Colchicine and Non-steroidal Anti-inflammatory Drug Applications in the Treatment of COVID-19

Abstract

The new coronavirus disease 2019 (COVID-19) pandemic continues to exist as an unavoidable crisis that affects the whole world. The old drugs with anti-inflammatory activity have come to the fore again in the search for treatment to reduce the morbidity and mortality of the disease. Colchicine is an alternative drug with immunomodulatory and potential anti-viral properties. Control of hyper inflammation triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most important stage for the development of acute respiratory disease syndrome (ARDS). Because of inhibiting different inflammation pathways, colchicine treatment may be effective in preventing the development of ARDS associated with mortality in COVID-19. Again, the lack of immunosuppression effect, ease of use, and being economical are its superior features compared to other drugs. In this review, along with colchicine treatment, non-steroidal anti-inflammatory drug (NSAID) applications used in COVID-19 mostly due to its acute anti-inflammatory effects will be discussed in the light of current information.

Keywords

• Colchicine
• COVID-19
• ARDS
• Ibuprofen

COVID-19 Tedavisinde Kolşisin ve Non-steroid Anti-inflamatuar İlaç Uygulamaları

Abstract

Yeni koronavirus hastalığı 2019 (COVID-19) pandemisi tüm dünyayı etkileyen ve henüz önüne geçilemeyen bir kriz olarak varlığını devam ettirmektedir. Hastalığın morbidite ve mortalitesini azaltacak tedavi arayışları içinde anti-inflamatuar etkinliğe sahip eski ilaçlar tekrar gündeme gelmiştir. Kolşisin immünomodülatör ve potansiyel anti-viral özellikleri ile alternatif bir ilaçtır. Şiddetli akut solunum yolu sendromu koronavirus 2’nin (SARS-CoV-2) tetiklediği hiperinflamasyonun kontrol altına alınması akut solunumsal hastalık sendromu (Akut respiratuar distress sendromu, ARDS) gelişimi için en önemli aşamadır. Farklı inflamasyon yolaklarını inhibe etmesi nedeni ile kolşisin tedavisi COVID-19’da mortalite ile ilişkili ARDS gelişiminin önlemesinde etkili olabilir. Yine immunsupresyon etkisinin olmaması, kullanım kolaylığı ve ekonomik olması diğer ilaçlara göre üstün özellikleridir. Bu derlemede kolşisin tedavisi ile birlikte , akut anti-inflamatuar etkileri nedeni ile COVID-19’da kullanılan non-steroid anti-inflamatuar ilaç (NSAİİ) uygulamalarıda, güncel bilgiler eşliğinde tartışılacaktır.

Keywords

• Kolşisin
• COVID-19
• ARDS
• İbuprofen
• Sitokin

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