are grouped under three main headings: Regulation of hormone secretion, regulation of immune function, regulation of cell proliferation and differentiation. The relationship immune system, skin diseases and cancer between vitamin D is the most widely researched topics. Key words: Vitamin D; nonskeletal effects; immune system; skin; cancer

Keywords

• D vitamini
• immün sistem
• deri
• kanser

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