Review
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Kanserde MikroRNA’lar ve İlaç Yanıtı

Year 2018, Volume: 25 Issue: 4, 498 - 507, 01.12.2018
https://doi.org/10.17343/sdutfd.345988

Abstract

MikroRNA’lar
(miRNA), hedef gen ekspresyonunu post-transkripsiyonel olarak kontrol eden
küçük kodlanmayan RNA molekülleridir. miRNA’ların hedef genleri baskılayarak
büyüme, gelişme, farklılaşma ve hücre ölümü süreçlerinin düzenlenmesinde önemli
rol oynadığına dair çok sayıda çalışma mevcuttur. MiRNA’ların düzenlenmesindeki
bozuklukların kanser ile bağlantılı olması bu bağlamda şaşırtıcı değildir. Buna
ek olarak, m
iRNA
ifadelerinin ilaçlar tarafından değiştirilebildiği ve miRNA'ların kanser
tedavisinde ilaç metabolizmasının düzenlenmesini ve toksisiteyi etkilediği
bildirilmiştir.
İlaç yanıtı, hem
genetik hem de çevresel faktörler tarafından düzenlenen karmaşık bir süreçtir.
Bugüne kadar farklı miRNA'ların birçok antikanser terapiye karşı duyarlılığı
öngördüğü veya etkilediği bulunmuştur. Bu
derleme de, miRNA biyojenezini takiben,
miRNA'ların kanser, ilaç yanıtı ve antikanser tedavileri üzerindeki potansiyel
rolünü ortaya koyan mevcut çalışmaların tartışılması  amaçlanmıştır. 

References

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Year 2018, Volume: 25 Issue: 4, 498 - 507, 01.12.2018
https://doi.org/10.17343/sdutfd.345988

Abstract

References

  • 1. Kusenda B, Mraz M, Mayer J, Pospisilova S. MicroRNA biogenesis, functionality and cancer relevance. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2006; 150: 205–15.
  • 2. Narry KV. Small RNAs: Classification, Biogenesis, and Function. Mol Cells 2005; 19(1):1-15.
  • 3. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNAs host genes and transcription units. Genome Res 2004; 14: 1902–1910
  • 4. Lee RC, Feinbaum RL, Ambros V. The C. Elegans heterochronic gene Lin-4 encodes small RNAs with antisense complementarity to Lin-14. Cell 1993; 75 (5): 843–845
  • 5. http://www.mirbase.org
  • 6. Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 2004;23(20):4051-60.
  • 7. Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004;10(12):1957-66.
  • 8. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, Kim VN. The nuclear RNase Drosha initiates microRNA processing. Nature 2003;425(6956):415-9.
  • 9. Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of premicroRNA precursors. Genes Dev 2003;17(24):3011-6.
  • 10. Ketting RF, Fischer SE, Bernstein E, Sijen T, Hannon GJ, Plasterk RH. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 2001;15(20):2654-9.
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  • 12. Bushati N, Cohen SM. microRNA functions. Annu Rev Cell Dev Biol 2007;23:175-205.
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  • 14. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell 2003;115(2):199-208.
  • 15. Lee S, Choi E, Cha M, Hwang KC. Implications of MicroRNAs in the Vascular Homeostasis and Remodeling, Muscle Cell and Tissue 2015. https://www.intechopen.com/books/muscle-cell-and-tissue/implications-of-micrornas-in-the-vascular-homeostasis-and-remodeling
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  • 17. Koturbash I, Beland FA, Pogribny IP. Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants. Expert Opin Drug Metab Toxicol 2012; 8(5): 597–606.
  • 18. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev Genet 2004; 5(7): 522–531.
  • 19. Wu L, Fan J, Belasco JG. MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 2006; 103(11):4034–4039.
  • 20. Karagün BŞ, Bülen, Antmen B, Şaşmaz İ, Kılınç Y. Mikro RNA ve Kanser. Türk Klinik Biyokimya Derg 2014; 12(1): 45-56.
  • 21. Sun W, Li YSJ, Huang HD, Shyy JYJ, Chien S. MicroRNA: A Master Regulator of Cellular Processes for Bioengineering Systems. Annu Rev Biomed Eng 2010; 12: 1-27.
  • 22. Pillai RS. MicroRNA function: multiple mechanisms fora tiny RNA. RNA 2005;11(12):1753-61.
  • 23. Calin GA, Croce CM. MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 2006, 66:7390-7394.
  • 24. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008;451:147-152.
  • 25. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H. MicroRNA-21 (miR-21) posttranscriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2007; 27:2128-2136.
  • 26. Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 2008;10:202-210.
  • 27. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9:189-198.
  • 28. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002;99(24):15524-9.
  • 29. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005;102:13944-13949.
  • 30. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. RAS is regulated by the let-7 microRNA family. Cell 2005;120(5):635–647.
  • 31. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64(11); 3753–3756.
  • 32. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005;353(17):1793–1801.
  • 33. Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. High expression of precursor microRNA-155/ BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer 2004;39:167–169.
  • 34. Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, Kroesen BJ, van den Berg A. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005; 207(2): 243–249.
  • 35. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65(16):7065–7070.
  • 36. Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, Sabatino G et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem. Biophys Res Commun 2005;334(4):1351– 1358.
  • 37. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103(7): 2257–2261.
  • 38. Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65(14):6029–6033.
  • 39. Le Quesne J, Caldas C. Micro-RNAs and breast cancer. Moleculer Oncology 2010; 4(3): 230-41.
  • 40. He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S. The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA 2005; 102(52): 19075-80.
  • 41. Sevli S, Uzumcu A, Solak M, Ittmann M, Ozen M. The function microRNAs, small potent molecules in human prostate cancer. Prostate Cancer Prostatic Dis 2010; 13(3): 208-17.
  • 42. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 2005; 65(21): 9628-32.
  • 43. Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006; 25(17): 2537-45.
  • 44. Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Can cer Res 2003;1(12): 882- 91
  • 45. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences USA 2008;105(30):10513-10518.
  • 46. Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecologic Oncology 2008; 110(1):13-21.
  • 47. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Research 2008;18(10):997-1006.
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There are 73 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Reviews
Authors

Çiğdem Aydın Acar

Şükriye Yeşilot

Publication Date December 1, 2018
Submission Date October 23, 2017
Acceptance Date January 22, 2018
Published in Issue Year 2018 Volume: 25 Issue: 4

Cite

Vancouver Aydın Acar Ç, Yeşilot Ş. Kanserde MikroRNA’lar ve İlaç Yanıtı. Med J SDU. 2018;25(4):498-507.

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