Yaşlılık ve oksidatif stres

Year 2012, Volume: 19 Issue: 2, 68 - 74, 30.06.2012

Serdal Öğüt , Emrah Atay

Abstract

Serbest radikaller, bir atom ya da molekül yörüngesinde eşleşmemiş bir elektron içeren yüksek oranda reaktif kimyasal ürünler olarak adlandırılmaktadır. Biyolojik sistemlerdeki en önemli serbest radikaller oksijenden oluşan radikallerdir ve bunlara reaktif oksijen türleri adı da verilmektedir ve reaktif oksijen türleri oksidatif stres oluşumuna neden olurlar. Oksidatif stres; oksidan oluşumu ve antioksidan savunma arasındaki dengenin oksidanlar yönünde bozulması durumudur. Oksidatif stres; kanser, kalp hastalıkları, diyabet ve diyabetin komplikasyonları başta olmak üzere pek çok patolojik tablonun ve yaşlanmanın patogenezi ile yakın ilişkidedir. Şiddetli ve kalıcı oksidatif stres varlığında gerçekleşen apoptozis, yaşlanma ile insidensi artan alzeimer hastalığı ve parkinson gibi benzer hastalıklarda artmaktadır. 

Keywords

Serbest radikaller, reaktif oksijen türleri, oksidatif stres, yaşlanma

Aging and oxidative stress

Abstract

Aging includes, mixed process that includes such as genetics, life style, variables chronic disease. Free radicals are highly reactive chemicals which contain an electron that isnt matched in an atom or molecule orbital. The most fundemental free radicals in biological systems are the ones that consist of oxygen and they are called reactive oxygen species and they cause oxidative stres formation. Oxidative stres is the corruption case of the balance between oxygen formation and antioxidant defense in the direction of the oxidants..It is in a close relationship with such pathogenesis of many pathological tables and aging mainly as cancer,heart diseases, diabetes and diabetes complications. Apoptosis that occurs in the existence of severe and persistent oxidative stress increases in such diseases as Alzeimer and Parkinson whose incidence increases by aging.

Keywords

Free radicals, reactive oxygen species, oxidative stres, aging

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