Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi

Fatma Gonca Koçancı; Belma Aslım

doi:10.17343/sdutfd.263872

Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi

Abstract

Alzheimer hastalığı (AH), hafızanın sürekli bir şekilde azalması ile karakterize olan, tedavi edilemeyen, yaşa bağlı nörodejeneratif bir hastalıktır. AH’nin nedenleri tam olarak açıklanamamış olsa da, tau proteinlerinin hiperfosforilasyonunun, mikrotübül stabilizasyonun ve iyon dengesinin bozulmasının, inflamasyon oluşumunun ve apoptozun AH ile ilişkili olduğu bilinmektedir. AH tedavisi için hali hazırda geliştirilen ilaçlar olmasına rağmen, bunlar ancak semptomları yavaşlatarak hastalığın ilerlemesini geciktirmektedir. Mevcut ilaçların klinik çalışmalarda ve pratikte yararları minimaldir ve hiçbiri tam anlamıyla bir tedavi sağlayamamaktadır. Bu nedenle, AH üzerinde etkili olacak koruyucu ve tedavi edici potansiyeli olan yeni ajanların belirlenme çalışmaları önemli bir araştırma alanı haline gelmiştir. Bir treonin ve serin protein fosfataz olan kalsinörinin, AH’de hiperaktivasyonunu kanıtlayan in vitro, ex vivo ve hayvan modellerine ilişkin bilgiler giderek artmaktadır. Bu derleme, kalsinörin mekanizmasını, AH’de görülen kalsinörinin hiperaktivitesine ait kanıtları ve AH tedavisinde bir umut ışığı olarak kalsinörin inhibitörlerinin bellek onarımında, anti-inflamasyonda, tau defosforilasyonunda ve anti-apoptozda nasıl etki ettiğine dair ayrıntıları içermektedir.

Keywords

Alzheimer hastalığı,kalsinörin,kalsinörin inhibitörleri

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Review

Authors

Fatma Gonca Koçancı
Gazi Üniversitesi
Türkiye

Belma Aslım
Gazi Üniversitesi
Türkiye

Publication Date

December 1, 2017

Submission Date

December 27, 2016

Acceptance Date

-

Published in Issue

Year 2017 Volume: 24 Number: 4

DOI

https://doi.org/10.17343/sdutfd.263872

IZ

https://izlik.org/JA56EC27LZ

Cite

RIS / Bibtex

APA

Koçancı, F. G., & Aslım, B. (2017). Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi. Medical Journal of Süleyman Demirel University, 24(4), 178-187. https://doi.org/10.17343/sdutfd.263872

AMA

1.Koçancı FG, Aslım B. Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi. Med J SDU. 2017;24(4):178-187. doi:10.17343/sdutfd.263872

Chicago

Koçancı, Fatma Gonca, and Belma Aslım. 2017. “Kalsinörin Mekanizması Ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi”. Medical Journal of Süleyman Demirel University 24 (4): 178-87. https://doi.org/10.17343/sdutfd.263872.

EndNote

Koçancı FG, Aslım B (December 1, 2017) Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi. Medical Journal of Süleyman Demirel University 24 4 178–187.

IEEE

[1]F. G. Koçancı and B. Aslım, “Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi”, Med J SDU, vol. 24, no. 4, pp. 178–187, Dec. 2017, doi: 10.17343/sdutfd.263872.

ISNAD

Koçancı, Fatma Gonca - Aslım, Belma. “Kalsinörin Mekanizması Ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi”. Medical Journal of Süleyman Demirel University 24/4 (December 1, 2017): 178-187. https://doi.org/10.17343/sdutfd.263872.

JAMA

1.Koçancı FG, Aslım B. Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi. Med J SDU. 2017;24:178–187.

MLA

Koçancı, Fatma Gonca, and Belma Aslım. “Kalsinörin Mekanizması Ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi”. Medical Journal of Süleyman Demirel University, vol. 24, no. 4, Dec. 2017, pp. 178-87, doi:10.17343/sdutfd.263872.

Vancouver

1.Fatma Gonca Koçancı, Belma Aslım. Kalsinörin Mekanizması ve Kalsinörin İnhibitörlerinin Alzheimer Hastalığının Tedavisindeki Önemi. Med J SDU. 2017 Dec. 1;24(4):178-87. doi:10.17343/sdutfd.263872

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