CERRAHİ REZEKSİYON YAPILAN KÜÇÜK HÜCRELİ DIŞI AKCİĞER KANSERLİ KADIN HASTALARDA SAĞKALIMA ETKİ EDEN PROGNOSTİK FAKTÖRLER

Year 2021, , 673 - 680, 30.12.2021

Cemal Aker , Celal Buğra Sezen , Mustafa Vedat Dogru , Ece Yasemin Demirkol , Semih Erduhan , Melek Erk , Yaşar Sönmezoğlu , Özkan Saydam , Levent Cansever , Muzaffer Metin

https://doi.org/10.17343/sdutfd.969715

Abstract

Amaç
Bu çalışmadaki amacımız, küçük hücreli dışı akciğer
kanseri (KHDAK) nedeniyle rezeksiyon uygulanmış
hastalarda prognostik faktörlerin cinsiyete bağlı olarak
etkilerinin ve kadınlarda sağkalıma etki eden faktörlerin
literatür eşliğinde değerlendirilmesidir.
Gereç ve Yöntem
Çalışmaya Ocak 2007-Aralık 2018 yılları arasında
hastanemizde KHDAK nedeniyle akciğer rezeksiyonu
uygulanmış hastalar dahil edilmiştir.1491 hasta çalışmaya
dahil edilmiştir.
Bulgular
Hastaların ortalama yaşı 60,0±8,41 (aralık:26-84)
yıl idi. 1324 (%88,8) erkek hasta, 167 (%11,2) kadın
hasta çalışmada mevcuttu. 406 (%27,2) hastaya
pnömonektomi, 1077 (%72,2) hastaya lobektomi ve 8
hastaya (%0,5) segmentektomi yapılmıştır. Ortalama
5 yıllık sağkalım süresi % 57.5 idi. Çalışmada kadın
hastaların 5 yıllık sağkalım oranı %66,8 iken erkeklerde
%56,4 idi (p=0.005). pN2 durumu değerlendirildiğinde
5 yıllık sağkalım oranı %34,3 iken, pN0 olan
hastalarda sağkalım oranı %64,1 olarak saptanmıştır(
p<0.001). Cox regresyon analizinde sağkalıma
etki eden en önemli prognostik faktörler; cinsiyet, ileri
yaş, geniş rezeksiyon yapmak, pN2 varlığı ve ileri
evre olarak saptanmıştır. Subgrup analizinde kadın
hastalardaki sağkalıma etki eden faktörler değerlendirildiğinde
65 yaş ve üzerinde olan hastalarda 5 yıllık
sağkalım oranı %32.9 olarak saptanmıştır (p<0.001).
Histopatoloji değerlendirildiğinde adenokarsinomlarda
5 yıllık sağkalım oranı %67,1 iken, skuamöz hücreli
kanserlerde %70,7 olarak izlenmiştir.
Sonuç
Çalışmamız sonucunda kadın hastalarda görülen ana
histopatolojik hücretipi adenokarsinomadır. Özellikle
kadınlarda ileri yaş, büyük hücreli kanserler, ileri evre
ve pN2 durumu sağkalımda kötü prognostik faktörlerdir.

Keywords

Akciğer Kanseri, Sağkalım, Prognostik Faktörler

PROGNOSTIC FACTORS FOR THE SURVIVAL OF SURGICALLY TREATED FEMALE PATIENTS FOR NON-SMALL CELL LUNG CANCER

Abstract

Objective
This study aims to evaluate the effects of prognostic
factors depending on gender and the factors affecting
survival in women patients who underwent resection for
non-small cell lung cancer (NSCLC).
Material and Methods
Patients who underwent lung resection due to NSCLC
in our hospital between January 2007 and December
2018 were included in the study. 1491 patients were
included in the study.
Results
The mean age of the patients was 60.0±8.41 (range:
26-84) years. There were 1324 (88.8%) male patients
and 167 (11.2%) female patients. Pneumonectomy
was performed in 406 (27.2%) patients, lobectomy
in 1077 (72.2%) patients, and segmentectomy in 8
patients (0.5%). The mean 5-year survival time was
57.5%. In the study, the 5-year survival rate of female
patients was 66.8%, while it was 56.4% in males
(p=0.005). When the pN2 status was evaluated, the
5-year survival rate was 34.3%, while the survival rate
was 64.1% in patients with pN0 (p<0.001). The most
important prognostic factors affecting survival in Cox
regression analysis were gender, advanced age, wider
resection, pN2, and advanced stage. When the factors
affecting survival in female patients were evaluated
in the subgroup analysis, the 5-year survival rate was
32.9% in patients aged 65 and over (p<0.001). When
the histopathology was evaluated, the 5-year survival
rate was 67.1% in adenocarcinomas, while 70.7% in
squamous cell cancers.
Conclusion
As a result of our study, the main histopathological
cell type seen in female patients is adenocarcinoma.
Especially in women, advanced age, large cell cancers,
advanced stage, and pN2 status are poor prognostic
factors in survival.

Keywords

Lung Cancer, Survival, Prognostic Factors

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