Ratlarda 2.45 Ghz Elektromanyetik Alan Kaynaklı Kalp Dokusu Hasarı Üzerine C Vitamininin Koruyucu Etkileri”

Year 2020, Volume: 27 Issue: 1, 23 - 30, 01.03.2020

Halil Aşcı Mehtap Savran Nurhan Gümral Seçuk Çömlekçi Özlem Özmen

https://doi.org/10.17343/sdutfd.583987

Abstract

Gelişen teknoloji ile
birlikte günlük hayatın bir çok alanında elektromanyetik alanlar ( EMA) karşımıza
çıkmaktadır. İnsanlar, yerkürenin statik manyetik alanına ek olarak, yapay EMA
kaynaklarından farklı seviyelerde EMA’ya maruz kalırlar. Bir EMA dalga formu
olan radyofrekans (RF) dalga aralığında bulunan 2.45 GHz elektromanyetik radyasyonun
(EMR) endüstriyel, askeri ve bilimsel alanlarda kullanımı yaygındır. Bu çalışmada, EMA’nın
kalp dokusu üzerine etkisi ve C vitamininin (C vit) olası koruyucu rolünü
değerlendirmek için 18 dişi sıçan kontrol, EMA ve EMA + C vit olarak gruplara
ayrıldı. Sıçanların hareketini kısıtlayan bir düzenek yardımıyla EMA ve EMA + C
vit gruplarına 30 gün süreyle günde 60 dakika 2.24 mW/kg gücündeki 2.45
GHz EMA maruziyeti sağlandı. Tedavi grubuna ayrıca 30 gün boyunca C vit
uygulandı. Deney sonunda kalp dokularında yapılan analizlerde, EMA grubunun TAS değerlerinde kontrol grubuna göre
sayısal bir azalma gözlenirken, tedavi grubundaki TAS değerlerinde hem kontrol
hem de  EMA grubuna göre istatistiksel
olarak anlamlı bir artış gözlendi. EMA grubunda TOS ve OSI kontrol grubuna göre
istatistiksel olarak anlamlı yüksek iken, EMA+ C vit grubunda TOS değerindeki
azalma istatistiksel olarak anlamlı bulunmadı. Histopatolojik olarak, EMA
grubundaki belirgin hiperemi dışında major bir anomali gözlenmedi. EMA grubunda
immunhistokimyasal olarak tesbit edilen  kaspas-3
ve kaspas-8 ekspresyonları, tedavi grubunda izlenmedi.

Gelişen teknoloji ile birlikte, EMA
maruziyeti her geçen gün artmaktadır. Teknoloji kullanımının önlenmesinin
neredeyse imkansız olacağı düşünüldüğünde, EMA’ya bağlı gelişebilecek hasarın
en aza indirilmesinde C vitamini alternatif bir yöntem olarak görülebilir.

Keywords

Elektromanyetik alan, 2.45 Ghz, kalp, C vitamini

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