The answer of the entero endocrin system in immun supressive rats.

Year 2011, Volume: 18 Issue: 1, 1 - 5, 30.03.2011

Orhan Özatik

Abstract

Human body has lots of defense mechanisms. One of these mechanisms is the well-known mucosal immune system. Paneth cells exist in the small intestine and enteroendocrine cells are also a part of this mucosal immune system. In this study, we studied the response of these cells when the immune system was suppressed. In the present study, we used 14 wistar Albino rats and applied immune supression in half of them.The another half of the rats were used as a control group.The materials taken from the rats were evaluated by applying histologic technics. Paneth cells, enteroendocrin cells, granülles of mast cells and their numbers were examined. Although similar morphological characteristics were observed in both the paneth cells and the enteroendocrin cells in the immune supressed and the control group, an increase in the mast cells were observed. Coke and basillus were found to be existed in the cript lumene and were also in great number.This increasing in the suppression of immune system is the result of deficient defence mechanism. On the other hand, the increase in the mast cells might be the result of a compansatory defence mechanism.

Keywords

immune system, mast cell, paneth cell, immune supression

İMMÜN SÜPRESSİF RATLARDA ENTERO ENDOKRİN SİSTEM YANITI

Abstract

nsan vücudunda pek çok savunma mekanizmasý mevcuttur. Bu savunma mekanizmalarýndan bir tanesi de mukozal immün sistemdir. Ýnce barsaklarda bulunan paneth hücreleri ve enteroendokrin hücreler de bu mukozal immün sistemin bir parçasýdýr. Bu çalýþmada Ýmmün sistem baskýlandýðýnda bu hücrelerin verdiði yanýt araþtýrýlmýþtýr. Çalýþmada 14 adet Wistar Albino sýçan kullanýlýp yarýsýna immün süpresyon uygulandý. Diðer yarýsý kontrol grubu olarak kullanýldý. Sýçanlardan elde edilen materyaller histolojik teknikler uygulanýp deðerlendirildi. Paneth hücreleri, enteroendokrin hücreler, mast hücreleri granülleri ve sayýlarý incelendi. Ýmmün süpresyon uygulanan grupta paneth hücrelerinde ve enteroendokrin hücrelerde kontrol grubuyla
ayný özelliklerde morfolojiler tespit edilmesine raðmen, mast hücrelerinde sayýca artýþ görülmüþtür. Ayrýca kript lümeninde bulunan kok ve basiller çok fazla miktarda artmýþtýr. Bu artýþ immün sistemin baskýlanmasý sonucu savunma mekanizmasýnýn yeterince çalýþamamasý sebebiyle olmaktadýr. Mast hücrelerindeki artýþýn savunma mekanizmasý kompanzasyonu için olduðu düþünülmüþtür.

Keywords

immün sistem, mast hücreleri, paneth hücreleri, immün süpresyon

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