Kanserde MikroRNA’lar ve İlaç Yanıtı

Çiğdem Aydın Acar; Şükriye Yeşilot

doi:10.17343/sdutfd.345988

Kanserde MikroRNA’lar ve İlaç Yanıtı

Abstract

MikroRNA’lar (miRNA), hedef gen ekspresyonunu post-transkripsiyonel olarak kontrol eden küçük kodlanmayan RNA molekülleridir. miRNA’ların hedef genleri baskılayarak büyüme, gelişme, farklılaşma ve hücre ölümü süreçlerinin düzenlenmesinde önemli rol oynadığına dair çok sayıda çalışma mevcuttur. MiRNA’ların düzenlenmesindeki bozuklukların kanser ile bağlantılı olması bu bağlamda şaşırtıcı değildir. Buna ek olarak, miRNA ifadelerinin ilaçlar tarafından değiştirilebildiği ve miRNA'ların kanser tedavisinde ilaç metabolizmasının düzenlenmesini ve toksisiteyi etkilediği bildirilmiştir. İlaç yanıtı, hem genetik hem de çevresel faktörler tarafından düzenlenen karmaşık bir süreçtir. Bugüne kadar farklı miRNA'ların birçok antikanser terapiye karşı duyarlılığı öngördüğü veya etkilediği bulunmuştur. Bu derleme de, miRNA biyojenezini takiben, miRNA'ların kanser, ilaç yanıtı ve antikanser tedavileri üzerindeki potansiyel rolünü ortaya koyan mevcut çalışmaların tartışılması amaçlanmıştır.

Keywords

MikroRNA; Kanser; İlaç yanıtı

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Details

Primary Language

Turkish

Subjects

Clinical Sciences

Journal Section

Review

Authors

Çiğdem Aydın Acar
MEHMET AKİF ERSOY ÜNİVERSİTESİ
Türkiye

Şükriye Yeşilot
MEHMET AKİF ERSOY ÜNİVERSİTESİ
Türkiye

Publication Date

December 1, 2018

Submission Date

October 23, 2017

Acceptance Date

January 22, 2018

Published in Issue

Year 2018 Volume: 25 Number: 4

DOI

https://doi.org/10.17343/sdutfd.345988

IZ

https://izlik.org/JA54LZ77NS

Cite

RIS / Bibtex

APA

Aydın Acar, Ç., & Yeşilot, Ş. (2018). Kanserde MikroRNA’lar ve İlaç Yanıtı. Medical Journal of Süleyman Demirel University, 25(4), 498-507. https://doi.org/10.17343/sdutfd.345988

AMA

1.Aydın Acar Ç, Yeşilot Ş. Kanserde MikroRNA’lar ve İlaç Yanıtı. Med J SDU. 2018;25(4):498-507. doi:10.17343/sdutfd.345988

Chicago

Aydın Acar, Çiğdem, and Şükriye Yeşilot. 2018. “Kanserde MikroRNA’lar Ve İlaç Yanıtı”. Medical Journal of Süleyman Demirel University 25 (4): 498-507. https://doi.org/10.17343/sdutfd.345988.

EndNote

Aydın Acar Ç, Yeşilot Ş (December 1, 2018) Kanserde MikroRNA’lar ve İlaç Yanıtı. Medical Journal of Süleyman Demirel University 25 4 498–507.

IEEE

[1]Ç. Aydın Acar and Ş. Yeşilot, “Kanserde MikroRNA’lar ve İlaç Yanıtı”, Med J SDU, vol. 25, no. 4, pp. 498–507, Dec. 2018, doi: 10.17343/sdutfd.345988.

ISNAD

Aydın Acar, Çiğdem - Yeşilot, Şükriye. “Kanserde MikroRNA’lar Ve İlaç Yanıtı”. Medical Journal of Süleyman Demirel University 25/4 (December 1, 2018): 498-507. https://doi.org/10.17343/sdutfd.345988.

JAMA

1.Aydın Acar Ç, Yeşilot Ş. Kanserde MikroRNA’lar ve İlaç Yanıtı. Med J SDU. 2018;25:498–507.

MLA

Aydın Acar, Çiğdem, and Şükriye Yeşilot. “Kanserde MikroRNA’lar Ve İlaç Yanıtı”. Medical Journal of Süleyman Demirel University, vol. 25, no. 4, Dec. 2018, pp. 498-07, doi:10.17343/sdutfd.345988.

Vancouver

1.Çiğdem Aydın Acar, Şükriye Yeşilot. Kanserde MikroRNA’lar ve İlaç Yanıtı. Med J SDU. 2018 Dec. 1;25(4):498-507. doi:10.17343/sdutfd.345988