Cell Therapies in Kidney Transplantation

Abstract

At the present time, with the development of medicine, surgery and the use of technologically advanced modern drugs, many diseases, including kidney diseases, have  become treatable. Kidney transplantation has become a treatment option for kidney diseases and kidney transplant rates have increased as well as life expectancy has been prolonged by means of obtained success. Immunosuppressive drugs are used in the posttransplant treatment process of renal transplant patients. With the new treatment options, it is aimed to increase the success rate of kidney transplantation and also to eliminate the side effects which are caused by the use of immunosuppressive drugs. Cellular therapies are one of the treatment options that are studied for use in kidney transplantation. Regulator T cells, regulator B cells, regulator macrophages, dendritic cells, mesenchymal stem cells are cell sources that are searched and experimented for use in organ transplantation. It has been shown that successful results have been obtained by using cell therapies in studies carried out with experimental animal models for transplantation. In this review, cell therapies used in and candidate for  renal transplantation are discussed.

Keywords

• Renal transplantation
• cell therapy
• regulatory T cell therapy
• dendritic cell therapy
• mesenchymal stem cell therapy

Böbrek Naklinde Hücresel Tedavilerin Kullanımı

Abstract

Günümüzde, tıp, cerrahi alanında görülen gelişmeler ve teknolojik olarak geliştirilen modern ilaçların kullanımıyla beraber, geçtiğimiz yüzyılda böbrek hastalıkları da dahil olmak üzere, ölümcül olan birçok hastalık artık tedavi edilebilir konuma gelmiştir. Böbrek nakli, elde edilen başarılar ile beraber,  hem böbrek hastalıkları için bir tedavi seçeneği haline gelmiş ve böbrek nakil oranları artış göstermiş, hem de beklenen yaşam süresi uzamıştır. Böbrek nakli yapılan hastaların cerrahi sonrası tedavi süreçlerinde immünsüpresif ilaçlar kullanılmaktadır. Yeni geliştirilmeye çalışılan tedavi seçenekleri ile hem böbrek naklinde elde edilen başarı oranı arttırılmaya çalışılmakta hem de immünsüpresif ilaçların kullanımının yol açtığı yan etkilerin giderilmesi amaçlanmaktadır. Hücresel tedaviler de böbrek naklinde kullanılması için üzerinde çalışılan tedavi seçeneklerinden bir tanesidir. Regülatör T hücreler, regülatör B hücreler, regülatör makrofajlar, dendritik hücreler, mezenkimal kök hücreler, organ nakillerinde kullanılması için araştırma ve deneme yapılan hücre kaynaklarındandır. Deney hayvanlarında nakil modellerinde yapılan çalışmalarda, hücre tedavileri ile başarılı sonuçlar alındığı gösterilmiştir. Bu derlemede böbrek naklinde kullanılan ve de kullanılmaya aday olan hücre tedavileri tartışılmıştır.

Keywords

• Böbrek Nakli
• hücre tedavisi
• regülatör T hücre tedavisi
• dendritik hücre tedavisi
• mezenkimal kök hücre tedavisi

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