Böbrek Nakli Alıcılarında Korona Virüsün (COVID-19) Etkisi

Abstract

Koronavirüs hastalığı (Covid-19), ilk olarak Aralık 2019'da Çin'in Hubei eyaletinde bildirilen, sistemik bir solunum yolu hastalığıdır. Covid-19, 11 Mart 2020'de Dünya Sağlık Örgütü tarafından küresel bir pandemi ilan edilmiş ve dünya çapında yüz binlerce insanın ölümüne neden olmuştur. Covid-19, Wuhan şehrindeki hayvan pazarlarında ortaya çıkan, RNA beta koronavirüsü olan yeni şiddetli akut solunum sendromu koronavirüs 2'den (SARS-COV-2) kaynaklanmaktadır. İnsanlarda Covid-19, hava yoluyla kişiden kişiye bulaşan son derece bulaşıcı bir hastalıktır. Yaş kriteri olmaksızın insanları enfekte etme kabiliyetine sahip olan Covid-19, kronik rahatsızlıkları olan hastaların morbidite ve mortalitesinde ciddi bir etkiye sahiptir. Kronik olarak bağışıklık sistemi baskılanması nedeniyle genel popülasyona kıyasla böbrek nakli alıcılarında (KTR), Covid-19 ciddi komplikasyon riskini attırmaktadır. Covid-19’lu KTR’ler genel popülasyona benzer şekilde hafif, orta ve şiddetli olarak klinik belirtiler göstermektedir. Fakat daha ağır seyrinin olabileceği de literatürde mevcuttur. Covid-19’lu KTR’lerde immünsüpresif (IS) ilaçların kullanımının azaltılmasının yarar sağladığı görülmüştür. Antiviral kullanım etkisi ise kişiden kişiye değişiklik göstermektedir. Literatür verilerine göre Covid-19’lu KTR’lerde lenfopeni görülürken IL-6 seviyesinde önemli ölçüde yükselme kaydedilmiştir. Aşı ve deney hayvanları çalışması ise literatürde mevcut değildir.

Keywords

• Covid-19
• KTR
• ACE2 Enzimi

Effect of Corona Virus (COVID-19) in Kidney Transplant Recipients

Abstract

Coronavirus disease (Covid-19) is a systemic respiratory illness first reported in Hubei province of China in December 2019. Covid-19 was declared a global pandemic by the World Health Organization on March 11, 2020, causing the deaths of hundreds of thousands of people worldwide. Covid-19 is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), the RNA beta coronavirus, that appears in animal markets in Wuhan city. In humans, Covid-19 is a highly contagious disease that is transmitted from person to person by air. Covid-19, which has the ability to infect humans without age criteria, has a serious impact on the morbidity and mortality of patients with chronic diseases. Due to chronic immune system suppression In kidney transplant recipients (CTR) compared to the general population, Covid-19 increases the risk of serious complications. CTRs with Covid-19 show clinical symptoms such as mild, moderate and severe similar to the general population. However, it is also available in the literature that it may have a more severe course. It has been observed that it is beneficial in reducing the use of immunosuppressive (IS) drugs in CTRs with Covid-19. The use of antiviral effects varies from person to person. According to the literature data, while lymphopenia was seen in CTRs with Covid-19, a significant increase in IL-6 level was recorded. Vaccine and experimental animal studies are not available in the literature. In this review, it is aimed to discuss the role, epidemiology and symptoms of Covid-19 in CTRs.

Keywords

• Covid-19
• CTR
• ACE2 Enzyme

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