Serebral Palsi'li Hastalarda Tiroid Fonksiyonları ve Bu Hastalarda Phenobarbitalin Tiroid Hormonlarına Etkisi
Abstract
Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 1995 Mart; 2(1)
Serebral Palsi'li Hastalarda Tiroid Fonksiyonları ve Bu Hastalarda Phenobarbitalin Tiroid Hormonlarına Etkisi
BahattinTunç Namık Delibaş Galip Akhan Veysel Tahan Ahmet Rıfat Örmeci
Özet
Serebral palsi'li 44 hastada tiroid fonksiyon testleri tayin edildi. Kontrol grubu olarak 35 sağlam çocuk seçildi. Hasta grubunda T3, T4 ve TSH seviyeleri normal sınırlarda olup, kontrol grubuna göre aradaki fark istatistiksel olarak önemsizdi (p>0.05). Serebral palsi'li hastaların % 43'ü boyca, % 41'i ağırlıkça, % 55'i baş çevresi bakımından 3 persentilin altındaydı. Gelişme geriliği olan hastalarda tiroid fonksiyon testleri kontrol grubuna göre önemli bir farklılık göstermedi (p>0.05). Antikonvülzan olarak phenobarbital alan hastalarda TT4 ve FT4 değerleri ilaç almayanlara göre anlamlı olarak düşüktü (p<0.05).
Anahtar Kelimeler: Serebral palsi, tiroid fonksiyonları, phenobarbital.
Abstract
Thyroid Functions in Children with Cerebral Palsy and Effects of Phenobarbital on Thyroid Hormones
Thyroid function tests were performed on 44 patients with cerebral palsy (CP) and on 35 healthy children as the control group. in the patient group total triiodothyronin (TT3), total thyroxine (TT4), free triiodothyronin (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) levels were found in wholly normal ranges. These values have shown no significant difference with respect to those of the control group (p>0.05). It was striking that 43 %, 41 % and 55 % of the patients were under 3 percentile according to length, weight and head circumference respectively. Thyroid function tests of the patients with growth retardation had no significant difference from those of the controls and patients without growth retardation. The TT4 and FT4 levels in the patients using phenobarbital were considerably lower than those that are not using it (p<0.05). However, there were no significant differences in two groups with respect to T3 and TSH levels.
Key Words: Cerebral palsy, thyroid function, phenobarbital.
Keywords
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Articles |
| Authors | |
| Publication Date | January 20, 2009 |
| Submission Date | January 13, 2009 |
| Published in Issue | Year 1995 Volume: 2 Issue: 1 |
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.