A case of acute myocardial infarction: progressing with leukemoid reaction

Year 2010, Volume: 17 Issue: 4, 22 - 24, 30.12.2010

Abdülkerim Tamer , Selim Topçu Hüsnü Değirmenci Habip Emre Fuat Gündoğdu İlhami Kiki

Abstract

Leukemoid reaction is a hematological disorder, defined by a leukocyte count greater than 50,000 cells/mL and increased neutrophil ratio in blood smear, caused by reactive causes outside the bone marrow. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia and chronic neutrophilic leukemia and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. In our case, a 79 years old woman was admitted our hospital with leukemoid reaction and acute myocardial infarction. After detecting the underlying cause of leukemoid reaction, we thought the leukemoid reaction is secondary of acute myocardial infarction.

Keywords

Leukemoid reaction, Myocardial Infarction, progressing with leukemoid

Lökomoid Reaksiyon İle Seyreden Bir Akut Miyokard İnfarktüsü Olgusu

Abstract

Lökomoid reaksiyon lökosit sayımının kemik iliği dışındaki reaktif sebeplere bağlı olarak 50,000 hücre/ μL üzerine çıkması olarak tanımlanan hematolojik bir hastalıktır. Diagnostik çalışmalar kronik myelojenik lösemi ve kronik nötrofilik löseminin dışlanmasını ve altta yatan sebebin araştırılmasını gerektirir. Lökomoid reaksiyonun major sebeplerini şiddetli infeksiyonlar, intoksikasyonlar, malignensiler, şiddetli kanamalar veya akut hemoliz oluşturmaktadır. Bizim olgumuzda 79 yaşında bayan hasta hastanemize lökomoid reaksiyon ve akut miyokardiyal infarktüs tanıları ile yatırıldı. Lökomoid reaksiyonun altında yatabilecek sebepler araştırıldığında, akut myokard infarktüsüne sekonder olduğu düşünüldü.

Anahtar Kelimeler: Lökomoid Reaksiyon; Miyokard İnfarktüsü

Abstract:

A Case Of Acute Myocardial Infarctus Which Progressing With Leukemoid Reaction

Leukemoid reaction is a hematological disorder, defined by a leukocyte count greater than 50,000 cells/μL, caused by reactive causes outside the bone marrow. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia and chronic neutrophilic leukemia and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. In our case, a 79 years old woman was admitted our hospital with leukemoid reaction and acute myocardial infarctus. After detecting the underlying cause of leukemoid reaction, we thought the leukemoid reaction is secondary of akut myocardial infarktus.

Key Words: Leukemoid reaction; Myocardial Infarctus.

Keywords

Lökomoid Reaksiyon, Miyokard Ýnfarktüsü, Akut Miyokard

References

• Curnutte JT and Coates TD.Disorders of Phagocyte Function and Number. In: Hoffman R,Benz Jr: EJ, Shattil SJ.Furie B. Hematology Basic Principles and Practice 3 rd ed.Churchill Livingstone,Philadelphia. 2000; 720-762
• Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med 2006; 17:394–398
• Kaptan K, Kocabalkan F, Aydýn A, Sayal A, Iþýmer A. Akut miyokard infarktüsünde lökosit agregasyonu ile glutatyon peroksidaz ve süperoksid dismutaz aktivite düzeylerinin takibi. T klin kardiyoloji 1996; 9:6-11.
• Öztürk Ö, Toprak N. Akut Anterior Miyokard Ýnfarktüslü Hastalarda Geliþ Miyokardiyal Performans Ýndeksi ile Lökositoz Arasýndaki Ýliþki. Dicle Týp Dergisi 2004;2:31-36
• Barron HV, Cannon CP, Murphy SA, Braunwald E, Gibson CM. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial. Infarction : a thrombolysis ýn myocardial ýnfarction 10 substudy. Circulation 2000;102;2329-2334
• Sabatine MS, Morrow DA, Cannon CP, Murphy SA, Demopoulos LA, DiBattiste PM, et al. J Am Coll Cardiol. 2002;40(10):1761-8.