MODİFİYE SİSTEMİK İNFLAMASYON SKORU YÜKSEK DERECE DİSPLAZİLİ KOLOREKTAL POLİPLERDE İNVAZİV KARSİNOM VARLIĞINI ÖNGÖRMEDE KULLANILABİLİR

Year 2021, , 507 - 513, 13.09.2021

Tezcan Akın , Serhat Ocaklı , Gizem Güneş , İbrahim Doğan , Merve Akın , Erdinç Çetinkaya , Hüseyin Berkem , Sadettin Er , Mesut Tez

https://doi.org/10.17343/sdutfd.962273

Abstract

Amaç
Son yıllarda sistemik inflamasyon skor (SIS) ve modifiye
sistemik inflamasyon skor (mSIS) gibi skorların
kolorektal kanserlerde prognostik ve prediktif değerleri
araştırılmıştır. Bu çalışmada, basit labaratuvar
testleri ile hesaplanan modifiye sistemik inflamatuar
skorun (mSIS) high grade displazili (HGD) kolon
poliplerinde invaziv karsinom varlığını öngörmedeki
etkinliği araştırıldı.
Gereç ve Yöntem
Ocak 2019 -Ekim 2021 tarihleri arasında preoperatif
HGD tanısıyla opere edilen 44 kolorektal polipli hastanın
postoperatif verileri retrospektif olarak incelendi.
Hastalar postoperatif histopatolojik inceleme sonuçlarına
göre HGD, Tis veya adenomatöz polip ve
invaziv karsinom olarak iki gruba ayrıldı. mSIS hesaplaması;
mSIS 0 [albümin (ALB) ≥ 4.0 g/dL ve lenfosit/
monosit oranı (LMR) ≥ 3.4], mSIS 1 (ALB <4.0
g / dL veya LMR <3.4) ve mSIS 2 (ALB <4.0 g / dL ve
LMR <3.4) şeklinde yapıldı.
Bulgular
Postoperatif patoloji sonuçları HGD, Tis veya adenomatöz
polip olan 17 hastanın 14’ünde (%82,4) mSIS
skoru 0 ve 3’ünde ise (%17,6) mSIS skoru 1 veya 2
olarak saptandı. Patoloji sonuçları invaziv karsinom
olan 27 hastanın 7’sinin (%25,9) mSIS skoru 0 ve
20’sinin (%75,1) mSIS skoru 1 veya 2 olarak bulundu.
Hastaların mSIS skorları ile patoloji sonuçları invaziv
karsinom olan hastalar arasında anlamlı ilişki
bulundu (p<0,05).
Sonuç
HGD’li hastalarda preoperatif dönemde mSIS skoru
hesaplanarak mSIS 1 veya 2 olan hastalarda postoperatif
patoloji sonuçlarının invaziv karsinom olabileceği
öngörülebilir ve tedavi planını belirlemeye
katkısı olabileceği sonucuna varıldı.

Keywords

kolorektal konser, Modifiye sistemik inflamtuar skor, inflamatuar belirteçler, high-grade displazi

THE MODIFIED SYSTEMIC INFLAMMATION SCORE CAN BE USED TO PREDICT THE PRESENCE OF INVASIVE CARCINOMA IN COLORECTAL POLYPS WITH HIGH-GRADE DYSPLASIA

Abstract

Objective
In recent years, the prognostic and predictive values
of scoring systems such as systemic inflammation
score (SIS) and modified systemic inflammation
score (mSIS) have been investigated in colorectal
cancers. To investigate the efficacy of the modified
systemic inflammatory score (mSIS) calculated by
simple laboratory tests in predicting the presence of
invasive carcinoma in colon polyps with high-grade
dysplasia (HGD).
Materials and Methods
The postoperative data of 44 patients with colorectal
polyps who underwent surgery with the diagnosis
of preoperative HGD between January 2019 and
October 2021 were retrospectively analyzed.
According to the results of the postoperative
histopathological examination, the patients were
divided into two groups as HGD/intramucosal
carsinom (Tis)/adenomatous polyp and invasive
carcinoma. mSIS calculation was made as follows:
mSIS 0 [albumin (ALB)≥4.0 g/dL and lymphocyte/
monocyte ratio (LMR)≥3.4], mSIS 1 (ALB<4.0 g/dL
or LMR<3.4) and mSIS 2 (ALB<4.0 g/dL and LMR<
3.4).
Results
According to the postoperative pathology results, the
mSIS score was 0 in 14 (82.4%) of 17 patients with
Tis/adenomatous polyps, and 1 or 2 in three patients
in this group (17.6%). Among the 27 patients with
invasive carcinoma, mSIS was 0 in seven (25.9%)
and 1 or 2 in 20 (75.1%). A significant correlation
was found between mSIS and the pathology results
of the patients with invasive carcinoma (p<0.05).
Conclusion
In patients with HGD, by calculating mSIS in the
preoperative period, the postoperative pathology
results in patients with mSIS 1 or 2 can be predicted
to be invasive carcinoma, which can contribute to the
determination of the appropriate treatment plan.

Keywords

High-grade dysplasia, Colorectal Carcinoma, Inflammatory markers, Modified Systemic Inflammation Score

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