Reprodüktif çağdaki kadınlarda toksoplazmozis seroprevalansı

Year 2008, Volume: 15 Issue: 2, 21 - 24, 15.05.2009

Hayati Güneş , Selçuk Kaya Emel Sesli Çetin Tekin Taş Mustafa Demirci

Abstract

Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2008 Mart; 15 (1)

Hayati Güneş Selçuk Kaya, Emel Sesli Çetin, Tekin Taş Mustafa Demirci

Özet
Toksoplazmozis, Toxoplasma gondii.nin sebep olduğu parazitik bir hastalıktır. Gebelik esnasında alınan infeksiyon yenidoğanda intrauterin hasar ve sekellere sebep olabilir. Bu nedenle reprodüktif dönemdeki kadınlarda toksoplazmozis araştırılmalıdır. Ağustos 2005-Temmuz 2006 tarihleri arasında Kadın Hastalıkları ve Doğum servis ve polikliniğine başvuran 18-49 yaş grubundaki 433 hastada toksoplazmozis seroprevalansının
araştırılması amaçlandı. Hastalar 18-25, 26-35 ve 36 olarak 3 yaş grubuna ayrıldı. Anti toxoplasma IgG pozitiflikleri sırasıyla % 21.3, % 26.1 ve % 28.2; anti toxoplasma IgM değerleri ise % 0, % 2.5 ve % 7.3 olarak tespit edildi. 26-35 yaş grubunda bulunan 2 hastada anti toxoplasma IgG avidite değerleri yüksek olarak değerlendirildi. Sonuç olarak, günümüzde reprodüktif dönemdeki kadınlar için halen önemli bir sağlık problemi olarak yerini koruyan toksoplazmozisin seroprevalansının araştırılmasının önemi vurgulanmalıdır.

Anahtar Kelimeler: Toxoplazmozis, reprodüktif dönemdeki kadınlar, seroprevalans.

Abstract

Seroprevalance Of Toxoplasmosis In Reproductive Women

Toxoplasmosis is a parasitic disease caused by a protozoon, Toxoplasma gondii. Infection, acquired during pregnancy may cause intrauterine damage and sequelae in the newborn. Therefore toxoplasmosis must be searched in reproductive women. We aimed to investigate toxoplasmosis seroprevalance in 433 patients (18-49 age group) attending the Obstetric & Gynecology clinic and policlinic of Suleyman Demirel University Researching and Application Hospital between August 2005-July 2006. We separated patients to three groups:
18-25, 26-35 and 36 age groups. IgG positivities were respectively 21.3 %, 26.1% and 28.2%; IgM positivities were respectively 0 %, 2.5 % and 7.3 %.%. IgG avidity results detected from 2 patients in 26-35 age group was high. In conclusion, the importance of searching the seroprevalance of toxoplasmosis, which is stil considered as an important health problem in reproductive women, must be emphasized.

Key Words: Toxoplasmosis, reproductive women, seroprevalance.

Keywords

Toxoplazmozis, reprodüktif dönemdeki kadýnlar, seroprevalans

References

• Kapperud G, Jenum PA, Stray-Pedersen B, Melby KK, Eskild A, Eng J. Risk factors for Toxoplasma gondii infection in pregnancy .Results of a prospective case- control study in Norway Am J Epidemiol 1996; 144:405-12.
• Lynfield R, Guerina NG. Toksoplasmosis Pediatrics in Review. 1997; 18(3): 75-84.
• Daffos F, Forestier F, Capella-Pavlovsky M, Thulliez P, Aufrant C, Valenti D, and Cox WL. Prenatal management of 746 pregnancies at risk for congenital Toksoplasmosis. N Engl J Med 1988; 318:271–275
• Hohlfeld P, Daffos F, Thulliez P, Aufrant C, Couvreur J, MacAleese J et al Fetal Toksoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J. Pediatr. 1989; 115:765–769.
• Remington, JS, McLeod R, and Desmonts G. Toksoplasmosis, p.140–267. In J. S. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant, 4th ed. 1995; The W. B. Saunders Company, Philadelphia Pa.
• Esquivel CA, Sethi S, Janitschke K, Hahn H, Liesenfeld O. Comparison of two commercialy available avidity tests for Toxoplasma-specific IgG antibodies. Arch Med Res 2002; 33:520-523.
• Jenum PA, Stray-Pedersen B, Melby KK, Kapperud G, Whitelaw A, Eskild A et al. Incidence of T. gondii infection in pregnant women. JClin Microbiol 1998; 36: 2907-13.
• Liesenfeld O, Montoya JG, Kinney S, Press C, Remington JS. Effect of testing for IgG avidity in the diagnosis of Toxoplasma gondii infection in pregnant women. Experience in a US reference laboratory. J Infect Dis 2001; 183:1248-1253.
• Prince HE, Wilson M. Simplified assay for measuring Toxoplasma gondii immunoglobulin G avidity. Clin D i a g n L a b I m m u n o l 2 0 0 1 ; 8 ( 5 ) : 9 0 4 - 9 0 8 .
• Aspock H, Pollak A. Prevention of prenatal Toksoplasmosis by serological screening of pregnant women in Austria. Scand J Infect Dis 1992; 84(suppl): 32-7.
• Montoya JG, Remington JS. Toxoplasma gondii. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Disesases. Fifth edition. Churchill Livingstone 2001;Volume 2, Chapter 268, p.2858- 2888.
• Foulon W, Naessens A, Volckaert M, Lauwers S, Amy JJ. Congenital Toksoplasmosis: a prospective survey in Brussels. Br. J Obstet Gynaecol 1984; 91: 419-23.
• Koppe JG, Loewer-Sieger DH, de Roever-Bonnet H. Results of 20 year follow-up of congenital Toksoplasmosis Lancet 1986; 254-5.
• Wilson CB, Remington JS, Stagno S, Reynolds DW. Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection. Pediatrics. 1980; 66: 767-74.
• Altýntaþ N, Yolasýðmaz A, Yazar S, Þakru N, Kitapcýoðlu G. Ýzmir ve çevresindeki yerleþim bölgelerinde yaþayan insanlarda Toxoplasma antikorlarýnýn araþtýrýlmasý. T. Parasitol Derg 1998; 22(3): 229-32.
• Kuman HA, Altýntaþ N, Ak M. Ege bölgesinde Toksoplasmosis rastlanma sýklýðý. T. Parasitol Derg 1987; 11: 49-63.
• Sütcü A, Tuncer Ý, Kuru C, Baykan M. Konya ve çevresinde IgG ve IgM prevalansý. T. Parasitol Derg 1998; 1: 3-7.
• Yiðit N, Aktaþ AE, Uslu H, Aydýn F, Babacan M. Atatürk Üniversitesi Týp fakültesi Mikrobiyoloji laboratuvarýna gelen Toksoplasmosis þüpheli hasta serumlarýnda Toxoplasma gondi antikorlarýnýn araþtýrýlmasý. T. Parasitol Derg 2000; 24: 22-24.
• Demirci M, Arýdoðan BC, Can R ve Kaya S. Isparta’da deðiþik gruplarda toxoplazmosis seroprevalansý. Türkiye Parazitoloji Dergisi; 2001; 25(2):107-109.
• Foudnier F, Chemia CM, Pinon J. Value of specific immunglobulin A detection by two immunocapture assays in the diagnosis of Toksoplasmosis. Eur J Microbiol Infect Dis, 1995; 14(7):585-590.
• Montoya JG, Liesenfeld O, Kinney S, Press C, Remington JS, Vidas test for avidity of Toxoplasma- IgG for confirmatory testing of pregnant women. J C l i n M i c r o b i o l , 2 0 0 2 ; 4 0 ( 7 ) : 2 5 0 4 - 2 5 0 8 .
• Foudnier F, Chemia CM, Pinon J. Value of specific immunglobulin A detection by two immunocapture assays in the diagnosis of Toksoplasmosis. Eur J Microbiol Infect Dis 1995; 14(7):585-590.
• Logar J, Novak-Antolic Z, Zore A. Improved diagnosis of Toksoplasmosis acquired during pregnancy by determination of specific IgG avidity. IX. International Congres of Parasitology; ICOPA IX Chiba Japan 1998; 1259-1262.
• Remington JS, Thulliez P, Montoya JG, Minireviev Recent developments for diagnosis of Toksoplasmosis. J Clin Microbiol, 2004; 42(3):941-945.
• Sobieszczanska B, Przondo-Mordarska A, IgG toxo avidity in serodiagnosis of acute Toksoplasmosis. 11th ECCMID Ýstanbul, Turkey 2001; 1-4 April, P1419.
• Robert-Gangneux F, Gavinet MF, Ancelle T, Raymond J, Tourte-Schaefer C, Dupouy-Camet J. Value of Prenatal Diagnosis and Early Postnatal Diagnosis of Congenital Toksoplasmosis. Retrospective Study of 110 cases. J Clin Microbiol 1999; 37 (9): 2893-8.