Histomorphometric Evaluation of Bone Regeneration in Peri-Implant Osseous Defects Treated With Titanium Prepared Platelet Rich Fibrin: An Experimental Study in a Rabbit Model

Year 2018, , 243 - 250, 01.09.2018

Hakan Ozdemir , Turan Emre Kuzu

https://doi.org/10.17343/sdutfd.332750

Cited By: 1

Abstract

Aim: The present study aims to investigate the healing of
artificially created peri-implant osseous defects using Titanium-Platelet Rich
Fibrin

Material and
Method: Bone defects (9-mm diameter, 4-mm depth) were created and implant beds
(3-mm diameter, 6-mm depth) were prepared in the middle of them in rabbit
tibias (24 rabbits) used as the experimental model. Afterwards, dental implants were installed into the left and right
tibia (diameter 3.0 mm, length 8 mm). In the experimental groups, the peri-implant
defect was filled with Autogenous grafts (AG), Titanium-Platelet Rich Fibrin (T-PRF),
Biphasic Calcium Phosphate grafts (BCP). The control group did not receive any
filling. The bone-to-implant contact (BIC) was obtained by
histomorphometrically examining the sections taken from the study groups.

Results: AG group was resulted in a high degree of BIC. No
difference of statistical significance was found for the BIC as far as
autogenous graft and PRF groups are concerned.

Conclusion: Peri-implantal defects in regeneration of T-PRF were
found to be nearly as affective as the autogenous bone graft. We, therefore,
conclude that T-PRF can be used for guided bone regeneration in the function of
autogenic matrix in the future.

Keywords

Titanium-prepared-Platelet-Rich-Fibrin, Periimplantal defect, Bone-to-implant contact

Periimplantal Kemik Defektlerinin Titanyum Tüplerde Hazırlanan Trombositten Zengin Fibrin ile Kemik Rejenerasyonunun Histomorfometrik Değerlendirmesi: Tavşan Tibiasinda Deneysel Çalışma

Abstract

Amaç: Bu çalışmanın amacı titanyum tüplerde hazırlanan
trombositten zengin fibrinin (T-PRF) deneysel olarak hazırlanmış periimplantal
kemik defektlerindeki rejenerasyonu incelemektir.

Gereç ve Yöntem: Çalışmada 12 adet erkek wistar rat kullanılmış olup
her bir tavşanın sağ ve sol tibiasına trephan frez ile 7 mm genişliğinde 4 mm
derinliğinde defektler oluşturulmuştur. Daha sonra 3,3X8 mm lik implantlar
tibialara yerleştirilmiş olup periimplantal defektler sırasıyla Otojen greft,
T-PRF, Bifazik Kalsiyum Fosfat greft (BCP) ile restore edilmiştir. Kontrol
grubu boş bırakılıp spontan iyileşmeye bırakılmıştır. 4 hafta sonra tüm
tavşanlar  ötenazi ile öldürülerek
implant ile beraber etrafındaki kemik alındı. Kemik-implant kontağı toludin
mavisi ile boyanan kesitlerin histomorfometrik incelenmesi ile
değerlendirilmiştir.

Bulgular: Otojen grupta (5267,50±228,95) kemik implant kontağı
değeri en yüksek çıkmıştır. Ancak otojen grup ile T-PRF grubu (3932,50±275,50)
arasında istatistiksel olarak bir fark gözlenmemiştir. BCP grubu ile kontrol
grubunda en düşük BIC değerleri gözlenmiştir.

Sonuçlar: Peri-implantal defektlerin rejenerasyonunda T-PRF
grubunda neredeyse otojen grup kadar BIC değerleri bulunmuştur. Bu yüzden T-PRF
gelecekte yönlendirilmiş kemik rejenerasyonunda otojen matriks  fonksiyonu görevi görebilir.

Keywords

Titanyum Trombositten zengin fibrin, periimplantal defekt

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