Investigation of the Effects of Magnesium Sulfate Therapy on Recovery in Traumatic Brain Injury

Abstract

Aim

The  incidence of disability and mortality in traumatic brain injuries is high. However there are no proven pharmacologic therapies to prevent these injury. Magnesium plays central pathophysiological  role in trumatic brain injuries. It has been shown that reduced magnesium levels were associated with these injuries. In this study, we investigate the effects of magnesium sulphate in traumatic brain injuries.

Material and Methods

60  traumatic brain injury patients admitted to Antalya Eğitim ve Araştırma Hospital between November 2008 and November2016 were retrospectively analysed.

Results.

60 patients were included in this study (mean age  35.6±17.6 years, 53 male, 7 female). GCS scores were 5 at admission, 7 at the time of discharge in Magnesium Sulphate and control groups, and at the end of two months it was 12 in Magnesium Sulphate group and 9 in control group (P<0.05). Duration in intensive care unit stay was 7 days in both groups. Surgical decompression was performed in 6 (20%) of the Magnesium Sulfate and in 8 of the control group (26.6%). Magnesium administered patients showed a significant positive effect on recovery after 2 months (P<0.05). Mortality after discharge within 1 month was 1 patient (3.33%) in Magnesium Sulfate group and 3 (10%) patients with control group.

 

Conclusion

The results indicate that administration og magnesium sulphate within 12 hours of traumatic brain injury may have neuroprotecitve effects.

Keywords

• Magnezium sulfate,Traumatic brain injury,Treatment

Travmatik Beyin Yaralanmasıda Magnezyum Sülfat Tedavisinin İyileşme Üzerine Etkisinin Araştırılması

Abstract

Amaç

 Travmatik beyin yaralanmalarına bağlı sakat kalma ve ölüm oranı yüksektir. Ancak bu yaralanmaların zararlı sonuçlarına karşı koruma sağlamak için kesin olarak kanıtlanmış farmakolojik tedaviler bulunmamaktadır. Magnezyumun travmatik beyin yaralanmasının patofizyolojisinde merkezi bir rol oynamaktadır. Bu yaralanmalarda magnezyum sülfat seviyelerinde düşme olduğu gösterilmiştir. Bu araştırmada travmatik beyin yaralanmalarında Magnezyum Sülfat tedavisinin etkinliğinin değerlendirilmesi amaçlanmıştır.

Yöntem ve Gereçler

 Kasım 2008 ve Kasım 2016 arasında Antalya Eğitim ve Araştırma Hastanesi yoğun bakım ünitesine kabul edilen travmatik beyin yaralanması olan 18 yaş ve üzeri 60 hasta geriye dönük olarak incelendi. 

Bulgular

Çalışmaya 60 hasta alındı. (ortalama yaş 35.6±17.6, 53 erkek, 7 kadın).  GKS skorları Magnezyum Sülfat grubu ve kontrol grubunda başvuruda 5, taburculuk sırasında 7, iki ayın sonunda Magnezyum Sülfat grubunda 12, kontrol grubunda 9 tespit edildi (P<0.05). Hastaların yoğun bakımda kalış süresi her iki grupta da ortalama 7 gündü. Magnezyum Sülfat alan hastaların 6’ sına (%20), kontrol grubu hastaların ise 8’inin (%26,6) cerrahi olarak dekompresyon yapıldı. Magnezyum sülfat verilen hastalarda 2 ay sonunda iyileşme üzerine anlamlı etki saptandı(p<0.05). Magnezyum Sülfat alan 1 (%3.33) hastanın ve kontrol grubu olan 3 (%10) hastanın  taburcu olduktan sonra takipleri sırasında öldüğü tespit edildi. 

Tartışma ve Sonuç

 Travmatik beyin yaralanmasını takiben 12 saat içerisinde başlanan ve idame ettirilen Magnezyum Sülfat verilmesinin nöroprotektif etki oluştuduğu görüşündeyiz.

Keywords

• Magnezyum sülfat,Travmatik beyin yaralanması,Tedavi

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