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Tiroid lezyonlarında tiroid ince iğne aspirasyon biyopsisi vehistopatoloji sonuçlarının karşılaştırılması

Year 2006, Volume: 13 Issue: 4, 27 - 31, 29.04.2009

Abstract

SüleymanDemirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2006 Aralık; 13(4)


Tiroid lezyonlarında tiroid ince iğne aspirasyon biyopsisi ve
histopatoloji sonuçlarının karşılaştırılması


Gülsün Inan, Sevda Sert, Sema Bircan, Nermin Karahan,
I. Metin Çiriş, Şirin Başpınar, Nilgün Kapucuoğlu



Özet


Amaç: Tiroid ince iğne aspirasyon biyopsi (IIAB) sonuçları ile opere edilen olguların patoloji rapor sonuçları karşılaştırılarak, tiroid lezyonlarının değerlendirilmesinde fakültemizde IIAB.lerinin etkinliğinin saptanması. Hastalar ve Metod: SDÜ Tıp Fakültesinde 2002-2005 yılları arasında IIAB sonrası tiroidektomi yapılan 83 hastanın sitoloji ve histopatoloji sonuçları karşılaştırıldı. IIAB sonuçları benign, malignite kuşkulu, malign ve yetersiz olarak sınıflandırıldı. Bulgular: Seksen üç IIAB materyalinin 45.i (%54.2) benign, 26.sı (%31.3) yetersiz, 8.i (%9.6) malignite kuşkulu, 4.ü (%4.8) maligndir. Sitoloji sonucu benign olarak değerlendirilen olguların 5.i, malignite kuşkulu olarak değerlendirilen olguların 2.si ve malign olarak değerlendirilen olguların 1.i histolojik olarak maligndir. Çalışmamızda duyarlılık %37.5, özgüllük %81.6, tanı değeri %75.4, yanlış pozitiflik değeri %18.3, yanlış negatiflik değeri %62.5, pozitif prediktif değeri %25, negatif prediktif değeri %88.8.dir. Insidental papiller mikrokarsinom tanısı alan olgular dışlandığında duyarlılık %75, özgüllük %81.6, tanı değeri %81.1, yanlış pozitiflik değeri %18.3, yanlış negatiflik değeri %25, pozitif prediktif değeri %25, negatif prediktif değeri %97.5 olarak bulundu. Sonuç: IIAB, tiroid lezyonlarının değerlendirilmesinde papiller mikrokarsinom tanısı dışlandığında değerli bir tanı yöntemidir.



Anahtar kelimeler: Tiroid, IIAB, papiller mikrokarsinom, cerrahi spesmen











Abstract







The comparison of fine needle aspiration biopsy and histopathology results in thyroid lesions







Purpose: To determine the utility of fine needle aspiration biopsy (FNAB) in the evaluation of thyroid lesions at our faculty by comparing the results of FNAB and pathology report results of the patients who underwent surgery. Patients and Method: We compared the cytologic and histopathologic results of 83 patients who underwent thyroidectomies after FNAB at the Suleyman Demirel University School of Medicine between 2002 and 2005. FNAB results were categorized as benign, suspicious for malignancy, malign and insufficient. Results: The diagnosis of FNAB of 83 cases were benign, insufficient, suspicious for malignancy and malign in 45(54.2%), 26(31.3%), 8(9.6%), 4(4.8%) cases respectively. Five of cases which was cytologically diagnosed as benign, 2 of cases which was cytologically diagnosed as suspicious for malignancy and 1 of case which was cytologically diagnosed as malign were found to be malign histologically. Sensitivity, specificity, accuracy, false-positivity, false-negativity, positive predictive value and negative predictive value were 37.5% 81.6%, 75.4%, 18.3%, 62.5%, 25% and 88.8%, respectively. When the incidental papillary microcarcinomas excluded sensitivity, specificity, accuracy, false-positivity, false-negativity, positive predictive value, negative predictive value were changed to 75%, 81.6%, 81.1%, 18.3%, 25%, 25%, 97.5%, respectively. Conclusion: FNAB is a valuable diagnostic method in the evaluation of thyroid lesions when papillary microcarcinomas excluded.







Key words: Thyroid, FNAB, papillary microcarcinoma, surgical specimen

References

  • Ashcraft MW, Van Herle AJ. Management of
  • thyroid nodules II: scanning techniques thyroid suppressive therapy and fine-needle aspiration. Head Neck Surg 1981;3:297-322.
  • Boring CC, Squires TS, Tong T. Cancer statistics 1993. CA Cancer J Clin 1993;43:7-26.
  • Burch HB, Burman KD, Reed HL, Buckner L, Raber T, Ownbey JL. Fine needle aspiration of thyroid nodules determinants of insufficiency rate and malignancy yield at thyroidectomy. Acta Cytol 1996;40:1176-1183.
  • Silverman JF, West LR, Larkin EW, Park KH. The role of fine needle aspiration biopsy in the rapid diagnosis and management of thyroid neoplasm. Cancer 1986;57:1164-1170.
  • Caraway NP, Sneige N, Saman NA. Diagnostic pitfalls in thyroid fine-needle aspiration: a review o f 394 cases. Diagn Cytopathol 1993;9:345-350.
  • Harach HR, Zumsan SB. Cytologic findings in the follicular variant of papillary carcinoma of the thyroid. Acta Cytol 1992;36:142-146.
  • Sidawy MK, Del Vecchio DM, Knoll SM. Fine- needle aspiration of thyroid nodules: correlation between cytology and histology and evaluation of discrepant cases. Cancer 1997;81:253-259.
  • Sarý A, Çetin R, Sarý M, Çandýr Ö. Tiroid lezyonlarýnýn deðerlendirilmesinde ince iðne aspirasyon biyopsisinin yeri. SDÜ Týp Fakültesi Dergisi 1998;5(4):139-143.
  • Singer PA. Evaluation and management of the solitary thyroid nodule. Otolaryngol Clin North Am 1996;29:577-579.
  • Gharib H, Goellner JR. Fine needle aspiration biopsy of the thyroid: an apprasial. Ann Intern Med 1993;118:282-289.
  • Demicco C. Assessment and prospects of thyroid cytology. Ann Endocrinol 1993;54:258-263.
  • Mandreker SRS, Nadkarni NS, Pinto RGW, Menesez S. The role of fine needle aspiration cytology as the initial modality in the investigation of thyroid lesions. Acta Cytol 1995;39:898-904.
  • Rios A, Rodriguez JM, Galindo PJ, Montoya M, Tebar FJ, Sola J, Canteras M, Parrilla P. Utility of fine-needle aspiration for diagnosis of carcinoma associated with multinodular goitre. Clin Endocrinol 2004;61:732-737.
  • Berner A, Pradhan M, Jorgensen L, Heilo A, Groholt KK. Fine needle cytology of the thyroid gland. Tidsskr Nor Laegeforen 2004;124:2359- 2361.
  • Ylagan LR. Fine needle aspiration biopsy of the thyroid: a cytohistologic correlation and study of discrepant cases. Thyroid 2004;14:35-41.
  • Yang GCH, Liebeskind D, Messina AV. Ultrasound-guided fine-needle aspiration of the thyroid assessed by ultrafast papanicolaou stain: data from 1135 biopsies with a two-to six year follow-up. Thyroid 2001;11:581-589.
  • Poller DN, Ibrahin AK, Cummings MH, Mikel JJ, Boote D, Perry M. Fine needle aspiration of the thyroid. Cancer 2000;90:239-244.
  • Gharib H. Fine needle aspiration biopsy of thyroid nodules: advantages, limitations and effect. Mayo Clin Proc 1994;69:44-49.
  • Buley ID. Thyroid gland. In: Gray W, McKee GT. Diagnostic cytopathology (2nd Ed)
  • London, Churchill Livingstone, 2003; 577-602.
Year 2006, Volume: 13 Issue: 4, 27 - 31, 29.04.2009

Abstract

References

  • Ashcraft MW, Van Herle AJ. Management of
  • thyroid nodules II: scanning techniques thyroid suppressive therapy and fine-needle aspiration. Head Neck Surg 1981;3:297-322.
  • Boring CC, Squires TS, Tong T. Cancer statistics 1993. CA Cancer J Clin 1993;43:7-26.
  • Burch HB, Burman KD, Reed HL, Buckner L, Raber T, Ownbey JL. Fine needle aspiration of thyroid nodules determinants of insufficiency rate and malignancy yield at thyroidectomy. Acta Cytol 1996;40:1176-1183.
  • Silverman JF, West LR, Larkin EW, Park KH. The role of fine needle aspiration biopsy in the rapid diagnosis and management of thyroid neoplasm. Cancer 1986;57:1164-1170.
  • Caraway NP, Sneige N, Saman NA. Diagnostic pitfalls in thyroid fine-needle aspiration: a review o f 394 cases. Diagn Cytopathol 1993;9:345-350.
  • Harach HR, Zumsan SB. Cytologic findings in the follicular variant of papillary carcinoma of the thyroid. Acta Cytol 1992;36:142-146.
  • Sidawy MK, Del Vecchio DM, Knoll SM. Fine- needle aspiration of thyroid nodules: correlation between cytology and histology and evaluation of discrepant cases. Cancer 1997;81:253-259.
  • Sarý A, Çetin R, Sarý M, Çandýr Ö. Tiroid lezyonlarýnýn deðerlendirilmesinde ince iðne aspirasyon biyopsisinin yeri. SDÜ Týp Fakültesi Dergisi 1998;5(4):139-143.
  • Singer PA. Evaluation and management of the solitary thyroid nodule. Otolaryngol Clin North Am 1996;29:577-579.
  • Gharib H, Goellner JR. Fine needle aspiration biopsy of the thyroid: an apprasial. Ann Intern Med 1993;118:282-289.
  • Demicco C. Assessment and prospects of thyroid cytology. Ann Endocrinol 1993;54:258-263.
  • Mandreker SRS, Nadkarni NS, Pinto RGW, Menesez S. The role of fine needle aspiration cytology as the initial modality in the investigation of thyroid lesions. Acta Cytol 1995;39:898-904.
  • Rios A, Rodriguez JM, Galindo PJ, Montoya M, Tebar FJ, Sola J, Canteras M, Parrilla P. Utility of fine-needle aspiration for diagnosis of carcinoma associated with multinodular goitre. Clin Endocrinol 2004;61:732-737.
  • Berner A, Pradhan M, Jorgensen L, Heilo A, Groholt KK. Fine needle cytology of the thyroid gland. Tidsskr Nor Laegeforen 2004;124:2359- 2361.
  • Ylagan LR. Fine needle aspiration biopsy of the thyroid: a cytohistologic correlation and study of discrepant cases. Thyroid 2004;14:35-41.
  • Yang GCH, Liebeskind D, Messina AV. Ultrasound-guided fine-needle aspiration of the thyroid assessed by ultrafast papanicolaou stain: data from 1135 biopsies with a two-to six year follow-up. Thyroid 2001;11:581-589.
  • Poller DN, Ibrahin AK, Cummings MH, Mikel JJ, Boote D, Perry M. Fine needle aspiration of the thyroid. Cancer 2000;90:239-244.
  • Gharib H. Fine needle aspiration biopsy of thyroid nodules: advantages, limitations and effect. Mayo Clin Proc 1994;69:44-49.
  • Buley ID. Thyroid gland. In: Gray W, McKee GT. Diagnostic cytopathology (2nd Ed)
  • London, Churchill Livingstone, 2003; 577-602.
There are 21 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Gülsün İnan This is me

Sevda Sert This is me

Sema Bircan This is me

Nermin Karahan This is me

İ.Metin Ciriş This is me

Şirin Başpınar This is me

Nilgün Kapucuoğlu This is me

Publication Date April 29, 2009
Submission Date April 29, 2009
Published in Issue Year 2006 Volume: 13 Issue: 4

Cite

Vancouver İnan G, Sert S, Bircan S, Karahan N, Ciriş İ, Başpınar Ş, Kapucuoğlu N. Tiroid lezyonlarında tiroid ince iğne aspirasyon biyopsisi vehistopatoloji sonuçlarının karşılaştırılması. Med J SDU. 2009;13(4):27-31.

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