Gastrointestinal sistem amiloidozisine bağlı demir eksikliği anemisi: olgu sunumu

Year 2006, Volume: 13 Issue: 3, 28 - 31, 21.04.2009

Osman Aydın Mehmet Şahin Ülkü Ergene İbrahim Ciriş

Abstract

Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2006 Eylül; 13(3)



Gastrointestinal sistem amiloidozisine bağlı demir eksikliği anemisi: olgu sunumu



Osman Aydın, Mehmet Şahin, Ülkü Ergene,
İbrahim Metin Çiriş



Özet


Gastrointestinal semptomlar sistemik amiloidoziste sıklıkla ortaya çıkar. Amiloidoziste gastrointestinal sistem tutulumuna bağlı olarak obstrüksiyon, ülserasyon, malabsorbsiyon, hemoraji, protein kaybı ve diyare gibi bulgular görülebilir. Amiloidozis hemoraji veya malabsorbsiyona yol açarak demir eksikliği anemisine neden olabilir. Kliniğimize anemi semptomları ile başvuran ve tetkiklerinde demir eksikliği anemisi olduğu anlaşılan hastanın daha ileri incelemelerinde gastrointestinal tutulumlu amiloidozis vakası olduğu saptandı. Demir eksikliği anemisi etyolojisinde amiloidozis nadir görülen bir durum olduğu için olguyu sunmayı amaçladık.



Anahtar kelimeler: amiloidozis, demir eksikliği anemisi, gastrointestinal tutulum











Abstract







Iron deficiency anemia due to amyloidosis involved gastrointestinal tract: a case report.







Gastrointestinal symptoms are common in all systemic types of amyloidosis. The clinical picture of amyloidosis in the gastrointestinal tract can, however, be highly variable and can include obstruction, ulceration, malabsorption, hemorrhage, diarrhea and protein loss. Amyloidosis may be cause iron deficiency anemia due to hemorrhage and malabsorbtion. Our case, who presented with iron deficiency anemia, and was diagnosed as having amyloidosis involved gastrointestinal tract. We aimed this case report because of association with iron deficiency anemia and amyloidosis is very rare condition.







Key words: amyloidosis, iron deficiency anemia, gastrointestinal tract.

Keywords

amiloidozis , demir eksikliði anemisi, gastrointestinal tutulum

References

• Kenneth RB, Franklin BH. Anemias With Disturbed Iron Metaboliz m. In: Kurt JI, Eugene B, Jean DW. Harrison’s Principles of Internal Medicine (13th Ed) . McGraw-Hill Libri, 1996; 1721-1726.
• Hurlston DP. Iron-deficiency anemia complicating AL amyloidosis with recurrent small bowel pseudo- obstruction and hindgut sparing. J Gastroenterol Hepatol 2002;17:623-24.
• Thaler W , Schatzer G, Eder P, Fichtel G. Amyloidosis – an unusual case of recurrent intestinal bleeding and sigmoid perforation: case report with review of the literature. Int J Colorectal Dis 1999;14:297–299.
• Levy DJ, Franklin GO, Rosenthal WS, gastrointestinal bleeding and amyloidosis. Am J Gastroenterol 1982;77:422-6.
• Akbarian M, Fenton J. Perforation of small bowel in amyloidosis. Arch Intern Med 1964, 114 : 815–821.
• Griffel B, Man B, Kraus L Selective massive amyloidosis of small intestine. Arch Surg 1975;110: 215–217.
• Gupta OK, Tandon RK) Intestinal malabsorption, obstruction, bleeding and perforation in primary amyloidosis. J Assoc Physicians India 1976; 24:395–398.
• Rajagopalan AE, Pickleman J. Free perforation of the small intestine. Ann Surg 1982; 196:576–579.
• Miyakawa T, Segi K. Intestinal amyloidosis and perforation of the gastrointestinal tract – a case of jejunal perforation due to amyloidosis. Rinsho Byori 1986; 34:839–844.
• Fraser AG, Nicholson GI. Duodenal perforation in primary systemic amyloidosis. Gut 1992; 33:997–999.
• Ectors NL, Geboes KJ, Rutgeerts PJ. Malabsorption and motor dysfunction in patients with small bowel amyloidosis. Gut 1994; 35:864.
• Tada S, Iida M, Iwashita A et all. Endoscopy and biopsy finding of the upper digestive tract in patients with amyloidosis. Gastrointest. Endosc 1990; 36: 10- 16.
• Çevikbaþ U. Temel patoloji, Nobel Týp Kitabevleri. Ekim 1995; 165-170.
• Gönen Ö. Gastrointestinal Sistem Hastalýklarý. Ýliçin G, Biberoðlu K, Süleymanlar G. Ýç Hastalýklarý (2. Baský). Güneþ Kitabevi. Ankara 2003, Cilt 1; Bölüm 9:1552-53.
• Conrad ME, Umbreit JN. Iron absorption and transport- an update. Am J Hematol 2000; 64:287-98.