Kanserde MikroRNA’lar ve İlaç Yanıtı

Year 2018, Volume: 25 Issue: 4, 498 - 507, 01.12.2018

Çiğdem Aydın Acar , Şükriye Yeşilot

https://doi.org/10.17343/sdutfd.345988

Abstract

MikroRNA’lar
(miRNA), hedef gen ekspresyonunu post-transkripsiyonel olarak kontrol eden
küçük kodlanmayan RNA molekülleridir. miRNA’ların hedef genleri baskılayarak
büyüme, gelişme, farklılaşma ve hücre ölümü süreçlerinin düzenlenmesinde önemli
rol oynadığına dair çok sayıda çalışma mevcuttur. MiRNA’ların düzenlenmesindeki
bozuklukların kanser ile bağlantılı olması bu bağlamda şaşırtıcı değildir. Buna
ek olarak, miRNA
ifadelerinin ilaçlar tarafından değiştirilebildiği ve miRNA'ların kanser
tedavisinde ilaç metabolizmasının düzenlenmesini ve toksisiteyi etkilediği
bildirilmiştir. İlaç yanıtı, hem
genetik hem de çevresel faktörler tarafından düzenlenen karmaşık bir süreçtir.
Bugüne kadar farklı miRNA'ların birçok antikanser terapiye karşı duyarlılığı
öngördüğü veya etkilediği bulunmuştur. Bu derleme de, miRNA biyojenezini takiben,
miRNA'ların kanser, ilaç yanıtı ve antikanser tedavileri üzerindeki potansiyel
rolünü ortaya koyan mevcut çalışmaların tartışılması  amaçlanmıştır. 

Keywords

MikroRNA; Kanser; İlaç yanıtı

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