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Eosinophilic Gastrointestinal Disorders

Year 2015, Volume: 22 Issue: 1, 27 - 31, 30.03.2015

Abstract

Eosinophilic Gastrointestinal Disorders are caused by excessive levels of eosinophils in various parts of the gastrointestinal tract. There are several subcategories of eosinophilic gastrointestinal disorders including eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis. These diseases has become increasingly recognized recently in both pediatric and adult populations. Symptoms of eosinophilic gastrointestinal disorders are nausea, vomiting, diarrhea, abdominal pain, poor growth or weight loss and dysphagia. Main therapeutic options are steroids and dietary modification. In this article we tried to review eosinophilic gastrointestinal diseases under the highlight of the recent studies

References

  • Spergel JM .Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. - J Pediatr Gastroenterol Nutr. 2011; 52(3): 300-6
  • Jo Y. Eosinophilic esophagitis: update 2012. Korean J Gastroenterol. 2012 Jul;60(1):3-12.
  • Mahreema J, Ghulamullah S, and Paul M. Eosinophilic Gastrointestinal Diseases: Review and Update. ISRN Gastroenterol. 2012; 2012: 463689.
  • Nielsen RG, Husby S. Eosinophilic oesophagitis: epidemiology, clinical aspects, and association to allergy. J Pediatr Gastroenterol Nutr 2007;45:281–9.
  • Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut 2007;56(5):615-620.
  • Furuta GT, Forbes D, Boey C, et al. Eosinophilic gastrointestinal diseases (EGIDs). J Pediatr Gastroenterol Nutr 2008;47(2)
  • Mirna C, Hugh A.S. Epidemiology and Etiology of Eosinophilic Esophagitis. Gastrointestinal Endoscopy Clinics of North America – 2008;18:1
  • Alfredo JL, Angel A. Eosinophilic Gastroenteritis. An Update. Expert Rev Gastroenterol Hepatol. 2012;6(5):591-601.
  • Akyüz U, Akyüz F, Ozdil K, et al. Food impaction in older age: Think about an eosinophilic esophagitis. World J Gastrointest Endosc. 2013;5(2):79-80.
  • Alfredo JL, Marta SC. Adult versus pediatric eosinophilic esophagitis: important differences and similarities for the clinician to understand. Expert Review of Clinical Immunology.2012;8(8):733-745
  • Agrawal N, Rani UK, Sridhar R, et al. Eosinophilic gastroenteritis: a diagnosis behind the curtains. J Clin Diagn Res. 2012 ;6(10):1789-90.
  • Yamada Y, Nishi A, Ebara Y et al. Eosinophilic gastrointestinal disorders in infants: a Japanese case series. Int Arch allergy Immunol.2011;155(1):40-5
  • Okpara N, Aswad B, Gyorgy B. Eosinophilic colitis. World J Gastroenterol. 2009 ; 15(24): 2975–2979.
  • Carol RP. Eosinophilic gastrointestinal disorders. Practical Gastroenterology . 2007; 48: 53-67.
  • Rothenberg ME, Eosinophilic gastrointestinal disorders (EGID). The Journal of Allergy and Clinical Immunology 2004:113(1);11-28
  • Hurrell JM, Genta RM, Melton SD. histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract. Adv Anat Pathol. 2011; 18(5):335-48
  • Rothenberg ME, Mishra A, Collins MH, et al. Pathogenesis and clinical features of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2001;108(6):891–894.
  • Yamada Y, Nishi A, Ebara Y et al. Eosinophilic gastrointestinal disorders in infants: a Japanese case series. Int Arch allergy Immunol.2011;155(1):40-5
  • David MF. Eosinophilic Gastrointestinal Diseases: Evaluation of the Patient with Suspected Eosinophilic Gastrointestinal Disease. Immunol Allergy Clin North Am. 2009;29(1):53-63
  • Seema A, Ikuo H, Glenn T, et al. Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding. Semin Immunopathol. 2012;34:715-731
  • David MF. Eosinophilic Gastrointestinal Diseases: Evaluation of the Patient with Suspected Eosinophilic Gastrointestinal Disease. Immunol Allergy Clin North Am. 2009;29(1):53-63
  • Justinich C, Katz A, Gurbindo C, et al: Elemental diet proves steroid dependent eosinophilic gastroenteritis and reverses growth failure. J Pediatr Gastroenterol Nutr. 1996;23:81- 85
  • Aceves SS, Furuta Gt, Spechler SJ. Integrated approach to treatment of children and adults with eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008;18:195
  • Krarup AL, Villadsen GE, Mejlgaard E, et al. Acid hypersensitivity in patients with eosinophilic oesophagitis. Scand J Gastroenterol 2010; 45:273.
  • Shauna S, David MF Joanne CM, et al. Successful treatment of eosinophilic esophagitis with ciclesonide. Journal of Allergy and Clinical Immunology. 2012;129(5):1419-21
  • Liacouras CA. Pharmacologic Treatment of Eosinophilic Esophagitis. Gastrointest Endosc Clin N Am. 2008;18(1):169-78
  • Michael PS, Fergal D, Gabor K. Safe and effective dilatation in eosinophilic esophagitis: the tale of two subgroups. Gastrointest Endosc. 2011;73(2):408
  • Stein ML, Collins MH, Villanueva JM, et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 2006; 118:1312
  • 29 .Chang JY, Choung RS, Lee RM et al. A shift in the clinical spectrum of eosinophilic gastroenteritis toward the mucosal disease type. Clin. Gastroenterol. Hepatol. 2010:8(8); 669–675
  • Stuart C, Wade W. Eosinophilic esophagitis. Allergy Asthma Clin Immunol. 2011; 7(1):8
  • Pineton G, Gonzalez F, Canva JY, et al. Natural history of eosinophilic gastroenteritis. Clin Gastroenterol Hepatol. 2011;9(11):950-956
  • Abdulrahman A. Alfadda MD, Martin A, Et al. Eosinophilic Colitis: Epidemiology, Clinical Features, and Current Management. Ther Adv Gastroenterol. 2011;4(5):301-309

Eosinofilik gastrointestinal hastalıklar

Year 2015, Volume: 22 Issue: 1, 27 - 31, 30.03.2015

Abstract

Eosinofilik gastrointestinal hastalıklar sindirim sisteminin farklı bölümlerinde fazla miktarda eosinofil birikimiyle karekterizedir. Eosinofilik gastrointestinal hastalıklar tutulum bölgesine göre eosinofilik özefajit, eosinofilik gastroenterit ve eosinofilik kolit olarak alt kategorilere ayrılır. Bu hastalıklar hem çocuk hem de erişkin populasyonunda gittikçe artan bir sıklıkta tanı almaktadırlar. Tipik olarak 3. ve 5. dekatlarda görülmektedir. Eosinofilik gastrointestinal hastalıkların semptomları çeşitlidir ama bulantı, kusma, karın ağrısı, kilo kaybı ya da gelişme geriliği ve yutkunma zorluğu vardır. Ana tedavi seçeneklerini steroidler ve diyet değişiklikleri içerir. Bu yazıda son çalışmalar ışığında eozinofilik gastrointestinal hastalıklar gözden geçirildi.

References

  • Spergel JM .Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. - J Pediatr Gastroenterol Nutr. 2011; 52(3): 300-6
  • Jo Y. Eosinophilic esophagitis: update 2012. Korean J Gastroenterol. 2012 Jul;60(1):3-12.
  • Mahreema J, Ghulamullah S, and Paul M. Eosinophilic Gastrointestinal Diseases: Review and Update. ISRN Gastroenterol. 2012; 2012: 463689.
  • Nielsen RG, Husby S. Eosinophilic oesophagitis: epidemiology, clinical aspects, and association to allergy. J Pediatr Gastroenterol Nutr 2007;45:281–9.
  • Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut 2007;56(5):615-620.
  • Furuta GT, Forbes D, Boey C, et al. Eosinophilic gastrointestinal diseases (EGIDs). J Pediatr Gastroenterol Nutr 2008;47(2)
  • Mirna C, Hugh A.S. Epidemiology and Etiology of Eosinophilic Esophagitis. Gastrointestinal Endoscopy Clinics of North America – 2008;18:1
  • Alfredo JL, Angel A. Eosinophilic Gastroenteritis. An Update. Expert Rev Gastroenterol Hepatol. 2012;6(5):591-601.
  • Akyüz U, Akyüz F, Ozdil K, et al. Food impaction in older age: Think about an eosinophilic esophagitis. World J Gastrointest Endosc. 2013;5(2):79-80.
  • Alfredo JL, Marta SC. Adult versus pediatric eosinophilic esophagitis: important differences and similarities for the clinician to understand. Expert Review of Clinical Immunology.2012;8(8):733-745
  • Agrawal N, Rani UK, Sridhar R, et al. Eosinophilic gastroenteritis: a diagnosis behind the curtains. J Clin Diagn Res. 2012 ;6(10):1789-90.
  • Yamada Y, Nishi A, Ebara Y et al. Eosinophilic gastrointestinal disorders in infants: a Japanese case series. Int Arch allergy Immunol.2011;155(1):40-5
  • Okpara N, Aswad B, Gyorgy B. Eosinophilic colitis. World J Gastroenterol. 2009 ; 15(24): 2975–2979.
  • Carol RP. Eosinophilic gastrointestinal disorders. Practical Gastroenterology . 2007; 48: 53-67.
  • Rothenberg ME, Eosinophilic gastrointestinal disorders (EGID). The Journal of Allergy and Clinical Immunology 2004:113(1);11-28
  • Hurrell JM, Genta RM, Melton SD. histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract. Adv Anat Pathol. 2011; 18(5):335-48
  • Rothenberg ME, Mishra A, Collins MH, et al. Pathogenesis and clinical features of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2001;108(6):891–894.
  • Yamada Y, Nishi A, Ebara Y et al. Eosinophilic gastrointestinal disorders in infants: a Japanese case series. Int Arch allergy Immunol.2011;155(1):40-5
  • David MF. Eosinophilic Gastrointestinal Diseases: Evaluation of the Patient with Suspected Eosinophilic Gastrointestinal Disease. Immunol Allergy Clin North Am. 2009;29(1):53-63
  • Seema A, Ikuo H, Glenn T, et al. Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding. Semin Immunopathol. 2012;34:715-731
  • David MF. Eosinophilic Gastrointestinal Diseases: Evaluation of the Patient with Suspected Eosinophilic Gastrointestinal Disease. Immunol Allergy Clin North Am. 2009;29(1):53-63
  • Justinich C, Katz A, Gurbindo C, et al: Elemental diet proves steroid dependent eosinophilic gastroenteritis and reverses growth failure. J Pediatr Gastroenterol Nutr. 1996;23:81- 85
  • Aceves SS, Furuta Gt, Spechler SJ. Integrated approach to treatment of children and adults with eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008;18:195
  • Krarup AL, Villadsen GE, Mejlgaard E, et al. Acid hypersensitivity in patients with eosinophilic oesophagitis. Scand J Gastroenterol 2010; 45:273.
  • Shauna S, David MF Joanne CM, et al. Successful treatment of eosinophilic esophagitis with ciclesonide. Journal of Allergy and Clinical Immunology. 2012;129(5):1419-21
  • Liacouras CA. Pharmacologic Treatment of Eosinophilic Esophagitis. Gastrointest Endosc Clin N Am. 2008;18(1):169-78
  • Michael PS, Fergal D, Gabor K. Safe and effective dilatation in eosinophilic esophagitis: the tale of two subgroups. Gastrointest Endosc. 2011;73(2):408
  • Stein ML, Collins MH, Villanueva JM, et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 2006; 118:1312
  • 29 .Chang JY, Choung RS, Lee RM et al. A shift in the clinical spectrum of eosinophilic gastroenteritis toward the mucosal disease type. Clin. Gastroenterol. Hepatol. 2010:8(8); 669–675
  • Stuart C, Wade W. Eosinophilic esophagitis. Allergy Asthma Clin Immunol. 2011; 7(1):8
  • Pineton G, Gonzalez F, Canva JY, et al. Natural history of eosinophilic gastroenteritis. Clin Gastroenterol Hepatol. 2011;9(11):950-956
  • Abdulrahman A. Alfadda MD, Martin A, Et al. Eosinophilic Colitis: Epidemiology, Clinical Features, and Current Management. Ther Adv Gastroenterol. 2011;4(5):301-309
There are 32 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Reviews
Authors

Eylem Sevinç

Publication Date March 30, 2015
Submission Date February 24, 2013
Published in Issue Year 2015 Volume: 22 Issue: 1

Cite

Vancouver Sevinç E. Eosinophilic Gastrointestinal Disorders. Med J SDU. 2015;22(1):27-31.

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