Comparison of Freeze-dried Bone Allografts and Demineralized Bone Matrix Combination in Patients with Benign Cystic Lesions and Nonunions

Year 2021, , 23 - 29, 11.03.2021

İbrahim Etli , Nevzat Dabak

https://doi.org/10.17343/sdutfd.625422

Abstract

Objective: The aim of this study was to compare the clinical and radiological results of the patients who treated the combination of Corticospongiosis dried and frozen allograft (AG) with Demineralized Bone Matrix (DBM) and the patients who treated AG in the patients who had bening cystic lesions (BCLs) and nonunion.

Materials and Methods: This retrospective study included patients who had a BCLs and nonunion, who underwent DBM and / or AG during the operation and who followed radiologically and clinically. Patients with BCLs were included in Group I and the patients with nonunion were included in Group II. Group I and Group II patients were divided into two groups as A and B. Patients who treated DBM-AG were included in group A and who treated AG were included in group B. Goldberg radiological evaluation scale was used to evaluate the graft appearance and its union potential.

Results: In this study, 101 patients were included. Forty-eight patients in group I and 53 patients in group II were included. When comparing Group IA with Group IB, there was a significant difference in terms of their radiological scores (p=0.011). When comparing Group IIA with Group IIB, there was a significant difference in terms of their radiological scores (p=0.014). The Group IA and IIA score were statistically significantly higher.

Conclusion: In the treatment of BCLs and nonunion, AG-DBM combination is more effective than AG alone as clinically and radiologically.

Keywords

Demineralized Bone Matrix, Freeze-Dried Bone Allografts, Bening Cystic Lesion, Nonunion

References

• 1.Bigham AS, Dehghani SN, Shafiei Z, Torabi Nezhad S. Xenogenic demineralized bone matrix and fresh autogenous cortical bone J Orthop Traumatol. 2008 Jun; 9 (2): 73-80.1.Bigham AS,
• 2.Sethi AK, Kar IB , Mohanty T, Mishra N, Singh AK. Use of plasma-enriched demineralized freeze-dried bone matrix in postsurgical jaw defects. Natl J Maxillofac Surg. 2018 Jul-Dec;9(2):174-183.
• 3 .Durmuş AS, Çeribaşı AO, C HN. Chorale and Demineralized Bone Matrix Effects on Bone Iodine Equation. F.ü.sağ.bil.vet.derg. 2016; 30 (2): 131 – 136
• 4.Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ. Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery. J Orthop Trauma. 2019 Jan 14.
• 5.Behfarnia P, Shahabooei M, Mashhadiabbas F, Fakhari E. Comparison of bone regeneration using three demineralized freeze-dried bone allografts: A histological and histomorphometric study in rabbit calvaria. Dent Res J (Isfahan). 2012 Sep;9(5):554-60.
• 6. Kaya Y, Şahin S, Application of Demineralized Frozen Dried Bone Allografts in Periodontal Bone Defects and Recent Developments Journal of Hacettepe University Faculty of Dentistry Volume: 34, Issue: 1-2, Pages: 37-45, 2010
• 7. Sheikh Z, Sima C, Glogauer M. Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation Materials 2015, 8, 2953-2993
• 8.Scarano, A. Degidi, M. Iezzi, G. Pecora, G. Piattelli, M.; Orsini, G.; Caputi, S.; Perrotti, V.; Mangano, C.; Piattelli, A. Maxillary sinus augmentation with different biomaterials: A comparative histologic and histomorphometric study in man. Implant Dent. 2006, 15, 197–207.
• 9. Lareau CR, Deren ME, Fantry A, Donahue RM, DiGiovanni CW. Does autogenous bone graft work? A logistic regression analysis. Foot Ankle Surg. 2015 Sep; 21 (3): 150-9
• 10. Bigham AS, Dehghani SN, Shafiei Z, Nezhad ST. Experimental bone: Defect healing with xenogenic bone and bovine fetal growth . Cell Tissue Bank. 2009 Feb; 10 (1): 33-41.
• 11. Y. Fillingham, J. Jacobs Bone grafts and their substitutes Bone Joint J 2016;98-B(1 Suppl A):6–9
• 12. Jorgenson SS, Lowe TG, France J, Sabin J. A prospective analysis of autograft versus allograft. A minimum of 1-year follow-up in 144 patients. 1994 Sep 15; 19 (18): 2048-53.
• 13. Flier MA, Smith WR, Mauffrey C, Irgit K, Williams AE, Ross E, Peacher G, Hak DJ, Stahel PF. Out of employees and complication rates. J Orthop Surg Res. 2013 Sep 9; 8:33. do
• 14. Garg NK, Gam S: Percutaneous autogenous bone marrow grafting in congenital tibial pseudarthrosis. J Bone Joint Surg 77 B: 830-831,1995
• 15. Tted JJ Bremen, GA KL ARVs, Kile Te, Connolly JF. T he role of composite, demineralized bone matrix and bone. Orthopedics 1995; 18: 1153-8
• 16. Upton J, J Glowackl. Hand reconstruction with allograft demineralized bone: twenty-six implants in twelve patients. J Hand Surg (am) .1992; 17: 704-13
• 17. Vaccaro AR, Stubbs HA, Block JE. Dissection of posterolateral spinal fusion. Orthopedics. 2007 Jul; 30 (7): 567-70.
• 18. Cammisa FP Jr , Lowery G, Garfin SR, Geisler FH, Klara PM, McGuire RA, Sassard WR, Stubbs H, Block JE. Two-year fusion rate in Grafton DBM in posterolateral spine fusion: a prospective controlled trial . Spine (Phila Pa 1976). 2004, Mar 15; 29 (6): 660-6.
• 19. Buser Z, Brodke DS, Youssef JA, Rometsch E, Park JB, Yoon ST6 Wang JC, Meisel HJ. Allograft Versus Demineralized Bone Matrix in Instrumented and Noninstrumented Lumbar Fusion: A Systematic Review. Global Spine J. 2018 Jun;8(4):396-412. doi: 10.1177/2192568217735342. Epub 2017 Oct 25.
• 20. Tricot M , Deleu PA , Detrembleur C, Leemrijse T. Clinical assessment of 115 cases of hindfoot fusion with two different types of graft: Allograft+DBM+bone marrow aspirate versus autograft+DBM . Orthop Traumatol Surg Res. 2017 Sep; 103 (5): 697-702.
• 21. Kulachote N, Sa-ngasoongsong P, Sirisreetreerux N, Chanplakorn P, Fuangfa P, Suphachatwong C, Wajanavisit W. Demineralized Bone Matrix Add-On for Acceleration of Bone Healing in Atypical Subtrochanteric Femoral Fracture: A Consecutive Case-Control Study. Biomed Res Int.2016;2016:4061539.
• 22. Di Bella C, Dozza B, Frisoni T, Cevolani L, Donati D.Injection of demineralized bone Clin Orthop Relat Res. 2010 Nov; 468 (11): 3047-55.
• 23. Rougraff BT1, Kling TJ. Treatment of active unicameral bone cysts with percutaneous injection of demineralized bone matrix and autogenous bone marrow. J Bone Joint Surg Am. 2002, Jun. 84-A (6): 921-9.
• 24. Cho HS, Seo SH, Park SH, Park JH, Shin DS, Park IH. Minimal invasive surgery for unicameral bone cyst using demineralized bone matrix: a case series. BMC Musculoskelet Disord. 2012 Jul 29;13:134.
• 25 .Gazdag AR, Lane JM, Glaser D, Forster RA. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg. 1995; 3: 1-8