Apokrin karsinomun histopatolojik tanısında p63.ün etkinliği; bir aksiller apokrin karsinom olgusu

Şirin Başpınar; Sema Bircan; Nilgün Kapucuoğlu; Birgül Aydoğan

doi:10.17343/sdutfd.88773

Apokrin karsinomun histopatolojik tanısında p63.ün etkinliği; bir aksiller apokrin karsinom olgusu

Year 2007, Volume: 14 Issue: 4, 38 - 40, 06.05.2009

Şirin Başpınar , Sema Bircan Nilgün Kapucuoğlu Birgül Aydoğan

Abstract

Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2007 Aralık; 14(4)

Apokrin karsinomun histopatolojik tanısında p63.ün etkinliği; bir aksiller apokrin karsinom olgusu

Şirin Başpınar, Sema Bircan, Nilgün Kapucuoğlu, Birgül Aydoğan

Süleyman Demirel Üniversitesi Tıp Fakültesi Patoloji AD. Isparta,

Özet

Yetmişaltı yaşında erkek hastanın aksiller bölgesinde apokrin adenomdan gelişen apokrin karsinom olgusu sunulmuştur. Sol aksiller deri lezyonu 5 yıldır yavaş büyümekte olup ağrısızdır. Histolojik incelemede epidermisin altında papiller ve glandüler yapılar oluşturan değişik boyutlarda tümör hücre adaları ile dekapitasyon sekresyonu da izlenmektedir. Tümör komşuluğunda non tümöral apokrin ve sebasöz glandlar bulunmaktadır. Tümör hücreleri "gross cystic disease fluid protein" 15 (GCDFP-15) ile pozitiftir. p63, SMA ve S-100 ile benign apokrin glandların miyoepitelyal hücrelerinde pozitiflik izlenirken, tümörde negatiftir. Olgu tümörün histolojik, immunohistokimyasal bulguları ve yerleşim yerine bağlı olarak apokrin karsinom olarak değerlendirilmiştir. p63.ün apokrin karsinomların tanısını desteklemekte kullanılabileceği düşüncesindeyiz.

Anahtar Kelimeler: Apokrin karsinom, aksilla, p63

Abstract

P63 ın hıstopathologıcal dıagnosıs of apocrıne carcınoma; a case of an axıllary apocrıne carcınoma

We report a case of apocrine carcinoma arising in an apocrine adenoma in the axillary region of a 76 year old man. The left axillary skin lesion showed a slow progressive growth for 5 years and was painless. Histological examination revealed the tumor cell nests of various sizes exhibiting papillary and glandular pattern under the overlying epidermis with decapitaton secretion. Non tumoral apocrine and sebaseous glands were found adjacent to the tumor. The carcinoma cells were positive for GCDFP-15. p63, SMA and S-100 positivity were detected in the myoepithelial cells of benign apocrine glands, but the carcinomatous glands were negative for these proteins. On the basis of its histologic and immunohistochemical features and distinctive location, the tumor was diagnosed as apocrine carcinoma. We think that p63 can be used in supporting the diagnosis of the apocrine carcinoma

Key words: Apocrine carcinoma, axilla, p63

Keywords

Apokrin karsinom, aksilla, p63

References

) Chamberlain RS, Huber K, White JC, Travaglino- Parda R. Apocrine gland carcinoma of the axilla. Review of the literature and recommendations for treatment. Am J Clin Oncol 1999;22(2):131-135
) Yamamoto O, Haratake J, Hisaoka M, Asahi M, Bhawan J. A unique case of apocrine carcinoma on the male pubic skin: Histopathologic and ultrastructural observations. J Cutan Pathol 1993;20:378-383
) Elder D, Elenitsas R, Ragsdale BD. Tumors of the epidermal appendages. In: Elder D, Elenitsas R, Jaworsky C, Johnson B. Levers histopathology of the skin (8th Ed ) Philadelphia New York, Lippincott-Raven, 1997;747-804
) Paties C, Taccagni GL, Papotti M, Valenti G, Zangrandi A, Aloi F. Apocrine carcinoma of the skin: A clinicopathologic immunocytochemical and ultrastructural study. Cancer 1993;71:375- 381
) Warkel RL, Helwig EB. Apocrine gland adenoma and adenocarcinoma of the axilla. Arch Dermatol 1978;114:198-203
) Katagiri Y, Ansai S. Two cases of cutaneous apocrine ductal carcinoma of the axilla. Case report and review of the literature. Dermatology 1999;199:332-337
) Amo Y, Kawano N. A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. J Dermatol 2003;30:72-75
) Yoshida A, Kodama Y, Hatanaka S, Takasaki T, Kuriwaki K, Yoshida H. Apocrine adenocarcinoma of the bilateral axilla. Acta Pathol Jpn 1991;41:927- 932
) Tsujita-Kyutoku M, Kiuchi K, Danbara N, Yuri T, Senzaki H, Tsubura A. p63 expression in normal human epidermis and epidermal appendages and their tumors. J Cutan Pathol 2003;30:11-17
) Reis-Filho JS, Torio B, Albergaria A, Schmitt FC. p63 expression in normal skin and usual cutaneous carcinomas. J Cutan Pathol 2002;29:517-523
)Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy. Mod Pathol 2004;17(3):307-315

Year 2007, Volume: 14 Issue: 4, 38 - 40, 06.05.2009

Şirin Başpınar , Sema Bircan Nilgün Kapucuoğlu Birgül Aydoğan

Abstract

References

) Chamberlain RS, Huber K, White JC, Travaglino- Parda R. Apocrine gland carcinoma of the axilla. Review of the literature and recommendations for treatment. Am J Clin Oncol 1999;22(2):131-135
) Yamamoto O, Haratake J, Hisaoka M, Asahi M, Bhawan J. A unique case of apocrine carcinoma on the male pubic skin: Histopathologic and ultrastructural observations. J Cutan Pathol 1993;20:378-383
) Elder D, Elenitsas R, Ragsdale BD. Tumors of the epidermal appendages. In: Elder D, Elenitsas R, Jaworsky C, Johnson B. Levers histopathology of the skin (8th Ed ) Philadelphia New York, Lippincott-Raven, 1997;747-804
) Paties C, Taccagni GL, Papotti M, Valenti G, Zangrandi A, Aloi F. Apocrine carcinoma of the skin: A clinicopathologic immunocytochemical and ultrastructural study. Cancer 1993;71:375- 381
) Warkel RL, Helwig EB. Apocrine gland adenoma and adenocarcinoma of the axilla. Arch Dermatol 1978;114:198-203
) Katagiri Y, Ansai S. Two cases of cutaneous apocrine ductal carcinoma of the axilla. Case report and review of the literature. Dermatology 1999;199:332-337
) Amo Y, Kawano N. A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. J Dermatol 2003;30:72-75
) Yoshida A, Kodama Y, Hatanaka S, Takasaki T, Kuriwaki K, Yoshida H. Apocrine adenocarcinoma of the bilateral axilla. Acta Pathol Jpn 1991;41:927- 932
) Tsujita-Kyutoku M, Kiuchi K, Danbara N, Yuri T, Senzaki H, Tsubura A. p63 expression in normal human epidermis and epidermal appendages and their tumors. J Cutan Pathol 2003;30:11-17
) Reis-Filho JS, Torio B, Albergaria A, Schmitt FC. p63 expression in normal skin and usual cutaneous carcinomas. J Cutan Pathol 2002;29:517-523
)Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy. Mod Pathol 2004;17(3):307-315

There are 11 citations in total.

Details

Primary Language	English
Journal Section	Case Reports
Authors	Şirin Başpınar Sema Bircan This is me Nilgün Kapucuoğlu This is me Birgül Aydoğan This is me
Publication Date	May 6, 2009
Submission Date	May 6, 2009
Published in Issue	Year 2007 Volume: 14 Issue: 4

Cite

Vancouver	Başpınar Ş, Bircan S, Kapucuoğlu N, Aydoğan B. Apokrin karsinomun histopatolojik tanısında p63.ün etkinliği; bir aksiller apokrin karsinom olgusu. Med J SDU. 2009;14(4):38-40.